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Coexpression cluster:C1255

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Full id: C1255_cerebellum_postcentral_brain_paracentral_frontal_temporal_pons



Phase1 CAGE Peaks

Hg19::chr1:1950743..1950748,+p3@GABRD
Hg19::chr20:10273831..10273842,-p@chr20:10273831..10273842
-
Hg19::chr20:10286834..10286851,-p1@CU679782
Hg19::chr20:10287450..10287493,-p@chr20:10287450..10287493
-
Hg19::chr20:10287525..10287552,-p@chr20:10287525..10287552
-
Hg19::chr3:184103946..184103949,+p@chr3:184103946..184103949
+
Hg19::chr7:100244171..100244173,-p@chr7:100244171..100244173
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004890GABA-A receptor activity0.0185673269389271
GO:0016917GABA receptor activity0.0185673269389271
GO:0043168anion binding0.0185673269389271
GO:0031404chloride ion binding0.0185673269389271
GO:0005254chloride channel activity0.0185673269389271
GO:0005253anion channel activity0.0185673269389271
GO:0005230extracellular ligand-gated ion channel activity0.0185673269389271
GO:0030594neurotransmitter receptor activity0.0185673269389271
GO:0042165neurotransmitter binding0.0185673269389271
GO:0045211postsynaptic membrane0.0185673269389271
GO:0044456synapse part0.0185673269389271
GO:0015276ligand-gated ion channel activity0.0185673269389271
GO:0022834ligand-gated channel activity0.0185673269389271
GO:0008509anion transmembrane transporter activity0.0219718759987216
GO:0007268synaptic transmission0.0284548059185996
GO:0019226transmission of nerve impulse0.0303558813140233
GO:0030054cell junction0.0371413136077462
GO:0022836gated channel activity0.0412921752554391
GO:0007267cell-cell signaling0.044665939725298
GO:0005216ion channel activity0.044665939725298
GO:0022838substrate specific channel activity0.044665939725298
GO:0015267channel activity0.044665939725298
GO:0022803passive transmembrane transporter activity0.044665939725298



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.