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Coexpression cluster:C1274

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Full id: C1274_Preadipocyte_Olfactory_Adipocyte_amniotic_serous_spindle_mesodermal



Phase1 CAGE Peaks

Hg19::chr5:125759038..125759049,+p7@GRAMD3
Hg19::chr5:125759064..125759131,+p1@GRAMD3
Hg19::chr5:125759140..125759175,+p2@GRAMD3
Hg19::chr5:125759213..125759224,+p5@GRAMD3
Hg19::chr5:125759230..125759241,+p6@GRAMD3
Hg19::chr5:125759251..125759262,+p13@GRAMD3
Hg19::chr5:125759280..125759291,+p12@GRAMD3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
fibroblast1.79e-0776
Uber Anatomy
Ontology termp-valuen
adult organism2.60e-20114
neural tube3.37e-1956
neural rod3.37e-1956
future spinal cord3.37e-1956
neural keel3.37e-1956
regional part of nervous system2.58e-1753
regional part of brain2.58e-1753
ectoderm-derived structure8.75e-17171
ectoderm8.75e-17171
presumptive ectoderm8.75e-17171
ecto-epithelium1.01e-15104
brain6.92e-1568
future brain6.92e-1568
regional part of forebrain2.63e-1441
forebrain2.63e-1441
anterior neural tube2.63e-1441
future forebrain2.63e-1441
central nervous system1.41e-1381
structure with developmental contribution from neural crest4.98e-13132
neural plate1.88e-1282
presumptive neural plate1.88e-1282
nervous system1.47e-1189
telencephalon3.57e-1134
brain grey matter4.97e-1134
gray matter4.97e-1134
neurectoderm7.14e-1186
organ part2.08e-10218
regional part of telencephalon4.21e-1032
cerebral hemisphere4.25e-1032
organ component layer1.07e-0966
organ1.24e-09503
surface structure7.34e-0999
pre-chordal neural plate7.43e-0961
multi-cellular organism2.20e-08656
regional part of cerebral cortex5.91e-0822
organ system subdivision8.03e-08223
multi-tissue structure1.51e-07342
extraembryonic membrane1.60e-0714
membranous layer1.60e-0714
anatomical system1.86e-07624
anatomical group2.51e-07625
neocortex7.76e-0720


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186974.907389214879321.45832274679793e-050.000346937971190954
ELK4#2005716.2356816584683.35702334142222e-092.76938515604103e-07
GABPB1#255344.038676477818380.00980113494696150.0368513782167157
HDAC2#3066713.41562023662631.27676792256388e-089.45034479551018e-07
MYC#460975.22228187160949.4355989882785e-060.000251068668213202
NFKB1#479075.488063424193846.66568321176054e-060.000194947434599008
PBX3#5090721.91451268674414.11002992557057e-104.03428021989347e-08
POLR2A#543072.147453176558070.004747636447610280.022356210963162
RFX5#5993712.04791082719512.7106444306642e-081.86125571133556e-06
SMARCB1#6598615.64518495527781.8015574550748e-079.86126095652814e-06
SP1#666775.69838137814095.12280185510121e-060.000157312644206091
TAF1#687273.343046285745290.0002142336319622450.002468212497353
TBP#690873.706770687096390.0001039672097505110.00145221765669836
TCF12#6938710.63446490218646.49404108872792e-083.973234664708e-06
ZNF263#1012778.221841637010683.93423095812578e-071.90932689142982e-05



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.