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Coexpression cluster:C1312


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Full id: C1312_Eosinophils_Basophils_CD4_Natural_Mast_granulocyte_CD14CD16

Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell6.39e-38172
angioblastic mesenchymal cell6.39e-38172
hematopoietic oligopotent progenitor cell1.31e-35165
hematopoietic multipotent progenitor cell1.31e-35165
hematopoietic cell2.43e-35182
hematopoietic lineage restricted progenitor cell1.07e-31124
nongranular leukocyte8.50e-31119
CD14-positive, CD16-negative classical monocyte1.31e-2242
classical monocyte4.61e-2245
myeloid leukocyte7.75e-2076
myeloid cell2.44e-19112
common myeloid progenitor2.44e-19112
granulocyte monocyte progenitor cell9.32e-1771
myeloid lineage restricted progenitor cell1.52e-1570
common lymphoid progenitor1.82e-1553
lymphoid lineage restricted progenitor cell3.85e-1552
macrophage dendritic cell progenitor7.48e-1565
monopoietic cell4.55e-1463
mesenchymal cell1.09e-13358
connective tissue cell1.35e-13365
motile cell9.95e-12390
mature alpha-beta T cell6.21e-1018
alpha-beta T cell6.21e-1018
immature T cell6.21e-1018
mature T cell6.21e-1018
immature alpha-beta T cell6.21e-1018
T cell5.37e-0825
pro-T cell5.37e-0825
B cell2.63e-0714
lymphocyte of B lineage8.63e-0724
pro-B cell8.63e-0724
intermediate monocyte8.74e-079
CD14-positive, CD16-positive monocyte8.74e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.78e-20102
blood island1.78e-20102
bone marrow1.62e-1580
hemolymphoid system3.40e-15112
bone element9.35e-1586
connective tissue7.54e-13375
skeletal element3.95e-10101
skeletal system3.95e-10101
immune system5.50e-10115

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs

JASPAR motifs



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.