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Coexpression cluster:C1317


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Full id: C1317_Eosinophils_CD14CD16_CD14_Neutrophils_Basophils_Peripheral_CD4

Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell1.46e-39172
angioblastic mesenchymal cell1.46e-39172
hematopoietic lineage restricted progenitor cell1.25e-36124
hematopoietic oligopotent progenitor cell1.58e-36165
hematopoietic multipotent progenitor cell1.58e-36165
nongranular leukocyte7.80e-36119
hematopoietic cell9.84e-36182
myeloid leukocyte1.91e-3276
granulocyte monocyte progenitor cell5.40e-2971
CD14-positive, CD16-negative classical monocyte4.28e-2642
macrophage dendritic cell progenitor4.46e-2665
myeloid lineage restricted progenitor cell1.10e-2570
myeloid cell1.62e-25112
common myeloid progenitor1.62e-25112
classical monocyte4.83e-2545
monopoietic cell6.65e-2563
mesenchymal cell1.13e-15358
connective tissue cell7.83e-15365
motile cell1.97e-11390
lymphoid lineage restricted progenitor cell3.48e-1052
common lymphoid progenitor5.65e-1053
multi fate stem cell2.73e-09430
somatic stem cell3.57e-09436
mature alpha-beta T cell4.58e-0918
alpha-beta T cell4.58e-0918
immature T cell4.58e-0918
mature T cell4.58e-0918
immature alpha-beta T cell4.58e-0918
stem cell5.01e-09444
intermediate monocyte1.35e-079
CD14-positive, CD16-positive monocyte1.35e-079
native cell8.28e-07722
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.58e-36102
blood island2.58e-36102
hemolymphoid system4.53e-34112
bone marrow5.00e-3080
bone element3.27e-2886
skeletal element3.78e-19101
skeletal system3.78e-19101
immune system1.39e-18115
connective tissue4.40e-15375
lateral plate mesoderm1.04e-13216
musculoskeletal system2.39e-09167
haemolymphatic fluid2.77e-0715
organism substance2.77e-0715

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs

JASPAR motifs



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)


Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.