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Coexpression cluster:C134

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Full id: C134_skeletal_diaphragm_tongue_throat_Skeletal_skin_penis



Phase1 CAGE Peaks

Hg19::chr10:75391836..75391847,-p@chr10:75391836..75391847
-
Hg19::chr11:111783450..111783475,+p1@C11orf52
p1@HSPB2-C11orf52
p1@HSPB2
Hg19::chr11:111783485..111783497,+p2@HSPB2-C11orf52
Hg19::chr11:111783512..111783526,+p3@HSPB2-C11orf52
Hg19::chr11:1942566..1942578,+p14@TNNT3
Hg19::chr11:1942580..1942639,+p2@TNNT3
Hg19::chr11:1942642..1942649,+p13@TNNT3
Hg19::chr11:19835258..19835277,+p@chr11:19835258..19835277
+
Hg19::chr11:2170786..2170809,-p66@IGF2
Hg19::chr11:47206965..47206974,-p9@PACSIN3
Hg19::chr11:66633918..66633936,-p@chr11:66633918..66633936
-
Hg19::chr11:9450312..9450317,+p1@SNORA23
Hg19::chr12:3068942..3068953,+p13@TEAD4
Hg19::chr12:56548579..56548595,+p@chr12:56548579..56548595
+
Hg19::chr12:57112913..57112922,-p@chr12:57112913..57112922
-
Hg19::chr12:57114812..57114823,-p@chr12:57114812..57114823
-
Hg19::chr12:57115086..57115092,-p@chr12:57115086..57115092
-
Hg19::chr14:101356593..101356602,-p@chr14:101356593..101356602
-
Hg19::chr14:24600866..24600882,+p2@FITM1
Hg19::chr14:24601686..24601718,+p6@FITM1
Hg19::chr14:81916474..81916483,-p3@ENST00000555001
Hg19::chr14:81916503..81916517,-p1@ENST00000555001
Hg19::chr14:94423318..94423330,-p12@ASB2
Hg19::chr15:42651691..42651715,+p2@CAPN3
Hg19::chr15:77089901..77089941,-p@chr15:77089901..77089941
-
Hg19::chr16:30383613..30383616,+p@chr16:30383613..30383616
+
Hg19::chr16:30384030..30384072,+p@chr16:30384030..30384072
+
Hg19::chr16:30387474..30387490,+p@chr16:30387474..30387490
+
Hg19::chr16:30389152..30389161,+p23@ZNF48
Hg19::chr16:47430125..47430142,-p9@ITFG1
Hg19::chr16:67426950..67426958,-p@chr16:67426950..67426958
-
Hg19::chr16:67427030..67427043,-p@chr16:67427030..67427043
-
Hg19::chr16:89238149..89238187,+p1@CDH15
Hg19::chr16:89238188..89238199,+p3@CDH15
Hg19::chr16:89238212..89238224,+p2@CDH15
Hg19::chr17:10299730..10299770,-p@chr17:10299730..10299770
-
Hg19::chr17:10299918..10299924,-p@chr17:10299918..10299924
-
Hg19::chr17:10303744..10303773,+p@chr17:10303744..10303773
+
Hg19::chr17:10310119..10310123,-p@chr17:10310119..10310123
-
Hg19::chr17:10323360..10323378,+p@chr17:10323360..10323378
+
Hg19::chr17:10323363..10323366,-p3@MYH8
Hg19::chr17:10325261..10325267,-p1@MYH8
Hg19::chr17:10325303..10325311,-p2@MYH8
Hg19::chr17:10533450..10533457,+p@chr17:10533450..10533457
+
Hg19::chr17:10537375..10537387,-p@chr17:10537375..10537387
-
Hg19::chr17:10537430..10537439,-p@chr17:10537430..10537439
-
Hg19::chr17:10537442..10537452,-p@chr17:10537442..10537452
-
Hg19::chr17:10539045..10539068,+p@chr17:10539045..10539068
+
Hg19::chr17:10541616..10541630,-p@chr17:10541616..10541630
-
Hg19::chr17:10541701..10541714,+p@chr17:10541701..10541714
+
Hg19::chr17:10542429..10542477,+p@chr17:10542429..10542477
+
Hg19::chr17:10542690..10542702,-p2@MYH3
Hg19::chr17:10542721..10542730,-p6@MYH3
Hg19::chr17:10542947..10542952,+p@chr17:10542947..10542952
+
Hg19::chr17:10543000..10543023,+p@chr17:10543000..10543023
+
Hg19::chr17:10543362..10543373,-p8@MYH3
Hg19::chr17:10543535..10543570,-p3@MYH3
Hg19::chr17:10544511..10544520,-p@chr17:10544511..10544520
-
Hg19::chr17:10555831..10555857,-p@chr17:10555831..10555857
-
Hg19::chr17:10560619..10560631,-p1@MYH3
Hg19::chr17:10560665..10560669,-p5@MYH3
Hg19::chr17:25904469..25904479,+p12@KSR1
Hg19::chr17:40563207..40563209,-p@chr17:40563207..40563209
-
Hg19::chr17:45286297..45286312,+p5@MYL4
Hg19::chr17:65040577..65040582,+p4@CACNG1
Hg19::chr17:65040646..65040675,+p2@CACNG1
Hg19::chr17:65040678..65040733,+p1@CACNG1
Hg19::chr17:65040737..65040746,+p3@CACNG1
Hg19::chr17:65040748..65040753,+p5@CACNG1
Hg19::chr18:3193857..3193869,+p@chr18:3193857..3193869
+
Hg19::chr18:3220187..3220208,-p6@MYOM1
Hg19::chr18:55922928..55922935,+p@chr18:55922928..55922935
+
Hg19::chr19:14217762..14217764,-p@chr19:14217762..14217764
-
Hg19::chr19:14228521..14228536,-p2@PRKACA
Hg19::chr19:18554708..18554716,-p3@ENST00000541164
Hg19::chr19:18554726..18554736,-p2@ENST00000541164
Hg19::chr19:18554761..18554768,-p4@ENST00000541164
Hg19::chr19:33977922..33977934,-p@chr19:33977922..33977934
-
Hg19::chr19:34884793..34884811,+p@chr19:34884793..34884811
+
Hg19::chr19:34884817..34884868,+p@chr19:34884817..34884868
+
Hg19::chr19:46843663..46843674,+p8@HIF3A
Hg19::chr19:48283801..48283815,+p@chr19:48283801..48283815
+
Hg19::chr19:49222956..49222990,-p2@MAMSTR
Hg19::chr19:57417488..57417493,+p@chr19:57417488..57417493
+
Hg19::chr1:1846519..1846531,+p5@CALML6
Hg19::chr1:1846693..1846705,+p4@CALML6
Hg19::chr1:204420155..204420164,-p@chr1:204420155..204420164
-
Hg19::chr1:229567498..229567506,-p@chr1:229567498..229567506
-
Hg19::chr1:229568499..229568505,+p@chr1:229568499..229568505
+
Hg19::chr1:23743877..23743887,-p@chr1:23743877..23743887
-
Hg19::chr1:26316072..26316085,-p@chr1:26316072..26316085
-
Hg19::chr1:6615362..6615371,+p3@TAS1R1
Hg19::chr1:9129895..9129902,-p19@SLC2A5
Hg19::chr20:36152838..36152861,-p4@BLCAP
Hg19::chr20:36152878..36152889,-p9@BLCAP
Hg19::chr20:55091871..55091878,+p3@FAM209A
Hg19::chr20:57427765..57427783,+p51@GNAS
Hg19::chr22:36246064..36246069,-p@chr22:36246064..36246069
-
Hg19::chr22:36246136..36246155,-p@chr22:36246136..36246155
-
Hg19::chr22:36246158..36246175,-p@chr22:36246158..36246175
-
Hg19::chr2:127861232..127861245,-p@chr2:127861232..127861245
-
Hg19::chr2:179659754..179659767,+p@chr2:179659754..179659767
+
Hg19::chr2:220360850..220360855,+p@chr2:220360850..220360855
+
Hg19::chr2:233390904..233390920,+p2@CHRND
Hg19::chr2:233404417..233404428,+p3@CHRNG
Hg19::chr2:233404429..233404447,+p1@CHRNG
Hg19::chr2:24714729..24714761,+p1@NCOA1
Hg19::chr2:71681010..71681037,+p7@DYSF
Hg19::chr3:130236014..130236030,+p@chr3:130236014..130236030
+
Hg19::chr3:52869205..52869238,-p2@MUSTN1
Hg19::chr3:8775466..8775512,+p1@CAV3
Hg19::chr4:172396418..172396419,+p@chr4:172396418..172396419
+
Hg19::chr4:34898792..34898800,+p@chr4:34898792..34898800
+
Hg19::chr4:671754..671765,+p8@MYL5
Hg19::chr4:671780..671793,+p5@MYL5
Hg19::chr5:138730459..138730471,-p@chr5:138730459..138730471
-
Hg19::chr5:148758849..148758861,-p1@IL17B
Hg19::chr6:12007918..12007931,+p1@ENST00000437559
Hg19::chr6:12007963..12007974,+p3@ENST00000437559
Hg19::chr6:150621376..150621399,+p@chr6:150621376..150621399
+
Hg19::chr6:41020934..41020948,+p1@APOBEC2
Hg19::chr6:52001069..52001073,+p@chr6:52001069..52001073
+
Hg19::chr8:144523662..144523672,-p@chr8:144523662..144523672
-
Hg19::chr9:118024813..118024828,-p@chr9:118024813..118024828
-
Hg19::chr9:35683115..35683137,-p@chr9:35683115..35683137
-
Hg19::chr9:35684272..35684277,-p@chr9:35684272..35684277
-
Hg19::chr9:97356126..97356142,-p3@FBP2
Hg19::chrX:105445717..105445733,+p4@MUM1L1
Hg19::chrX:110513769..110513778,-p5@CAPN6
Hg19::chrX:119495934..119495950,+p1@ATP1B4
Hg19::chrX:125953692..125953697,+p3@CXorf64
Hg19::chrX:125953702..125953722,+p1@CXorf64
Hg19::chrX:130192273..130192296,+p2@ARHGAP36
Hg19::chrX:130192318..130192323,+p1@ARHGAP36
Hg19::chrX:63450480..63450511,-p2@ASB12
Hg19::chrX:99839925..99839938,+p1@TNMD


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
0.0006227450480061330.02627984102585883116Vascular smooth muscle contraction (KEGG):04270
0.0009259906422873520.03447953391575853133Tight junction (KEGG):04530
5.78723999284568e-050.0052333184506733352Taste transduction (KEGG):04742
0.001030126349370380.03622610995285833138Insulin signaling pathway (KEGG):04910
0.0004156107932587890.01879154515234383101GnRH signaling pathway (KEGG):04912
0.0004156107932587890.01879154515234383101Melanogenesis (KEGG):04916
4.83907462305162e-050.00510522372731946349Endocrine and other factor-regulated calcium reabsorption (KEGG):04961
8.18467518057476e-060.00103617987786076489Salivary secretion (KEGG):04970
3.91749345114846e-060.000619943338644243474Gastric acid secretion (KEGG):04971
0.0001468618346024030.0103292823670356371Bile secretion (KEGG):04976
0.0002962104988726520.0187501245786389390Dilated cardiomyopathy (KEGG):05414
0.0004156107932587890.01879154515234383101Integrin-mediated cell adhesion (Wikipathways):WP185
0.001438674903055320.04793059019126423155Myometrial Relaxation and Contraction Pathways (Wikipathways):WP289
2.63651271987377e-091.6689125516801e-06539Striated Muscle Contraction (Wikipathways):WP383
0.0003761868753793850.0187915451523438220Estrogen signaling pathway (Wikipathways):WP712
0.0007918330870943840.03132689650817163126Metabolism of carbohydrates (Reactome):REACT_474
7.4030763311946e-070.000234307365882309449Muscle contraction (Reactome):REACT_17044
3.34548286755118e-060.0006199433386442436288{ACTB,297} (Static Module):NA
6.84953780566463e-050.00541969678873214355{HTT,61} (Static Module):NA



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0003012muscle system process1.63605652331798e-11
GO:0006936muscle contraction1.63605652331798e-11
GO:0044449contractile fiber part3.97892675944685e-09
GO:0005859muscle myosin complex3.97892675944685e-09
GO:0043292contractile fiber3.97892675944685e-09
GO:0016460myosin II complex3.97892675944685e-09
GO:0006941striated muscle contraction3.71982413382398e-06
GO:0016459myosin complex4.5435415326943e-06
GO:0008307structural constituent of muscle4.88538578350844e-06
GO:0030017sarcomere7.61010017952327e-06
GO:0030016myofibril1.0373423694782e-05
GO:0015629actin cytoskeleton1.69922111733134e-05
GO:0032982myosin filament1.69922111733134e-05
GO:0005863striated muscle thick filament1.69922111733134e-05
GO:0007517muscle development2.57050151792898e-05
GO:0032501multicellular organismal process5.4432279681343e-05
GO:0003008system process5.78157480686019e-05
GO:0043234protein complex0.00234438634079895
GO:0042383sarcolemma0.00276217692501124
GO:0015464acetylcholine receptor activity0.00457728242701335
GO:0042166acetylcholine binding0.00479214619601587
GO:0004889nicotinic acetylcholine-activated cation-selective channel activity0.00500673024976491
GO:0044430cytoskeletal part0.00591913125683937
GO:0004198calcium-dependent cysteine-type endopeptidase activity0.00785538890721668
GO:0042391regulation of membrane potential0.00805604221009237
GO:0006937regulation of muscle contraction0.012280248506066
GO:0043176amine binding0.0142242377973511
GO:0048513organ development0.0142242377973511
GO:0015755fructose transport0.0142242377973511
GO:0031852mu-type opioid receptor binding0.0142242377973511
GO:0031628opioid receptor binding0.0142242377973511
GO:0005886plasma membrane0.0150953330950706
GO:0032991macromolecular complex0.0169128604294968
GO:0042132fructose-bisphosphatase activity0.0244850393232612
GO:0050917sensory perception of umami taste0.0244850393232612
GO:0043409negative regulation of MAPKKK cascade0.0244850393232612
GO:0005231excitatory extracellular ligand-gated ion channel activity0.0291384206340225
GO:0005856cytoskeleton0.0322324526947415
GO:0005353fructose transmembrane transporter activity0.0322324526947415
GO:0016556mRNA modification0.0322324526947415
GO:0051925regulation of calcium ion transport via voltage-gated calcium channel0.0322324526947415
GO:0008092cytoskeletal protein binding0.0338960784748465
GO:0005509calcium ion binding0.0342939600311016
GO:0051354negative regulation of oxidoreductase activity0.037471473076189
GO:0031579lipid raft organization and biogenesis0.037471473076189
GO:0045806negative regulation of endocytosis0.037471473076189
GO:0051001negative regulation of nitric-oxide synthase activity0.037471473076189
GO:0046716muscle maintenance0.0449050584866388
GO:0030315T-tubule0.0449050584866388
GO:0048731system development0.0471115443514867
GO:0051049regulation of transport0.0479835796689636
GO:0005861troponin complex0.0479835796689636
GO:0031594neuromuscular junction0.0479835796689636
GO:0006349genetic imprinting0.0479835796689636
GO:0004126cytidine deaminase activity0.0479835796689636



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
fat cell4.46e-0715
non-terminally differentiated cell8.58e-07180
Uber Anatomy
Ontology termp-valuen
adult organism2.17e-30115
neural tube1.06e-1257
neural rod1.06e-1257
future spinal cord1.06e-1257
neural keel1.06e-1257
organism subdivision6.59e-12365
regional part of brain8.44e-1259
central nervous system4.24e-1182
multi-cellular organism4.44e-11659
neural plate3.99e-1086
presumptive neural plate3.99e-1086
brain4.81e-1069
future brain4.81e-1069
regional part of nervous system1.01e-0994
nervous system1.01e-0994
neurectoderm1.82e-0990
multi-tissue structure2.02e-08347
anatomical system2.75e-08625
anatomical group3.77e-08626
anterior neural tube4.13e-0842
anterior region of body4.79e-08129
craniocervical region4.79e-08129
regional part of forebrain1.07e-0741
forebrain1.07e-0741
future forebrain1.07e-0741
organ1.32e-07511
ectoderm-derived structure1.42e-07169
head1.61e-07123
epithelium1.61e-07309
ectoderm2.95e-07173
presumptive ectoderm2.95e-07173
cell layer3.53e-07312
embryo3.54e-07612
tube9.47e-07194


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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