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Coexpression cluster:C1603

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Full id: C1603_Hepatocyte_colon_duodenum_small_gall_temporal_liver



Phase1 CAGE Peaks

Hg19::chr10:96500094..96500099,+p@chr10:96500094..96500099
+
Hg19::chr11:72492630..72492635,-p13@STARD10
Hg19::chr20:3052792..3052806,+p3@OXT
Hg19::chr6:25754961..25754980,+p1@SLC17A4
Hg19::chr6:25781321..25781354,+p@chr6:25781321..25781354
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0031895V1B vasopressin receptor binding0.00176610837712359
GO:0031855oxytocin receptor binding0.00176610837712359
GO:0050891body fluid osmoregulation0.00176610837712359
GO:0005185neurohypophyseal hormone activity0.00176610837712359
GO:0031894V1A vasopressin receptor binding0.00176610837712359
GO:0031893vasopressin receptor binding0.00176610837712359
GO:0005436sodium:phosphate symporter activity0.00313951715827406
GO:0018987osmoregulation0.00313951715827406
GO:0007567parturition0.00313951715827406
GO:0015114phosphate transmembrane transporter activity0.00494430280628434
GO:0005184neuropeptide hormone activity0.010591971141342
GO:0015296anion:cation symporter activity0.011473621593484
GO:0015103inorganic anion transmembrane transporter activity0.0192720292833527
GO:0001664G-protein-coupled receptor binding0.026200316927439
GO:0015294solute:cation symporter activity0.0268009883676938
GO:0050878regulation of body fluid levels0.0275458901971794
GO:0006814sodium ion transport0.0358555567995223
GO:0008509anion transmembrane transporter activity0.0402145638426299
GO:0005179hormone activity0.0402145638426299
GO:0015293symporter activity0.0425894721577773
GO:0048878chemical homeostasis0.0487516949656449
GO:0022414reproductive process0.0487516949656449



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
metabolising cell1.81e-0712
endopolyploid cell1.81e-0712
parenchymal cell1.81e-0712
polyploid cell1.81e-0712
hepatocyte1.81e-0712
endodermal cell6.85e-0759


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.