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Coexpression cluster:C1676

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Full id: C1676_neuroectodermal_synovial_breast_anaplastic_epitheloid_rhabdomyosarcoma_neuroepithelioma



Phase1 CAGE Peaks

Hg19::chr12:54366894..54366922,+p2@HOXC11
Hg19::chr12:54366949..54366973,+p3@HOXC11
Hg19::chr12:54366975..54367001,+p1@HOXC11
Hg19::chr12:54367012..54367025,+p5@HOXC11
Hg19::chr12:54367122..54367144,+p4@HOXC11


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
cell of skeletal muscle2.13e-089
smooth muscle cell of the umbilical artery3.05e-084
skeletal muscle myoblast2.76e-074
Uber Anatomy
Ontology termp-valuen
larynx1.04e-159
umbilical artery3.05e-084
upper respiratory tract8.37e-0819
umbilical blood vessel3.49e-079
articulation4.65e-078
skeletal joint4.65e-078
articular system4.65e-078
Disease
Ontology termp-valuen
cell type cancer6.28e-14143
carcinoma4.11e-09106
disease of cellular proliferation2.41e-07239
neuroectodermal tumor6.86e-0710
cancer6.89e-07235


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066455.360256373075030.0002259278299937090.002495576587701
GTF2F1#2962512.73966087675772.97806917252935e-060.000101015448622862
SUZ12#23512550.11578091106293.15480790456198e-092.61496018051229e-07
TAF1#687253.343046285745290.002394600090870310.0135212823794552
TBP#690853.706770687096390.001428755106721120.00917924179323618
USF1#739156.361499277207969.59569864925045e-050.00136777012587562
USF2#7392512.99219738506962.69963551658264e-069.417075274428e-05



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.