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Coexpression cluster:C2306

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Full id: C2306_CD4_CD8_cerebellum_Mast_Neural_thymus_Natural



Phase1 CAGE Peaks

Hg19::chr14:64108537..64108597,-p1@WDR89
Hg19::chr2:120517452..120517509,+p1@PTPN4
Hg19::chr2:120517517..120517541,+p2@PTPN4
Hg19::chr2:242041691..242041740,-p1@MTERFD2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004726non-membrane spanning protein tyrosine phosphatase activity0.00927234192864712



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
lymphocyte1.98e-2153
common lymphoid progenitor1.98e-2153
lymphoid lineage restricted progenitor cell5.56e-2152
mature alpha-beta T cell1.29e-1218
alpha-beta T cell1.29e-1218
immature T cell1.29e-1218
mature T cell1.29e-1218
immature alpha-beta T cell1.29e-1218
T cell4.64e-1225
pro-T cell4.64e-1225
lymphocyte of B lineage1.40e-0824
pro-B cell1.40e-0824
CD8-positive, alpha-beta T cell1.61e-0811
B cell1.91e-0714
Uber Anatomy
Ontology termp-valuen
adult organism2.00e-22115
central nervous system7.77e-1482
regional part of nervous system9.22e-1394
nervous system9.22e-1394
neural tube2.68e-1257
neural rod2.68e-1257
future spinal cord2.68e-1257
neural keel2.68e-1257
anterior neural tube6.43e-1242
regional part of forebrain6.61e-1241
forebrain6.61e-1241
future forebrain6.61e-1241
regional part of brain1.05e-1059
brain1.43e-1069
future brain1.43e-1069
telencephalon2.32e-0934
regional part of telencephalon4.58e-0933
gray matter4.81e-0934
brain grey matter4.81e-0934
cerebral hemisphere8.92e-0932
anterior region of body1.88e-07129
craniocervical region1.88e-07129
cerebral cortex1.89e-0725
pallium1.89e-0725
regional part of cerebral cortex3.36e-0722
neocortex8.78e-0720
blood9.17e-0715
haemolymphatic fluid9.17e-0715
organism substance9.17e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.