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Coexpression cluster:C2592

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Full id: C2592_testicular_teratocarcinoma_maxillary_chronic_transitionalcell_cervical_Saos2



Phase1 CAGE Peaks

Hg19::chr1:53308398..53308413,+p5@ZYG11A
Hg19::chr1:53308505..53308544,+p2@ZYG11A
Hg19::chr1:53308550..53308574,+p3@ZYG11A
Hg19::chr1:53345758..53345763,+p@chr1:53345758..53345763
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell1.09e-13253
germ line cell5.47e-077
germ cell5.47e-077
Uber Anatomy
Ontology termp-valuen
larynx3.23e-089
Disease
Ontology termp-valuen
cell type cancer1.03e-26143
carcinoma1.20e-25106
disease of cellular proliferation1.30e-25239
cancer1.64e-25235
organ system cancer2.64e-09137
respiratory system cancer9.40e-0716


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCLAF1#9774316.23948570759140.000380256706766480.00376682445205201
BRCA1#672315.13817298241780.0004682184421431190.004302707072502
CCNT2#90534.752151182721970.01386206996689490.0487257917768084
CEBPB#105135.978360719368610.007153832484726970.0297333297863897
CHD2#110637.758017125587640.003351522464536340.017301648691301
CTCFL#140690314.80985576923080.0004996291767563340.00440976688846909
E2F4#187439.501045236463330.001850751034728270.0109302526190899
ETS1#211337.296570691651750.00400857377511390.0192077186868747
GABPB1#255335.300762877136630.01012678824234270.0378672265392779
HMGN3#932436.133910792512940.006640696683324720.0282988298069916
IRF1#365935.727872815172930.008097114790333330.0320129683369027
MAX#414934.839416631755340.01315737137836840.0466316923233817
MXI1#460137.471178721569470.003741314738550960.0186368010101843
PAX5#507935.002174148383370.01196533174786410.0435053363882181
ZBTB33#10009323.74854377248590.0001229451908818380.00165595470602377
ZBTB7A#5134135.513931980906920.009038352821081090.0342484772614791



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.