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Coexpression cluster:C2665

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Full id: C2665_occipital_parietal_normal_temporal_duodenum_somatostatinoma_putamen



Phase1 CAGE Peaks

Hg19::chr2:166060382..166060411,-p4@SCN3A
Hg19::chr2:166060552..166060566,-p1@SCN3A
Hg19::chr2:166060571..166060582,-p2@SCN3A
Hg19::chr2:166060586..166060603,-p3@SCN3A


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
B cell1.84e-0814
Uber Anatomy
Ontology termp-valuen
adult organism4.22e-50115
neural tube4.31e-4157
neural rod4.31e-4157
future spinal cord4.31e-4157
neural keel4.31e-4157
central nervous system3.63e-4082
regional part of nervous system9.30e-3894
nervous system9.30e-3894
brain3.52e-3569
future brain3.52e-3569
regional part of brain1.39e-3459
anterior neural tube1.59e-3242
regional part of forebrain5.52e-3241
forebrain5.52e-3241
future forebrain5.52e-3241
gray matter8.93e-2834
brain grey matter8.93e-2834
neural plate1.34e-2786
presumptive neural plate1.34e-2786
telencephalon1.79e-2734
neurectoderm4.08e-2790
regional part of telencephalon1.05e-2633
cerebral hemisphere2.63e-2632
cerebral cortex1.59e-2025
pallium1.59e-2025
regional part of cerebral cortex3.28e-2022
pre-chordal neural plate1.89e-1961
neocortex1.76e-1820
anterior region of body7.38e-17129
craniocervical region7.38e-17129
ectoderm8.69e-17173
presumptive ectoderm8.69e-17173
ectoderm-derived structure9.72e-17169
head5.99e-16123
tube2.47e-11194
anatomical conduit8.36e-10241
posterior neural tube1.29e-0915
chordal neural plate1.29e-0915
anatomical cluster5.75e-09286
basal ganglion7.60e-099
nuclear complex of neuraxis7.60e-099
aggregate regional part of brain7.60e-099
collection of basal ganglia7.60e-099
cerebral subcortex7.60e-099
nucleus of brain1.13e-089
neural nucleus1.13e-089
temporal lobe5.28e-087
segmental subdivision of nervous system8.48e-0813
segmental subdivision of hindbrain1.94e-0712
hindbrain1.94e-0712
presumptive hindbrain1.94e-0712
telencephalic nucleus4.51e-077
brainstem5.09e-078
organ part5.40e-07219


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066445.360256373075030.001211145381643620.0081833999167677
RAD21#5885410.35503389545638.6948481184721e-050.00129614793412091
SMC3#9126415.04493284493281.95092670935632e-050.000438555390870565



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.