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Coexpression cluster:C3081

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Full id: C3081_Mast_CD19_pituitary_CD4_CD8_Peripheral_spinal



Phase1 CAGE Peaks

Hg19::chr11:108093755..108093832,+p1@ATM
Hg19::chr11:108094037..108094072,+p2@ATM
Hg19::chr15:62352570..62352658,-p1@VPS13C


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0007094mitotic cell cycle spindle assembly checkpoint0.0123605750498787
GO:0031577spindle checkpoint0.0123605750498787
GO:0010212response to ionizing radiation0.0123605750498787
GO:0035004phosphoinositide 3-kinase activity0.0123605750498787
GO:00163031-phosphatidylinositol-3-kinase activity0.0123605750498787
GO:0007131meiotic recombination0.0151058126866206
GO:0007093mitotic cell cycle checkpoint0.0158893604484329
GO:0007127meiosis I0.0160630702308775
GO:0001727lipid kinase activity0.0160630702308775
GO:0047485protein N-terminus binding0.0160630702308775
GO:0000075cell cycle checkpoint0.0182682777581781
GO:0004428inositol or phosphatidylinositol kinase activity0.0182682777581781
GO:0007088regulation of mitosis0.0182682777581781
GO:0051327M phase of meiotic cell cycle0.0182682777581781
GO:0007126meiosis0.0182682777581781
GO:0051321meiotic cell cycle0.0182682777581781
GO:0009314response to radiation0.0244477946042987
GO:0009628response to abiotic stimulus0.0376850227570919
GO:0006310DNA recombination0.042605422489093
GO:0045786negative regulation of progression through cell cycle0.0457285926147825
GO:0007067mitosis0.0457285926147825
GO:0000087M phase of mitotic cell cycle0.0457285926147825



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism4.32e-23115
neural tube1.34e-1257
neural rod1.34e-1257
future spinal cord1.34e-1257
neural keel1.34e-1257
anterior neural tube9.90e-1142
regional part of forebrain1.32e-1041
forebrain1.32e-1041
future forebrain1.32e-1041
regional part of brain1.89e-1059
brain6.42e-1069
future brain6.42e-1069
central nervous system2.87e-0982
regional part of nervous system2.95e-0894
nervous system2.95e-0894
gray matter5.06e-0834
brain grey matter5.06e-0834
telencephalon1.37e-0734
regional part of telencephalon1.71e-0733
neurectoderm2.06e-0790
neural plate6.39e-0786
presumptive neural plate6.39e-0786
cerebral hemisphere6.45e-0732
hematopoietic system8.74e-07102
blood island8.74e-07102


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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