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Coexpression cluster:C3513: Difference between revisions

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|full_id=C3513_Pericytes_placenta_embryonic_mesenchymal_Mesenchymal_neuroblastoma_Fibroblast
|full_id=C3513_Pericytes_placenta_embryonic_mesenchymal_Mesenchymal_neuroblastoma_Fibroblast
|id=C3513
|id=C3513
|ontology_enrichment_celltype=CL:0000133!1.19e-07!59
|ontology_enrichment_celltype=CL:0000349!7.15e-10!19;CL:0000133!6.72e-07!59
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000481!2.23e-13!347;UBERON:0005631!1.42e-09!14;UBERON:0000158!1.42e-09!14;UBERON:0001032!1.80e-09!24;UBERON:0004456!1.80e-09!24;UBERON:0000020!3.26e-09!23;UBERON:0002104!2.18e-08!21;UBERON:0000970!3.94e-08!20;UBERON:0003104!4.81e-08!238;UBERON:0009142!4.81e-08!238;UBERON:0000478!8.04e-08!24;UBERON:0001048!8.25e-08!168;UBERON:0002200!1.03e-07!11;UBERON:0006876!1.03e-07!11;UBERON:0000019!1.17e-07!19;UBERON:0000047!1.17e-07!19;UBERON:0004088!1.17e-07!19;UBERON:0003072!1.17e-07!19;UBERON:0003071!1.17e-07!19;UBERON:0004128!1.17e-07!19;UBERON:0001456!3.16e-07!21;UBERON:0000475!3.73e-07!365;UBERON:0004121!9.26e-07!169
|ontology_enrichment_uberon=UBERON:0005631!5.10e-10!14;UBERON:0000158!5.10e-10!14;UBERON:0000020!1.80e-09!24;UBERON:0001032!1.80e-09!24;UBERON:0004456!1.80e-09!24;UBERON:0000970!4.17e-08!21;UBERON:0002104!4.17e-08!21;UBERON:0006876!4.64e-08!11;UBERON:0000478!6.41e-08!24;UBERON:0007625!1.07e-07!11;UBERON:0000019!1.36e-07!20;UBERON:0000047!1.36e-07!20;UBERON:0010312!1.36e-07!20;UBERON:0004088!1.36e-07!20;UBERON:0010230!1.36e-07!20;UBERON:0003072!1.36e-07!20;UBERON:0004128!1.36e-07!20;UBERON:0003071!1.36e-07!20;UBERON:0001456!2.50e-07!22;UBERON:0000481!9.41e-07!342
|tf_chipseq_enrich=CTBP2#1488;3:62.7170003393281:4.049570681927e-06:0.000129456110330509!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0321444691395146!EP300#2033;3:6.7739417262232:0.00321688050010379:0.0167248000074841!GATA2#2624;3:12.744931733554:0.000482952770428379:0.00436513235748763
|tf_chipseq_enrich=CTBP2#1488;3:62.7170003393281:4.049570681927e-06:0.000129456110330509!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0321444691395146!EP300#2033;3:6.7739417262232:0.00321688050010379:0.0167248000074841!GATA2#2624;3:12.744931733554:0.000482952770428379:0.00436513235748763
|tfbs_overrepresentation=0.147255,0.0586687,0.00033887,0.0477154,0.199763,0.287811,0.0430074,0.414564,0.03272,0.0257057,0.139423,0.225367,0.188771,0.125978,0.148679,0.0619003,0.140982,0.0982016,0.0528514,0.108057,0.00130254,0.132577,0.081977,0.0948982,0.0415721,0.215492,0.209392,0.0907212,0.143747,0.0933697,0.204953,0.114046,0.0180314,0.208242,0.0665252,0.0844722,0.688181,0.0429682,0.120351,0.0667043,0.0964797,0.0246116,0.140039,0.184019,0.120917,0.0362416,0.0380166,0.18151,0.111283,0.121201,0.154071,0.0541794,0.0701653,0.0929951,0.198787,0.0384161,0.107455,0.212709,0.0783235,0.105572,0.0294301,0.149417,0.108602,0.0759481,0.054569,0.0504887,0.0709764,0.0600088,0.0860723,0.167053,0.378921,0.067678,0.089036,0.119383,0.00747605,0.0171177,0.0964936,0.0436945,0.0372495,0.00725252,0.0956287,0.226912,0.0425,0.114846,0.291327,0.251834,0.064341,0.209032,0.608896,0.062747,0.0857568,0.0495878,0.0953825,0.0473737,0.00375405,0.115028,0.58489,0.153631,0.0927458,0.0415725,0.0574857,0.276221,0.141874,0.0370665,0.219088,0.0409286,0.0669887,0.338096,0.144217,0.269326,0.182599,0.0339971,0.149552,0.0176855,0.101221,0.0337525,0.0203386,0.0566549,0.139021,0.0838393,0.16671,0.214708,0.140123,0.0857827,0.102368,0.176912,0.0906875,0.0147934,0.0843604,0.134932,0.0595773,0.0748346,0.0572164,0.0227861,0.125792,0.108101,0.0648644,0.0553359,0.0330399,0.00395526,0.022776,0.127606,0.203923,0.155998,0.596561,0.0693171,0.0988228,0.0842275,0.0389418,0.120833,0.200647,0.143677,0.180712,0.0265818,0.0427088,0.117549,0.0747594,0.228385,0.0516985,0.0337251,0.227719,0.0952829,0.116642,0.147788,0.273479,0.114283,0.0400322,0.127369,0.0403542,0.312091,0.179689,0.137725,0.00384591,0.0541353,0.0799324,0.090079,0.140334,0.181817,0.0169639,0.0356339,0.158844,0.122474,0.0274061,0.115574,0.0737247,0.118847,0.183031,0.0401756,0.0828697,0.173562,0.107145,0.187297,0.122935,0.228812,0.112671,0.0470731,0.0782523,0.0602859,0.0676496,0.109673,0.0893019,0.060398,0.0308319,0.0606036,0.136451,0.259411,0.27358,0.15185,0.206299,0.178359,0.0458667,0.104357,0.121154,0.1129,0.000610418,0.169057,0.164202,0.100942,0.062995,0.10299,0.14193,0.37245,0.15606,0.161026,0.0738599,0.126611,0.138852,0.085973,0.060453,0.059896,0.206862,0.384785,0.0418404,0.0765029,0.0959204,0.0931946,0.0472272,0.263087,0.163502,0.214803,0.182472,0.348993,0.0983991,0.0830921,0.116283,0.136838,0.0815104,0.111647,0.00136269,0.117027,0.159052,0.185164,0.185743,0.0980288,0.0980899,0.159674,0.107242,0.00161471,0.0695832,0.582402,0.0619218,0.1751,0.163376,0.0085789,0.0345133,0.0810678,0.0811639,0.0920653,0.118078,0.0755168,0.278352,0.063292,0.254773,0.446759,0.0865903,0.0380459,0.130174,0.584917,0.000318664,0.0691572,0.00381937,0.051522,0.0319444,0.807281,0.0083957,0.261644,0.0376513,0.446302,0.0806291,0.309233,0.49143,0.00800846,0.395854,0.061507,0.53472,0.615744,0.271958,0.292154,0.405773,0.0921263,0.217139,0.230901,0.187251,0.362792,0.181715,0.423979,0.109988,0.330894,0.218329,0.427027,0.0014339,0.463191,0.647576,0.173877,0.520763,0.0117562,0.415647,0.000615629,0.253571,0.276829,0.000521481,0.481778,0.0565541,0.223503,0.503224,0.603208,0.283727,0.314747,0.0567394,0.291709,0.448095,0.0115542,0.416816,0.0478086,0.137839,0.439556,0.0807167,0.57762,0.00280546,0.00117064,0.126021,0.248484,0.747852,0.00438172,0.236471,0.185661,0.346319,0.0427964,0.270984,0.258117,0.503058,0.513852,0.522083,0.248634,0.281576,0.472384,0.163244,0.0670502,0.0730934,0.184794,0.0138549,0.000729888,0.581837,0.412837,0.305671,0.546839,0.191921,0.120021,0.0258593,0.00665903,0.00743804,0.0451077,0.0747529,0.229003,0.650179,0.589326,0.00568155,0.294698,0.34331,0.477304,0.289204,0.327108,0.000194033,0.00452305,0.0263998,0.428671,0.228096,0.00847033,0.19763,0.15631,0.567452,0.421464,0.48267,0.00239933,0.516462,0.858756,0.335105,0.144809,0.145539,0.385517,0.376191,0.447325,0.459928,0.252232,0.152681,0.0465712,0.137098,0.259235,0.134788,0.0985856,0.18767,0.293698,0.00488039,0.343734,0.00055939,0.00617767,0.601433,0.503082,0.522888,0.00488238,0.262537,0.359455,0.226257,0.0965765,0.41707,0.0760312,0.464871,0.166672,0.206222,0.171685,0.284166,0.113671,0.040018,0.339277,0.552319,0.281425,0.141758,0.124432,0.520495,0.0134764,0.238587,0.372281,0.232251,0.0192138,0.0891382,0.0595618,0.0397695,0.257493,0.347298,0.539392,0.0699395,0.475069,0.404569,0.6408,0.0793778,0.316179,0.0697683,0.0556835,0.192544,8.39939e-05,0.0575676,0.144322,0.223391,0.203656,0.00307017,0.441735,0.191777,0.111931,0.28934,0.0435386,0.0515253,0.126478,0.134852,0.10689,0.00427764,0.0627924,0.381386,0.0179103,0.303939,0.279795,0.390395,0.0464827,0.169603,0.114583,0.104559,0.0899537,0.0866966,0.15983,0.107111,0.0438639,0.00389058,0.123593,0.129156,0.210369,0.193675,0.346372,0.0499762,0.0828956,0.0666953,0.182185,0.111277,0.219383,0.332809,0.19559,0.132201,0.188694,0.0481795,0.199971,0.406014,0.127758,0.175785,0.0181729,0.169234,0.0876426,0.0952322,0.0112557,0.222432,0.107043,0.275244,0.00481323,0.173708,0.141119,0.0241568,0.0300692,0.131551,0.0445237,0.052362,0.208866,0.153187,0.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}}
}}

Revision as of 15:10, 19 October 2012


Full id: C3513_Pericytes_placenta_embryonic_mesenchymal_Mesenchymal_neuroblastoma_Fibroblast



Phase1 CAGE Peaks

Hg19::chr15:74494779..74494799,-p2@STRA6
Hg19::chr15:74494801..74494829,-p3@STRA6
Hg19::chr15:74494832..74494841,-p7@STRA6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
extraembryonic cell7.15e-1019
neurectodermal cell6.72e-0759
Uber Anatomy
Ontology termp-valuen
extraembryonic membrane5.10e-1014
membranous layer5.10e-1014
sense organ1.80e-0924
sensory system1.80e-0924
entire sense organ system1.80e-0924
eye4.17e-0821
visual system4.17e-0821
vasculature of organ4.64e-0811
extraembryonic structure6.41e-0824
pigment epithelium of eye1.07e-0711
camera-type eye1.36e-0720
simple eye1.36e-0720
immature eye1.36e-0720
ocular region1.36e-0720
eyeball of camera-type eye1.36e-0720
optic cup1.36e-0720
optic vesicle1.36e-0720
eye primordium1.36e-0720
face2.50e-0722
multi-tissue structure9.41e-07342


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488362.71700033932814.049570681927e-060.000129456110330509
E2F6#187635.017155731697390.00791769806886330.0321444691395146
EP300#203336.77394172622320.003216880500103790.0167248000074841
GATA2#2624312.7449317335540.0004829527704283790.00436513235748763



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.