Coexpression cluster:C366

Full id: C366_heart_vagina_adipose_diaphragm_left_aorta_breast

Phase1 CAGE Peaks

Hg19::chr10:15647768..15647794,-	p@chr10:15647768..15647794 -
Hg19::chr10:92678409..92678410,-	p@chr10:92678409..92678410 -
Hg19::chr11:123340107..123340127,+	p@chr11:123340107..123340127 +
Hg19::chr12:2386467..2386484,+	p@chr12:2386467..2386484 +
Hg19::chr12:2468720..2468724,+	p@chr12:2468720..2468724 +
Hg19::chr13:31729140..31729163,-	p@chr13:31729140..31729163 -
Hg19::chr14:102550059..102550072,-	p@chr14:102550059..102550072 -
Hg19::chr14:102551390..102551436,-	p10@HSP90AA1
Hg19::chr14:102551456..102551467,-	p27@HSP90AA1
Hg19::chr14:92349687..92349698,-	p@chr14:92349687..92349698 -
Hg19::chr15:35082449..35082469,-	p@chr15:35082449..35082469 -
Hg19::chr15:86272097..86272099,+	p@chr15:86272097..86272099 +
Hg19::chr16:10783399..10783401,+	p@chr16:10783399..10783401 +
Hg19::chr17:77026478..77026512,+	p@chr17:77026478..77026512 +
Hg19::chr19:14628234..14628252,-	p@chr19:14628234..14628252 -
Hg19::chr19:2716727..2716731,-	p10@DIRAS1
Hg19::chr1:159174559..159174571,+	p3@DARC
Hg19::chr22:47045714..47045722,+	p@chr22:47045714..47045722 +
Hg19::chr3:46505091..46505110,-	p5@LTF
Hg19::chr3:64517143..64517146,-	p@chr3:64517143..64517146 -
Hg19::chr3:64673668..64673684,-	p1@ADAMTS9
Hg19::chr4:95332178..95332184,+	p@chr4:95332178..95332184 +
Hg19::chr5:99385820..99385831,-	p@chr5:99385820..99385831 -
Hg19::chr5:99390735..99390743,-	p@chr5:99390735..99390743 -
Hg19::chr6:31785440..31785544,+	p@chr6:31785440..31785544 +
Hg19::chr6:31785565..31785576,+	p@chr6:31785565..31785576 +
Hg19::chr6:31797870..31797898,+	p6@HSPA1B
Hg19::chr7:105926145..105926185,-	p7@NAMPT
Hg19::chr7:105926216..105926230,-	p10@NAMPT
Hg19::chr9:124095011..124095025,+	p@chr9:124095011..124095025 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042026	protein refolding	0.0216354645001766
GO:0030911	TPR domain binding	0.0260593848696238
GO:0030235	nitric-oxide synthase regulator activity	0.0260593848696238
GO:0009607	response to biotic stimulus	0.0260593848696238
GO:0045429	positive regulation of nitric oxide biosynthetic process	0.0346024795986266
GO:0045428	regulation of nitric oxide biosynthetic process	0.0360400055870461
GO:0006516	glycoprotein catabolic process	0.0475392087874602
GO:0006952	defense response	0.0475392087874602
GO:0046209	nitric oxide metabolic process	0.0475392087874602
GO:0006809	nitric oxide biosynthetic process	0.0475392087874602

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	2.14e-54	114
neural tube	4.06e-18	56
neural rod	4.06e-18	56
future spinal cord	4.06e-18	56
neural keel	4.06e-18	56
neurectoderm	6.81e-18	86
neural plate	2.23e-17	82
presumptive neural plate	2.23e-17	82
brainstem	3.39e-15	6
regional part of nervous system	3.48e-15	53
regional part of brain	3.48e-15	53
structure with developmental contribution from neural crest	4.10e-13	132
valve	9.86e-13	3
cardiac mesenchyme	9.86e-13	3
cardial valve	9.86e-13	3
tunica intima	9.86e-13	3
heart layer	9.86e-13	3
endocardium	9.86e-13	3
endocardial cushion	9.86e-13	3
presumptive endocardium	9.86e-13	3
ecto-epithelium	1.53e-12	104
male genital duct	4.59e-12	3
internal male genitalia	4.59e-12	3
medulla oblongata	2.35e-11	3
myelencephalon	2.35e-11	3
future myelencephalon	2.35e-11	3
posterior neural tube	5.33e-11	15
chordal neural plate	5.33e-11	15
central nervous system	5.39e-11	81
brain	8.65e-11	68
future brain	8.65e-11	68
brain grey matter	2.50e-10	34
gray matter	2.50e-10	34
anatomical cluster	6.79e-10	373
regional part of forebrain	9.48e-10	41
forebrain	9.48e-10	41
anterior neural tube	9.48e-10	41
future forebrain	9.48e-10	41
neural nucleus	9.87e-10	9
nucleus of brain	9.87e-10	9
nervous system	1.74e-09	89
anatomical conduit	3.33e-09	240
duct of male reproductive system	3.79e-09	4
atrioventricular valve	4.31e-09	2
organ system subdivision	4.63e-09	223
open tracheal system trachea	8.23e-09	2
compound organ	8.50e-09	68
tube	1.05e-08	192
locus ceruleus	1.15e-08	2
brainstem nucleus	1.15e-08	2
hindbrain nucleus	1.15e-08	2
telencephalon	2.69e-08	34
multi-tissue structure	4.94e-08	342
segmental subdivision of hindbrain	1.99e-07	12
hindbrain	1.99e-07	12
presumptive hindbrain	1.99e-07	12
regional part of telencephalon	2.92e-07	32
pre-chordal neural plate	6.84e-07	61
segmental subdivision of nervous system	7.89e-07	13
ectoderm-derived structure	7.93e-07	171
ectoderm	7.93e-07	171
presumptive ectoderm	7.93e-07	171

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.