Coexpression cluster:C3664

Full id: C3664_immature_Eosinophils_CD19_CD34_CD8_Basophils_Natural

Phase1 CAGE Peaks

Hg19::chr17:63052607..63052621,-	p5@GNA13
Hg19::chr17:63052647..63052656,-	p8@GNA13
Hg19::chr19:1067595..1067602,+	p13@HMHA1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001569	patterning of blood vessels	0.0286160956533637
GO:0030168	platelet activation	0.0286160956533637
GO:0009880	embryonic pattern specification	0.0286160956533637
GO:0048754	branching morphogenesis of a tube	0.0286160956533637
GO:0001763	morphogenesis of a branching structure	0.0286160956533637
GO:0022603	regulation of anatomical structure morphogenesis	0.0286160956533637
GO:0008360	regulation of cell shape	0.0286160956533637
GO:0022604	regulation of cell morphogenesis	0.0286160956533637
GO:0001701	in utero embryonic development	0.0286160956533637
GO:0007242	intracellular signaling cascade	0.0286160956533637
GO:0030334	regulation of cell migration	0.0286160956533637
GO:0051270	regulation of cell motility	0.0286160956533637
GO:0040012	regulation of locomotion	0.0286160956533637
GO:0040011	locomotion	0.0286160956533637
GO:0048770	pigment granule	0.0286160956533637
GO:0042470	melanosome	0.0286160956533637
GO:0035239	tube morphogenesis	0.0286160956533637
GO:0009792	embryonic development ending in birth or egg hatching	0.0286160956533637
GO:0043009	chordate embryonic development	0.0286160956533637
GO:0007596	blood coagulation	0.0286160956533637
GO:0050817	coagulation	0.0286160956533637
GO:0007599	hemostasis	0.0286160956533637
GO:0035295	tube development	0.0290793577129261
GO:0007389	pattern specification process	0.0290793577129261
GO:0050878	regulation of body fluid levels	0.0290793577129261
GO:0001525	angiogenesis	0.0290793577129261
GO:0042060	wound healing	0.0290793577129261
GO:0048514	blood vessel morphogenesis	0.0314582166780712
GO:0048646	anatomical structure formation	0.0316103854707933
GO:0001568	blood vessel development	0.0320774222547536
GO:0001944	vasculature development	0.0320774222547536
GO:0005057	receptor signaling protein activity	0.0331288121646884
GO:0007266	Rho protein signal transduction	0.0341158333290568
GO:0001775	cell activation	0.0367997456970307
GO:0016477	cell migration	0.0381693333830571
GO:0009790	embryonic development	0.0381693333830571
GO:0050793	regulation of developmental process	0.0381693333830571
GO:0003924	GTPase activity	0.0431248353376819

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.