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Coexpression cluster:C3668

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Full id: C3668_Mallassezderived_Prostate_Urothelial_Bronchial_Gingival_Small_Esophageal



Phase1 CAGE Peaks

Hg19::chr17:6544328..6544342,+p2@TXNDC17
Hg19::chr17:6544356..6544363,+p3@TXNDC17
Hg19::chr17:6544372..6544386,+p1@TXNDC17


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
mesenchyme9.36e-15238
entire embryonic mesenchyme9.36e-15238
trunk mesenchyme7.00e-14143
trunk1.53e-13216
multilaminar epithelium1.10e-1282
somite2.08e-1183
paraxial mesoderm2.08e-1183
presomitic mesoderm2.08e-1183
presumptive segmental plate2.08e-1183
trunk paraxial mesoderm2.08e-1183
presumptive paraxial mesoderm2.08e-1183
epithelial tube1.75e-10118
dermomyotome2.04e-1070
unilaminar epithelium3.02e-10138
skeletal muscle tissue1.21e-0861
striated muscle tissue1.21e-0861
myotome1.21e-0861
muscle tissue5.80e-0863
musculature5.80e-0863
musculature of body5.80e-0863
vasculature1.33e-0779
vascular system1.33e-0779
multi-tissue structure1.44e-07347
subdivision of trunk4.50e-07113
artery5.06e-0742
arterial blood vessel5.06e-0742
arterial system5.06e-0742


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0189863843763412
E2F1#186934.907389214879320.008460985347239390.0324981372027632
E2F6#187635.017155731697390.00791769806886330.0321782422217299
EGR1#195834.988179094810140.008056488137383440.03203180921959
ELF1#199734.258097958807540.01295179875054610.0461757666999482
ELK4#2005316.2356816584680.0002336043955745990.00255604080350084
ETS1#211339.728760922202340.001085840092584840.00761612178841288
FOSL2#2355316.93020060456170.0002060162053171620.00242818265061721
GABPB1#255337.067683836182170.002832212825417420.0153970889216475
IRF1#365937.63716375356390.002244692747297240.0127951897082729
MAX#414936.452555509007120.003721913834265510.0186352633844794
MXI1#460139.96157162875930.001011470541259020.00719695952163449
MYC#460935.22228187160940.007020843755740150.0294206115237229
NFKB1#479035.488063424193840.006049381815655430.0269386171255378
NR3C1#2908314.9730233311730.0002978331194675480.00308646489026308
PAX5#507936.669565531177830.003370290999677260.0172789662616118
POU2F2#545239.106124057742520.001324165192682130.00881642793309505
REST#597839.650028716128020.001112636247114590.00766862119794104
SIN3A#2594235.408884726815140.006318961977991520.0276394048674229
SIX5#147912317.0867153554590.0002004060546325010.00239530875941449
SP1#666735.69838137814090.005403962701712170.0246251782627565
SPI1#668838.204323508522730.001810593189410520.0109001926509595
SREBF1#6720347.00584944048839.62099323994382e-060.000254574844942106
SRF#6722313.79717826216780.0003806615025800190.00374737549891174
STAT1#6772320.70658749719920.0001125992441046670.00154753947296319
TAF7#6879311.43306940492390.0006690181981945830.00542312881102484
TCF12#6938310.63446490218640.0008313523990202070.006288976763818
TCF7L2#6934310.77017656313730.0008003181298398380.00613058714701063
USF1#739136.361499277207960.00388404057290560.0190095746470635
YY1#752834.911170749853860.008441455341808260.032898617599937
ZBTB7A#5134137.35190930787590.002516255860282270.0140030503432631
ZNF263#1012738.221841637010680.001799043925565870.0109321201223119



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.