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Coexpression cluster:C3857: Difference between revisions

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|tf_chipseq_enrich=CCNT2#905;3:6.33620157696263:0.00393075003576489:0.0190074823124942!CTBP2#1488;3:62.7170003393281:4.049570681927e-06:0.000129773891515733!CTCF#10664;3:5.36025637307503:0.006492509252767:0.0279490199847382!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0322284070704659!EBF1#1879;3:8.906466846569:0.0014152328356098:0.00915374386067086!EP300#2033;3:6.7739417262232:0.00321688050010379:0.0167473098325278!FOXA1#3169;3:11.0814197493855:0.00073475527569867:0.00581341713929495!GATA3#2625;3:27.236516357206:4.94721007899563e-05:0.000851205392817503!HMGN3#9324;3:8.17854772335059:0.00182776694216421:0.010871975832822!MAX#4149;3:6.45255550900712:0.00372191383426551:0.0186549387597473!NRF1#4899;3:12.2102794477109:0.000549217240102001:0.00471243011329386!PAX5#5079;3:6.66956553117783:0.00337029099967726:0.0172942476153537!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.00664169500036086!RFX5#5993;3:12.0479108271951:0.000571724605031258:0.00484583233443106!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0276846241303573!STAT3#6774;3:10.5194649971542:0.000858918453041531:0.0064267505600519!SUZ12#23512;3:50.1157809110629:7.93834897779404e-06:0.000222331249367614!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0109435813700375
|tf_chipseq_enrich=CCNT2#905;3:6.33620157696263:0.00393075003576489:0.0190074823124942!CTBP2#1488;3:62.7170003393281:4.049570681927e-06:0.000129773891515733!CTCF#10664;3:5.36025637307503:0.006492509252767:0.0279490199847382!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0322284070704659!EBF1#1879;3:8.906466846569:0.0014152328356098:0.00915374386067086!EP300#2033;3:6.7739417262232:0.00321688050010379:0.0167473098325278!FOXA1#3169;3:11.0814197493855:0.00073475527569867:0.00581341713929495!GATA3#2625;3:27.236516357206:4.94721007899563e-05:0.000851205392817503!HMGN3#9324;3:8.17854772335059:0.00182776694216421:0.010871975832822!MAX#4149;3:6.45255550900712:0.00372191383426551:0.0186549387597473!NRF1#4899;3:12.2102794477109:0.000549217240102001:0.00471243011329386!PAX5#5079;3:6.66956553117783:0.00337029099967726:0.0172942476153537!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.00664169500036086!RFX5#5993;3:12.0479108271951:0.000571724605031258:0.00484583233443106!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0276846241303573!STAT3#6774;3:10.5194649971542:0.000858918453041531:0.0064267505600519!SUZ12#23512;3:50.1157809110629:7.93834897779404e-06:0.000222331249367614!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0109435813700375
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}}
}}

Revision as of 16:23, 26 November 2012


Full id: C3857_spinal_cerebellum_salivary_hippocampus_medulla_skeletal_amygdala



Phase1 CAGE Peaks

Hg19::chr1:145039782..145039796,-p10@PDE4DIP
Hg19::chr1:145039835..145039853,-p6@PDE4DIP
Hg19::chr1:145039864..145039875,-p9@PDE4DIP


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism3.66e-27114
neural tube1.02e-2456
neural rod1.02e-2456
future spinal cord1.02e-2456
neural keel1.02e-2456
regional part of nervous system8.19e-2353
regional part of brain8.19e-2353
brain1.08e-1968
future brain1.08e-1968
central nervous system3.52e-1981
structure with developmental contribution from neural crest5.24e-19132
regional part of forebrain1.48e-1841
forebrain1.48e-1841
anterior neural tube1.48e-1841
future forebrain1.48e-1841
neural plate1.53e-1882
presumptive neural plate1.53e-1882
nervous system2.52e-1789
neurectoderm7.13e-1786
ecto-epithelium1.48e-16104
multi-cellular organism1.58e-16656
telencephalon3.12e-1634
brain grey matter3.23e-1634
gray matter3.23e-1634
organ4.72e-16503
anatomical system2.92e-15624
anatomical group3.01e-15625
regional part of telencephalon5.51e-1532
cerebral hemisphere6.05e-1532
ectoderm-derived structure1.90e-14171
ectoderm1.90e-14171
presumptive ectoderm1.90e-14171
musculoskeletal system2.25e-14167
embryonic structure4.54e-14564
germ layer6.15e-14560
germ layer / neural crest6.15e-14560
embryonic tissue6.15e-14560
presumptive structure6.15e-14560
germ layer / neural crest derived structure6.15e-14560
epiblast (generic)6.15e-14560
regional part of cerebral cortex1.47e-1222
neocortex2.04e-1120
cerebral cortex2.93e-1125
pallium2.93e-1125
pre-chordal neural plate4.15e-1161
developing anatomical structure4.92e-11581
embryo8.38e-10592
skeletal system1.17e-09100
tissue5.80e-09773
skeletal element5.90e-0990
bone element2.61e-0882
bone marrow1.06e-0776
posterior neural tube2.33e-0715
chordal neural plate2.33e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190074823124942
CTBP2#1488362.71700033932814.049570681927e-060.000129773891515733
CTCF#1066435.360256373075030.0064925092527670.0279490199847382
E2F6#187635.017155731697390.00791769806886330.0322284070704659
EBF1#187938.9064668465690.00141523283560980.00915374386067086
EP300#203336.77394172622320.003216880500103790.0167473098325278
FOXA1#3169311.08141974938550.000734755275698670.00581341713929495
GATA3#2625327.2365163572064.94721007899563e-050.000851205392817503
HMGN3#932438.178547723350590.001827766942164210.010871975832822
MAX#414936.452555509007120.003721913834265510.0186549387597473
NRF1#4899312.21027944771090.0005492172401020010.00471243011329386
PAX5#507936.669565531177830.003370290999677260.0172942476153537
RAD21#5885310.35503389545630.0009004912073565420.00664169500036086
RFX5#5993312.04791082719510.0005717246050312580.00484583233443106
SIN3A#2594235.408884726815140.006318961977991520.0276846241303573
STAT3#6774310.51946499715420.0008589184530415310.0064267505600519
SUZ12#23512350.11578091106297.93834897779404e-060.000222331249367614
ZNF263#1012738.221841637010680.001799043925565870.0109435813700375



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.