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Coexpression cluster:C3890

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Full id: C3890_spinal_amygdala_locus_medulla_hippocampus_optic_globus



Phase1 CAGE Peaks

Hg19::chr1:160175117..160175136,+p2@PEA15
Hg19::chr1:160175166..160175195,+p1@PEA15
Hg19::chr1:160175201..160175212,+p4@PEA15


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube2.93e-2956
neural rod2.93e-2956
future spinal cord2.93e-2956
neural keel2.93e-2956
structure with developmental contribution from neural crest1.18e-27132
regional part of nervous system3.11e-2753
regional part of brain3.11e-2753
neural plate3.70e-2782
presumptive neural plate3.70e-2782
central nervous system5.54e-2781
brain4.34e-2568
future brain4.34e-2568
ecto-epithelium1.07e-24104
neurectoderm8.94e-2486
nervous system1.35e-2389
tube3.20e-23192
cell layer4.85e-22309
epithelium1.61e-21306
anatomical group2.32e-21625
anatomical system3.19e-21624
anatomical conduit7.96e-21240
multi-cellular organism1.08e-20656
regional part of forebrain1.47e-2041
forebrain1.47e-2041
anterior neural tube1.47e-2041
future forebrain1.47e-2041
brain grey matter8.81e-2034
gray matter8.81e-2034
telencephalon1.42e-1934
ectoderm-derived structure5.57e-19171
ectoderm5.57e-19171
presumptive ectoderm5.57e-19171
regional part of telencephalon1.97e-1832
pre-chordal neural plate2.21e-1861
cerebral hemisphere2.38e-1832
embryonic structure1.25e-15564
germ layer3.97e-15560
germ layer / neural crest3.97e-15560
embryonic tissue3.97e-15560
presumptive structure3.97e-15560
germ layer / neural crest derived structure3.97e-15560
epiblast (generic)3.97e-15560
anatomical cluster5.10e-15373
developing anatomical structure5.63e-15581
embryo3.50e-14592
cerebral cortex5.35e-1425
pallium5.35e-1425
regional part of cerebral cortex5.95e-1322
neocortex1.23e-1120
splanchnic layer of lateral plate mesoderm2.14e-1183
organ6.15e-11503
vasculature8.45e-1178
vascular system8.45e-1178
multi-tissue structure1.13e-10342
vessel2.31e-1068
artery3.07e-1042
arterial blood vessel3.07e-1042
arterial system3.07e-1042
epithelial tube open at both ends4.15e-1059
blood vessel4.15e-1059
blood vasculature4.15e-1059
vascular cord4.15e-1059
organ part4.46e-10218
posterior neural tube7.25e-1015
chordal neural plate7.25e-1015
segmental subdivision of nervous system1.49e-0813
adult organism2.43e-08114
systemic artery5.26e-0833
systemic arterial system5.26e-0833
segmental subdivision of hindbrain6.20e-0812
hindbrain6.20e-0812
presumptive hindbrain6.20e-0812
epithelial vesicle1.82e-0778
basal ganglion2.40e-079
nuclear complex of neuraxis2.40e-079
aggregate regional part of brain2.40e-079
collection of basal ganglia2.40e-079
cerebral subcortex2.40e-079
neural nucleus2.50e-079
nucleus of brain2.50e-079
multilaminar epithelium3.25e-0783
tissue3.45e-07773
dense mesenchyme tissue4.55e-0773
epithelial tube6.51e-07117
paraxial mesoderm7.11e-0772
presumptive paraxial mesoderm7.11e-0772


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186934.907389214879320.008460985347239390.0325508103540109
ELF1#199734.258097958807540.01295179875054610.0462515526809917
GABPB1#255337.067683836182170.002832212825417420.0154195629085008
JUND#372736.994663941871030.002921845042734990.0156843428463302
SIN3A#2594235.408884726815140.006318961977991520.0276927560748377
ZBTB7A#5134137.35190930787590.002516255860282270.0140284655843709



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.