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Coexpression cluster:C3970

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Full id: C3970_Smooth_Fibroblast_basal_Mesothelial_mesenchymal_leiomyoma_Aortic



Phase1 CAGE Peaks

Hg19::chr1:32264166..32264245,-p2@SPOCD1
Hg19::chr1:32264250..32264354,-p1@SPOCD1
Hg19::chr1:32264356..32264380,-p3@SPOCD1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
epithelial vesicle3.06e-2478
vasculature1.31e-2378
vascular system1.31e-2378
multilaminar epithelium5.90e-2383
somite7.78e-2371
presomitic mesoderm7.78e-2371
presumptive segmental plate7.78e-2371
dermomyotome7.78e-2371
trunk paraxial mesoderm7.78e-2371
dense mesenchyme tissue1.76e-2273
paraxial mesoderm2.09e-2272
presumptive paraxial mesoderm2.09e-2272
artery1.00e-2142
arterial blood vessel1.00e-2142
arterial system1.00e-2142
cardiovascular system2.27e-21109
vessel5.77e-2168
unilaminar epithelium6.86e-20148
skeletal muscle tissue7.83e-2062
striated muscle tissue7.83e-2062
myotome7.83e-2062
epithelial tube open at both ends9.46e-2059
blood vessel9.46e-2059
blood vasculature9.46e-2059
vascular cord9.46e-2059
circulatory system1.55e-19112
muscle tissue4.67e-1964
musculature4.67e-1964
musculature of body4.67e-1964
splanchnic layer of lateral plate mesoderm9.68e-1983
systemic artery4.15e-1733
systemic arterial system4.15e-1733
epithelial tube1.08e-16117
trunk mesenchyme6.72e-16122
cell layer1.89e-14309
epithelium9.29e-14306
mesenchyme6.06e-13160
entire embryonic mesenchyme6.06e-13160
organism subdivision8.67e-13264
trunk2.82e-11199
aorta1.25e-0921
aortic system1.25e-0921
anatomical system1.33e-09624
anatomical group2.13e-09625
surface structure4.90e-0999
multi-cellular organism7.48e-09656
mesoderm1.17e-08315
mesoderm-derived structure1.17e-08315
presumptive mesoderm1.17e-08315
integument2.64e-0846
integumental system2.64e-0846
anatomical conduit2.56e-07240
skin of body4.25e-0741
simple squamous epithelium4.41e-0722
blood vessel smooth muscle5.93e-0710
arterial system smooth muscle5.93e-0710
artery smooth muscle tissue5.93e-0710
aorta smooth muscle tissue5.93e-0710
Disease
Ontology termp-valuen
ovarian cancer1.59e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.11.64148
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.11.62115
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0834661
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.11.55947
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.11.36919
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.195278
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.21.34467
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.11.31345
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.12.37721
MA0160.10.871361
MA0161.10
MA0162.10.8915
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.22.08754
MA0079.20.09178
MA0102.21.88331
MA0258.11.29138
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105137.971147625824820.001974187055288560.0115288594200001
EGR1#195834.988179094810140.008056488137383440.0320928966580284
FOS#235338.99795530889440.001372499272417130.00898248223536612
FOSL1#8061339.7135797163731.59554825631833e-050.000371378347095231
JUN#3725312.51282919233630.0005103313992726250.00444561689954406
JUNB#3726330.61063265982113.4847716247536e-050.000680909380201387
JUND#372736.994663941871030.002921845042734990.0156916015024528
SMARCC1#6599343.66335931963151.20046018043203e-050.000301962574142921



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.