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Coexpression cluster:C615

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Full id: C615_CD19_Neutrophils_Eosinophils_CD4_CD8_Natural_blood



Phase1 CAGE Peaks

Hg19::chr10:69644837..69644886,-p@chr10:69644837..69644886
-
Hg19::chr11:65407297..65407328,+p6@SIPA1
Hg19::chr16:30662050..30662078,+p5@PRR14
Hg19::chr19:4067174..4067200,-p9@ZBTB7A
Hg19::chr19:49842573..49842602,+p@chr19:49842573..49842602
+
Hg19::chr19:49843537..49843640,+p@chr19:49843537..49843640
+
Hg19::chr19:58694742..58694800,+p2@ZNF274
Hg19::chr20:18774702..18774738,+p1@LOC100270804
Hg19::chr20:5591566..5591598,-p2@GPCPD1
Hg19::chr22:38073174..38073215,-p@chr22:38073174..38073215
-
Hg19::chr2:197890756..197890770,-p@chr2:197890756..197890770
-
Hg19::chr2:198175495..198175525,-p1@ANKRD44
Hg19::chr4:78740511..78740539,-p1@CNOT6L
Hg19::chr8:101322317..101322334,-p2@RNF19A


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005515protein binding0.0233065486029287
GO:0046582Rap GTPase activator activity0.0233065486029287
GO:0016564transcription repressor activity0.0233065486029287
GO:0035035histone acetyltransferase binding0.026484607892999



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.03e-54140
hematopoietic stem cell2.74e-54172
angioblastic mesenchymal cell2.74e-54172
hematopoietic oligopotent progenitor cell1.98e-50165
hematopoietic multipotent progenitor cell1.98e-50165
hematopoietic cell1.29e-49182
hematopoietic lineage restricted progenitor cell5.55e-45124
nongranular leukocyte1.67e-43119
myeloid cell1.85e-26112
common myeloid progenitor1.85e-26112
myeloid leukocyte9.53e-2676
lymphocyte3.34e-2253
common lymphoid progenitor3.34e-2253
granulocyte monocyte progenitor cell3.50e-2271
lymphoid lineage restricted progenitor cell5.88e-2252
myeloid lineage restricted progenitor cell2.37e-2170
macrophage dendritic cell progenitor1.58e-1965
CD14-positive, CD16-negative classical monocyte3.24e-1942
monopoietic cell7.85e-1963
monocyte7.85e-1963
monoblast7.85e-1963
promonocyte7.85e-1963
classical monocyte7.20e-1745
mature alpha-beta T cell9.19e-1218
alpha-beta T cell9.19e-1218
immature T cell9.19e-1218
mature T cell9.19e-1218
immature alpha-beta T cell9.19e-1218
lymphocyte of B lineage6.32e-1124
pro-B cell6.32e-1124
T cell1.94e-1025
pro-T cell1.94e-1025
B cell5.72e-0914
CD8-positive, alpha-beta T cell7.50e-0811
Uber Anatomy
Ontology termp-valuen
hematopoietic system5.63e-28102
blood island5.63e-28102
hemolymphoid system1.32e-25112
adult organism5.39e-22115
bone marrow3.71e-1880
bone element1.64e-1686
immune system4.75e-13115
skeletal element6.78e-12101
skeletal system6.78e-12101
blood2.44e-0815
haemolymphatic fluid2.44e-0815
organism substance2.44e-0815
neural tube1.70e-0757
neural rod1.70e-0757
future spinal cord1.70e-0757
neural keel1.70e-0757


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187682.866946132398510.002341652686038430.0132739831131767
EGR1#195872.494089547405070.01176051944619070.0428576325217458
ELF1#1997103.041498542005380.0001960883233653430.00235800442187139
ETS1#211353.474557472215120.01035429153034180.0384481210672461
GABPB1#255363.029007358363790.008662589686335660.0329717629742779
HEY1#2346282.308634881774690.009675141623558980.0364091131057139
HMGN3#932463.505091881435970.004171546858416660.0198701168633667
JUND#372762.997713117944730.009116463920820550.034495647818071
PAX5#507962.858385227647640.01150092546436290.0420672137629178
POLR2A#5430131.994063663946780.0003845688903765380.00377445638023073
POU2F2#545253.252187163479470.01362351556019460.0480717055744024
TAF1#6872112.626679224514160.0002393683783156760.00260573213080163
TBP#690892.382924013133390.003811761126235160.0188252007501241
YY1#752882.806383285630770.002702639654839410.0148667956869152
ZBTB7A#5134184.201091033071940.0001628644135476470.00202661700065562



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.