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Coexpression cluster:C805


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Full id: C805_granulocyte_acute_CD14_Eosinophils_Dendritic_Peripheral_Basophils

Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0047696beta-adrenergic receptor kinase activity0.0211892456542427
GO:0022401adaptation of signaling pathway0.0211892456542427
GO:0002029desensitization of G-protein coupled receptor protein signaling pathway0.0211892456542427
GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway0.0211892456542427
GO:0002026regulation of the force of heart contraction0.0296583952027233
GO:0004703G-protein coupled receptor kinase activity0.0458796346707017

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell1.58e-76168
angioblastic mesenchymal cell1.58e-76168
hematopoietic cell6.17e-72177
hematopoietic oligopotent progenitor cell3.02e-71161
hematopoietic multipotent progenitor cell3.02e-71161
hematopoietic lineage restricted progenitor cell4.01e-54120
nongranular leukocyte6.71e-54115
myeloid cell6.08e-46108
common myeloid progenitor6.08e-46108
myeloid leukocyte7.22e-3672
granulocyte monocyte progenitor cell1.92e-3267
myeloid lineage restricted progenitor cell3.37e-3166
macrophage dendritic cell progenitor1.44e-2961
monopoietic cell3.03e-2959
defensive cell3.84e-2748
classical monocyte3.36e-2542
CD14-positive, CD16-negative classical monocyte3.36e-2542
common lymphoid progenitor2.95e-2153
nucleate cell3.56e-2155
lymphoid lineage restricted progenitor cell6.13e-2152
T cell2.05e-1025
pro-T cell2.05e-1025
lymphocyte of B lineage2.06e-1024
pro-B cell2.06e-1024
mature alpha-beta T cell1.60e-0918
alpha-beta T cell1.60e-0918
immature T cell1.60e-0918
mature T cell1.60e-0918
immature alpha-beta T cell1.60e-0918
B cell1.42e-0814
stuff accumulating cell6.84e-0887
intermediate monocyte4.83e-079
CD14-positive, CD16-positive monocyte4.83e-079
mesenchymal cell6.08e-07354
CD8-positive, alpha-beta T cell8.50e-0711
Uber Anatomy
Ontology termp-valuen
hematopoietic system5.02e-3898
blood island5.02e-3898
hemolymphoid system3.96e-33108
bone marrow1.12e-2876
immune system1.56e-2693
bone element6.20e-2582
skeletal element2.00e-1990
adult organism2.99e-19114
skeletal system2.17e-15100
lateral plate mesoderm1.14e-10203
haemolymphatic fluid1.77e-0715
organism substance1.77e-0715
Ontology termp-valuen
hematologic cancer1.22e-1251
immune system cancer1.22e-1251
myeloid leukemia1.59e-1031

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs

JASPAR motifs



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)


Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.