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Coexpression cluster:C981


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Full id: C981_choriocarcinoma_chorionic_pancreatic_placenta_amniotic_vagina_MCF7

Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0042415norepinephrine metabolic process0.00350288472860002
GO:0042421norepinephrine biosynthetic process0.00350288472860002
GO:0048485sympathetic nervous system development0.00467044422881899
GO:0048483autonomic nervous system development0.00525417242194267
GO:0042423catecholamine biosynthetic process0.0140096828629117
GO:0042136neurotransmitter biosynthetic process0.0186779273270035
GO:0043627response to estrogen stimulus0.0198400389723906
GO:0006584catecholamine metabolic process0.0198400389723906
GO:0018958phenol metabolic process0.0198400389723906
GO:0001709cell fate determination0.0198400389723906
GO:0042133neurotransmitter metabolic process0.0198400389723906
GO:0042401biogenic amine biosynthetic process0.0198400389723906
GO:0048545response to steroid hormone stimulus0.019928932469712
GO:0042398amino acid derivative biosynthetic process0.0200707908551284
GO:0042446hormone biosynthetic process0.0200707908551284
GO:0042035regulation of cytokine biosynthetic process0.0248104870521948
GO:0042089cytokine biosynthetic process0.0248104870521948
GO:0042107cytokine metabolic process0.0248104870521948
GO:0045165cell fate commitment0.0248104870521948
GO:0006576biogenic amine metabolic process0.0248104870521948
GO:0009725response to hormone stimulus0.0248104870521948
GO:0001505regulation of neurotransmitter levels0.0248104870521948
GO:0042445hormone metabolic process0.0262372211764849
GO:0006575amino acid derivative metabolic process0.0262372211764849
GO:0001816cytokine production0.0316138775295708
GO:0009309amine biosynthetic process0.0320091784237637
GO:0050954sensory perception of mechanical stimulus0.032963518626922
GO:0007605sensory perception of sound0.032963518626922
GO:0044271nitrogen compound biosynthetic process0.0354356923500112
GO:0006725aromatic compound metabolic process0.0414706298862488
GO:0006417regulation of translation0.0414706298862488
GO:0031326regulation of cellular biosynthetic process0.0434401632898297
GO:0009889regulation of biosynthetic process0.0457994655493675
GO:0045893positive regulation of transcription, DNA-dependent0.0457994655493675

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
extraembryonic membrane2.83e-1114
membranous layer2.83e-1114
adult organism6.02e-09115
extraembryonic structure2.87e-0724

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs

JASPAR motifs



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.