MCL coexpression mm9:1118

Phase1 CAGE Peaks

	Short description
Mm9::chr13:55629806..55629810,-	p3@Dok3
Mm9::chr15:101978306..101978332,+	p@chr15:101978306..101978332 +
Mm9::chr18:61696440..61696459,-	p3@Arhgef37
Mm9::chr1:180919481..180919491,-	p4@Smyd3
Mm9::chr9:124016705..124016726,+	p2@Ccr2
Mm9::chr9:124016779..124016787,+	p4@Ccr2
Mm9::chr9:124016849..124016905,+	p1@Ccr2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005158	insulin receptor binding	0.0376777099248647
GO:0018024	histone-lysine N-methyltransferase activity	0.0376777099248647
GO:0016278	lysine N-methyltransferase activity	0.0376777099248647
GO:0016279	protein-lysine N-methyltransferase activity	0.0376777099248647
GO:0016493	C-C chemokine receptor activity	0.0376777099248647
GO:0019957	C-C chemokine binding	0.0376777099248647
GO:0042054	histone methyltransferase activity	0.0376777099248647
GO:0001637	G-protein chemoattractant receptor activity	0.0376777099248647
GO:0004950	chemokine receptor activity	0.0376777099248647
GO:0019233	sensory perception of pain	0.0376777099248647
GO:0019956	chemokine binding	0.0376777099248647
GO:0008170	N-methyltransferase activity	0.0420646526111621
GO:0008276	protein methyltransferase activity	0.0420646526111621

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
stomach	3.77e-07	16
food storage organ	3.77e-07	16

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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