MCL coexpression mm9:219
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0006953 | acute-phase response | 0.0275006151367407 |
| GO:0035300 | inositol trisphosphate 5/6-kinase activity | 0.0278036487152797 |
| GO:0051765 | inositol tetrakisphosphate kinase activity | 0.0278036487152797 |
| GO:0047325 | inositol tetrakisphosphate 1-kinase activity | 0.0278036487152797 |
| GO:0016176 | superoxide-generating NADPH oxidase activator activity | 0.0280353446395364 |
| GO:0043647 | inositol phosphate metabolic process | 0.0280353446395364 |
| GO:0032957 | inositol trisphosphate metabolic process | 0.0280353446395364 |
| GO:0002526 | acute inflammatory response | 0.0280353446395364 |
| GO:0006950 | response to stress | 0.0307422181886886 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| brush border epithelial cell | 6.41e-22 | 6 |
| gut absorptive cell | 6.41e-22 | 6 |
| absorptive cell | 6.41e-22 | 6 |
| enterocyte | 6.41e-22 | 6 |
| intestinal epithelial cell | 4.02e-19 | 9 |
| epithelial cell of alimentary canal | 4.02e-19 | 9 |
| columnar/cuboidal epithelial cell | 1.02e-18 | 7 |
| epithelial cell | 2.95e-13 | 25 |
| transporting cell | 2.10e-12 | 3 |
| M cell of gut | 2.10e-12 | 3 |
| endo-epithelial cell | 3.91e-11 | 15 |
| endodermal cell | 3.92e-08 | 20 |
| Ontology term | p-value | n |
|---|---|---|
| mucosa | 2.57e-39 | 15 |
| intestine | 3.10e-34 | 31 |
| intestinal mucosa | 1.77e-32 | 13 |
| anatomical wall | 1.77e-32 | 13 |
| wall of intestine | 1.77e-32 | 13 |
| gastrointestinal system mucosa | 1.77e-32 | 13 |
| organ component layer | 1.14e-23 | 24 |
| gastrointestinal system | 1.88e-21 | 47 |
| epithelium of mucosa | 4.02e-19 | 9 |
| gastrointestinal system epithelium | 4.02e-19 | 9 |
| intestinal epithelium | 4.02e-19 | 9 |
| simple columnar epithelium | 1.70e-15 | 11 |
| small intestine | 3.43e-15 | 4 |
| ileal mucosa | 2.71e-12 | 3 |
| ileum | 2.71e-12 | 3 |
| mucosa of small intestine | 2.71e-12 | 3 |
| wall of small intestine | 2.71e-12 | 3 |
| digestive system | 8.34e-09 | 116 |
| digestive tract | 8.34e-09 | 116 |
| primitive gut | 8.34e-09 | 116 |
| endoderm-derived structure | 1.36e-08 | 118 |
| endoderm | 1.36e-08 | 118 |
| presumptive endoderm | 1.36e-08 | 118 |
| gut-associated lymphoid tissue | 1.95e-08 | 2 |
| mucosa-associated lymphoid tissue | 1.95e-08 | 2 |
| lymphoid tissue | 1.95e-08 | 2 |
| subdivision of digestive tract | 7.66e-07 | 114 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.00818258 |
| MA0004.1 | 0.0463278 |
| MA0006.1 | 0.13339 |
| MA0007.1 | 0.658457 |
| MA0009.1 | 0.28789 |
| MA0014.1 | 0.0154064 |
| MA0017.1 | 0.840615 |
| MA0019.1 | 0.497064 |
| MA0024.1 | 0.256408 |
| MA0025.1 | 0.472823 |
| MA0027.1 | 1.82121 |
| MA0028.1 | 0.0536096 |
| MA0029.1 | 0.241245 |
| MA0030.1 | 0.245792 |
| MA0031.1 | 0.221516 |
| MA0038.1 | 0.698324 |
| MA0040.1 | 0.29711 |
| MA0041.1 | 0.492816 |
| MA0042.1 | 0.243023 |
| MA0043.1 | 0.361422 |
| MA0046.1 | 0.314603 |
| MA0048.1 | 0.0514729 |
| MA0050.1 | 0.816849 |
| MA0051.1 | 0.354431 |
| MA0052.1 | 0.303096 |
| MA0055.1 | 0.000904837 |
| MA0056.1 | 0 |
| MA0057.1 | 0.0162903 |
| MA0058.1 | 0.0213244 |
| MA0059.1 | 0.0239063 |
| MA0060.1 | 0.0174667 |
| MA0061.1 | 0.762709 |
| MA0063.1 | 0 |
| MA0066.1 | 0.328556 |
| MA0067.1 | 0.568484 |
| MA0068.1 | 0.00124235 |
| MA0069.1 | 0.303349 |
| MA0070.1 | 0.803064 |
| MA0071.1 | 0.215192 |
| MA0072.1 | 1.43711 |
| MA0073.1 | 1.39938e-12 |
| MA0074.1 | 1.48852 |
| MA0076.1 | 0.0161593 |
| MA0077.1 | 2.1191 |
| MA0078.1 | 0.79512 |
| MA0081.1 | 0.533447 |
| MA0083.1 | 0.360799 |
| MA0084.1 | 2.01686 |
| MA0087.1 | 0.873394 |
| MA0088.1 | 0.0315836 |
| MA0089.1 | 0 |
| MA0090.1 | 0.333785 |
| MA0091.1 | 0.0506469 |
| MA0092.1 | 0.33434 |
| MA0093.1 | 0.0119855 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.0784991 |
| MA0101.1 | 0.795693 |
| MA0103.1 | 1.23925 |
| MA0105.1 | 0.302934 |
| MA0106.1 | 0.40952 |
| MA0107.1 | 0.861369 |
| MA0108.2 | 1.61188 |
| MA0109.1 | 0 |
| MA0111.1 | 0.0401376 |
| MA0113.1 | 0.747569 |
| MA0114.1 | 0.510981 |
| MA0115.1 | 2.5604 |
| MA0116.1 | 0.471029 |
| MA0117.1 | 0.33849 |
| MA0119.1 | 0.109947 |
| MA0122.1 | 0.353887 |
| MA0124.1 | 0.522168 |
| MA0125.1 | 0.459209 |
| MA0130.1 | 0 |
| MA0131.1 | 0.163115 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.390343 |
| MA0136.1 | 0.308328 |
| MA0139.1 | 0.0362598 |
| MA0140.1 | 0.569543 |
| MA0141.1 | 0.40191 |
| MA0142.1 | 0.211884 |
| MA0143.1 | 0.785571 |
| MA0144.1 | 0.32677 |
| MA0145.1 | 0.0399505 |
| MA0146.1 | 0.00357915 |
| MA0147.1 | 0.0932973 |
| MA0148.1 | 0.0516927 |
| MA0149.1 | 0.510557 |
| MA0062.2 | 0.018869 |
| MA0035.2 | 0.978521 |
| MA0039.2 | 0.00551455 |
| MA0138.2 | 0.158423 |
| MA0002.2 | 0.486186 |
| MA0137.2 | 0.966054 |
| MA0104.2 | 0.0467404 |
| MA0047.2 | 0.104862 |
| MA0112.2 | 0.135049 |
| MA0065.2 | 0.606287 |
| MA0150.1 | 0.658136 |
| MA0151.1 | 0 |
| MA0152.1 | 0.696832 |
| MA0153.1 | 0.403751 |
| MA0154.1 | 0.764855 |
| MA0155.1 | 0.106371 |
| MA0156.1 | 0.372842 |
| MA0157.1 | 0.191171 |
| MA0158.1 | 0 |
| MA0159.1 | 0.103412 |
| MA0160.1 | 0.433091 |
| MA0161.1 | 0 |
| MA0162.1 | 0.0145667 |
| MA0163.1 | 9.58631e-07 |
| MA0164.1 | 0.092587 |
| MA0080.2 | 0.343538 |
| MA0018.2 | 0.0971053 |
| MA0099.2 | 0.915183 |
| MA0079.2 | 2.49616e-13 |
| MA0102.2 | 0.917775 |
| MA0258.1 | 0.683745 |
| MA0259.1 | 0.083201 |
| MA0442.1 | 0 |
