MCL coexpression mm9:489

Phase1 CAGE Peaks

	Short description
Mm9::chr11:58191043..58191048,+	p@chr11:58191043..58191048 +
Mm9::chr11:62574529..62574553,+	p1@ENSMUST00000128292
Mm9::chr17:28954648..28954666,+	p@chr17:28954648..28954666 +
Mm9::chr17:28954680..28954694,+	p@chr17:28954680..28954694 +
Mm9::chr19:41068744..41068762,-	p5@Blnk
Mm9::chr19:41068768..41068779,-	p6@Blnk
Mm9::chr3:128928440..128928460,-	p@chr3:128928440..128928460 -
Mm9::chr5:148118614..148118625,-	p4@Cdx2
Mm9::chr5:148118639..148118715,-	p1@Cdx2
Mm9::chr6:108482619..108482640,-	p@chr6:108482619..108482640 -
Mm9::chr6:135312399..135312415,+	p@chr6:135312399..135312415 +
Mm9::chr6:48845213..48845232,+	p4@Abp1
Mm9::chr7:52596120..52596147,-	p3@Ppfia3
Mm9::chr8:77397026..77397036,+	p6@Isx
Mm9::chr9:60661477..60661512,+	p@chr9:60661477..60661512 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015898	amiloride transport	0.0293102503698022
GO:0048038	quinone binding	0.0439557408918446
GO:0008131	amine oxidase activity	0.0488290092672435

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
intestinal epithelial cell	2.56e-11	9
epithelial cell of alimentary canal	2.56e-11	9
brush border epithelial cell	2.62e-08	6
gut absorptive cell	2.62e-08	6
absorptive cell	2.62e-08	6
enterocyte	2.62e-08	6
columnar/cuboidal epithelial cell	5.89e-07	7

Uber Anatomy

Ontology term	p-value	n
intestine	1.12e-34	31
gastrointestinal system	5.54e-29	47
mucosa	1.34e-18	15
intestinal mucosa	2.44e-16	13
anatomical wall	2.44e-16	13
wall of intestine	2.44e-16	13
gastrointestinal system mucosa	2.44e-16	13
epithelium of mucosa	2.56e-11	9
gastrointestinal system epithelium	2.56e-11	9
intestinal epithelium	2.56e-11	9
organ component layer	4.40e-11	24
simple columnar epithelium	7.68e-09	11
endoderm-derived structure	5.61e-07	118
endoderm	5.61e-07	118
presumptive endoderm	5.61e-07	118
digestive system	9.01e-07	116
digestive tract	9.01e-07	116
primitive gut	9.01e-07	116

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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