UBERON:0002495
From FANTOM5_SSTAR
| Name: | long bone | ||
|---|---|---|---|
| Definition: | "those that are longer than they are wide, and grow primarily by elongation of the diaphysis, with an epiphysis at the ends of the growing bone. The ends of epiphyses are covered with a hyaline cartilage ('articular cartilage'). The longitudinal growth of long bones is a result of endochondral ossification at the epiphyseal plate. Bone growth in length is stimulated by the production of growth hormone (GH), a secretion of the anterior lobe of the pituitary gland. The long bones include the femurs, tibias, and fibulas of the legs, the humeri, radii, and ulnas of the arms, metacarpals and metatarsals of the hands and feet, and the phalanges of the fingers and toes. The long bones of the human leg comprise nearly half of adult height. The other primary skeletal component of height is the spine and skull. The outside of the bone consists of a layer of connective tissue called the periosteum. Additionally, the outer shell of the long bone is compact bone, then a deeper layer of cancellous bone (spongy bone) which contains red bone marrow. The interior part of the long bone is the medullary cavity with the inner core of the bone cavity being composed of (in adults) of yellow marrow. There are five general classifications of bones: (1) Long bones, (2) Short bones, (3) Flat bones, (4) Irregular bones, and (5) Sesamoid bones[WP]." [Wikipedia:Long_bone] | ||
| Xrefs: |
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| Comments: | Endochondral_ossification is an essential process during the rudimentary formation of long bones, with the exception of the clavicle[Wikipedia:Endochondral_ossification]. The medial and and lateral ends undergo EO, the mid-portion is formed by a process with features of EO & IO (the process is shared by the mandible)[ISBN:9780397517251] | ||
| Alt_id: | UBERON:MA_0002802-FMA_7474 | ||
| Subset: | uberon_slim |
Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | UBERON:0001474(bone element) |
|---|---|
| part_of: | UBERON:0002091(appendicular skeleton) |
Children
| is a: | UBERON:0003606 (limb long bone) |
|---|
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology
Mouse (Mus musculus)
- 1350-25C3 (bone (os femoris), neonate N20)
- 1525-43A6 (bone (os femoris), neonate N16)
- 1985-43F5 (bone (os femoris), neonate N02)
- 56-12G2 (bone (os femoris), adult)
Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002495 (long bone), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 3.4e-49 | FFCP PHASE1:Mm9::chr11:77624716..77624729,+#_acebd46883c9d44463c5dacaa72d7a98 | p26@Myo18a |
| 3.4e-49 | FFCP PHASE2:Mm9::chr11:77624716..77624729,+#_acebd46883c9d44463c5dacaa72d7a98 | p26@Myo18a |
| 4.96e-49 | FFCP PHASE1:Mm9::chr2:32482372..32482381,+#_d022df6d1d793061171e865febccf2fa | p@chr2:32482372..32482381, + |
| 4.96e-49 | FFCP PHASE2:Mm9::chr8:75097542..75097549,+#_d022df6d1d793061171e865febccf2fa | p@chr8:75097542..75097549, + |
| 4.96e-49 | FFCP PHASE1:Mm9::chr9:21934585..21934591,-#_d022df6d1d793061171e865febccf2fa | p@chr9:21934585..21934591, - |
| 4.96e-49 | FFCP PHASE2:Mm9::chr2:32482372..32482381,+#_d022df6d1d793061171e865febccf2fa | p@chr2:32482372..32482381, + |
| 4.96e-49 | FFCP PHASE2:Mm9::chr9:21934585..21934591,-#_d022df6d1d793061171e865febccf2fa | p@chr9:21934585..21934591, - |
| 4.96e-49 | FFCP PHASE1:Mm9::chr8:75097542..75097549,+#_d022df6d1d793061171e865febccf2fa | p@chr8:75097542..75097549, + |
| 3.15e-44 | FFCP PHASE1:Mm9::chr6:51525810..51525817,+#_f2c0d0a586dd08dee0ae9fd1a8508c97 | p@chr6:51525810..51525817, + |
| 3.15e-44 | FFCP PHASE2:Mm9::chr6:51525810..51525817,+#_f2c0d0a586dd08dee0ae9fd1a8508c97 | p@chr6:51525810..51525817, + |
| 9.78e-40 | FFCP PHASE1:Mm9::chr19:4876870..4876880,-#_9a109889d33edbdc4a67fa4ce3546449 | p@chr19:4876870..4876880, - |
| 9.78e-40 | FFCP PHASE2:Mm9::chr19:4876870..4876880,-#_9a109889d33edbdc4a67fa4ce3546449 | p@chr19:4876870..4876880, - |
| 1.15e-39 | FFCP PHASE2:Mm9::chr1:174140324..174140335,-#_eb4564512297922faeee528703b6a5a9 | p@chr1:174140324..174140335, - |
| 1.15e-39 | FFCP PHASE1:Mm9::chr1:174140324..174140335,-#_eb4564512297922faeee528703b6a5a9 | p@chr1:174140324..174140335, - |
| 1.15e-39 | FFCP PHASE2:Mm9::chr11:67063327..67063335,+#_eb4564512297922faeee528703b6a5a9 | p@chr11:67063327..67063335, + |
| 1.15e-39 | FFCP PHASE1:Mm9::chr16:24096441..24096449,+#_eb4564512297922faeee528703b6a5a9 | p@chr16:24096441..24096449, + |
| 1.15e-39 | FFCP PHASE1:Mm9::chr6:4490674..4490679,+#_eb4564512297922faeee528703b6a5a9 | p@chr6:4490674..4490679, + |
| 1.15e-39 | FFCP PHASE2:Mm9::chr6:4490674..4490679,+#_eb4564512297922faeee528703b6a5a9 | p@chr6:4490674..4490679, + |
| 1.15e-39 | FFCP PHASE1:Mm9::chr11:67063327..67063335,+#_eb4564512297922faeee528703b6a5a9 | p@chr11:67063327..67063335, + |
| 1.15e-39 | FFCP PHASE2:Mm9::chr16:24096441..24096449,+#_eb4564512297922faeee528703b6a5a9 | p@chr16:24096441..24096449, + |
| 1.55e-39 | FFCP PHASE2:Mm9::chr1:174143249..174143260,-#_c55e3fa6e653d8ef285cdc5faf09e852 | p@chr1:174143249..174143260, - |
| 1.55e-39 | FFCP PHASE1:Mm9::chr1:174143249..174143260,-#_c55e3fa6e653d8ef285cdc5faf09e852 | p@chr1:174143249..174143260, - |
| 3.03e-39 | FFCP PHASE1:Mm9::chr6:51525869..51525891,+#_6e921f6e360495d33d9c25d659c5ce14 | p@chr6:51525869..51525891, + |
| 3.03e-39 | FFCP PHASE2:Mm9::chr6:51525869..51525891,+#_6e921f6e360495d33d9c25d659c5ce14 | p@chr6:51525869..51525891, + |
| 9.31e-39 | FFCP PHASE2:Mm9::chr11:102130083..102130092,+#_fc3321de3e20c908d1f1f2e2d98c85de | p3@Asb16 |
| 9.31e-39 | FFCP PHASE1:Mm9::chr11:102130083..102130092,+#_fc3321de3e20c908d1f1f2e2d98c85de | p3@Asb16 |
| 2.41e-35 | FFCP PHASE1:Mm9::chr7:133604286..133604297,-#_1cad8225af33b629e54ff96282993596 | p@chr7:133604286..133604297, - |
| 2.41e-35 | FFCP PHASE2:Mm9::chr7:133604286..133604297,-#_1cad8225af33b629e54ff96282993596 | p@chr7:133604286..133604297, - |
| 2.95e-35 | FFCP PHASE2:Mm9::chr4:138365748..138365759,-#_ebc8a29cabd704b904c0fcfcb41069e3 | p5@Pla2g5 |
| 2.95e-35 | FFCP PHASE1:Mm9::chr4:138365748..138365759,-#_ebc8a29cabd704b904c0fcfcb41069e3 | p5@Pla2g5 |
| 9.53e-34 | FFCP PHASE1:Mm9::chr8:74049600..74049612,-#_a8ba166c4c35599f891211f985923a32 | p2@uc009mdq.1 |
| 9.53e-34 | FFCP PHASE2:Mm9::chr8:74049600..74049612,-#_a8ba166c4c35599f891211f985923a32 | p2@uc009mdq.1 |
| 1.23e-33 | FFCP PHASE1:Mm9::chr2:164773241..164773248,+#_f5233def2050c869025985f8ddaafe68 | p3@Mmp9 |
| 1.23e-33 | FFCP PHASE2:Mm9::chr2:164773241..164773248,+#_f5233def2050c869025985f8ddaafe68 | p3@Mmp9 |
| 1.58e-33 | FFCP PHASE1:Mm9::chr7:3567707..3567718,-#_34212ec7fd839f86b67b7a7d07e2be3e | p2@Oscar |
| 1.58e-33 | FFCP PHASE2:Mm9::chr7:3567707..3567718,-#_34212ec7fd839f86b67b7a7d07e2be3e | p2@Oscar |
| 1.58e-33 | FFCP PHASE1:Mm9::chr1:166815111..166815121,-#_34212ec7fd839f86b67b7a7d07e2be3e | p@chr1:166815111..166815121, - |
| 1.58e-33 | FFCP PHASE2:Mm9::chr1:166815111..166815121,-#_34212ec7fd839f86b67b7a7d07e2be3e | p@chr1:166815111..166815121, - |
| 2.04e-33 | FFCP PHASE1:Mm9::chr11:75409652..75409664,+#_3a59b1e0c091d20bf18657866c3fbf7e | p@chr11:75409652..75409664, + |
| 2.04e-33 | FFCP PHASE2:Mm9::chr11:75409652..75409664,+#_3a59b1e0c091d20bf18657866c3fbf7e | p@chr11:75409652..75409664, + |
| 2.04e-33 | FFCP PHASE1:Mm9::chr9:70799951..70799962,-#_3a59b1e0c091d20bf18657866c3fbf7e | p4@Lipc |
| 2.04e-33 | FFCP PHASE2:Mm9::chr9:70799951..70799962,-#_3a59b1e0c091d20bf18657866c3fbf7e | p4@Lipc |
| 3.38e-33 | FFCP PHASE2:Mm9::chr15:102196702..102196713,-#_765d35828b1149444e6d1b78bbaafda4 | p6@Sp7 |
| 3.38e-33 | FFCP PHASE1:Mm9::chr15:102196702..102196713,-#_765d35828b1149444e6d1b78bbaafda4 | p6@Sp7 |
| 7.17e-33 | FFCP PHASE1:Mm9::chr8:126415826..126415839,+#_84a9e4181692664f3077c0738fe93092 | p@chr8:126415826..126415839, + |
| 7.17e-33 | FFCP PHASE2:Mm9::chr8:126415826..126415839,+#_84a9e4181692664f3077c0738fe93092 | p@chr8:126415826..126415839, + |
| 7.17e-33 | FFCP PHASE1:Mm9::chr18:76271498..76271508,+#_84a9e4181692664f3077c0738fe93092 | p@chr18:76271498..76271508, + |
| 7.17e-33 | FFCP PHASE2:Mm9::chr18:76271498..76271508,+#_84a9e4181692664f3077c0738fe93092 | p@chr18:76271498..76271508, + |
| 2.67e-30 | FFCP PHASE1:Mm9::chr2:32482387..32482399,+#_6236360f0ffa96e36c4a04de94024f73 | p@chr2:32482387..32482399, + |
| 2.67e-30 | FFCP PHASE2:Mm9::chr2:32482387..32482399,+#_6236360f0ffa96e36c4a04de94024f73 | p@chr2:32482387..32482399, + |
| 1.1e-29 | FFCP PHASE2:Mm9::chr12:70396969..70396979,+#_4254a165f45fd38c3442f9f78de8bfe4 | p@chr12:70396969..70396979, + |
| 1.1e-29 | FFCP PHASE1:Mm9::chr12:70396969..70396979,+#_4254a165f45fd38c3442f9f78de8bfe4 | p@chr12:70396969..70396979, + |
| 1.1e-29 | FFCP PHASE2:Mm9::chr15:58649683..58649688,-#_4254a165f45fd38c3442f9f78de8bfe4 | p@chr15:58649683..58649688, - |
| 1.1e-29 | FFCP PHASE1:Mm9::chr15:58649683..58649688,-#_4254a165f45fd38c3442f9f78de8bfe4 | p@chr15:58649683..58649688, - |
| 1.46e-29 | FFCP PHASE2:Mm9::chr7:133590998..133591009,-#_9e8ec6931d1316c1de653c7784f62bb3 | p@chr7:133590998..133591009, - |
| 1.46e-29 | FFCP PHASE1:Mm9::chr7:133590998..133591009,-#_9e8ec6931d1316c1de653c7784f62bb3 | p@chr7:133590998..133591009, - |
| 1.73e-29 | FFCP PHASE2:Mm9::chr18:60751417..60751432,-#_6e324731079b1c4e5d82df6fdbb34620 | p2@Myoz3 |
| 1.73e-29 | FFCP PHASE1:Mm9::chr18:60751417..60751432,-#_6e324731079b1c4e5d82df6fdbb34620 | p2@Myoz3 |
| 2.42e-29 | FFCP PHASE2:Mm9::chr11:67051354..67051366,+#_746356eb8dd806aff753fc5e1976a631 | p2@Myh4 |
| 2.42e-29 | FFCP PHASE1:Mm9::chr11:67051354..67051366,+#_746356eb8dd806aff753fc5e1976a631 | p2@Myh4 |
| 7.46e-29 | FFCP PHASE2:Mm9::chr1:57155729..57155740,-#_9e4d6c51fdfbbaef9cc3a29ef10c9e57 | p@chr1:57155729..57155740, - |
| 7.46e-29 | FFCP PHASE1:Mm9::chr1:57155729..57155740,-#_9e4d6c51fdfbbaef9cc3a29ef10c9e57 | p@chr1:57155729..57155740, - |
| 9.26e-29 | FFCP PHASE2:Mm9::chr11:67056544..67056589,-#_4fbfa27d29e9060ab62340d88dcc7ade | p@chr11:67056544..67056589, - |
| 9.26e-29 | FFCP PHASE2:Mm9::chr4:43597258..43597265,-#_4fbfa27d29e9060ab62340d88dcc7ade | p1@Msmp |
| 9.26e-29 | FFCP PHASE1:Mm9::chr11:67056544..67056589,-#_4fbfa27d29e9060ab62340d88dcc7ade | p@chr11:67056544..67056589, - |
| 9.26e-29 | FFCP PHASE1:Mm9::chr4:43597258..43597265,-#_4fbfa27d29e9060ab62340d88dcc7ade | p1@Msmp |
| 1.15e-28 | FFCP PHASE2:Mm9::chrY:2858251..2858257,+#_cf5502913cbd43952f4abbbd44fa3767 | p@chrY:2858251..2858257, + |
| 1.15e-28 | FFCP PHASE2:Mm9::chr6:90552017..90552024,+#_cf5502913cbd43952f4abbbd44fa3767 | p@chr6:90552017..90552024, + |
| 1.15e-28 | FFCP PHASE1:Mm9::chr6:90552017..90552024,+#_cf5502913cbd43952f4abbbd44fa3767 | p@chr6:90552017..90552024, + |
| 1.15e-28 | FFCP PHASE1:Mm9::chrY:2858251..2858257,+#_cf5502913cbd43952f4abbbd44fa3767 | p@chrY:2858251..2858257, + |
| 1.43e-28 | FFCP PHASE2:Mm9::chr6:34436258..34436292,+#_737d51f35dec23bb5f828b9f1f5cdd28 | p@chr6:34436258..34436292, + |
| 1.43e-28 | FFCP PHASE1:Mm9::chr6:34436258..34436292,+#_737d51f35dec23bb5f828b9f1f5cdd28 | p@chr6:34436258..34436292, + |
| 2.2e-28 | FFCP PHASE2:Mm9::chr11:67069796..67069817,-#_9ce852a7a2c5ba28c18f6eabb99c1b03 | p@chr11:67069796..67069817, - |
| 2.2e-28 | FFCP PHASE1:Mm9::chr11:67069796..67069817,-#_9ce852a7a2c5ba28c18f6eabb99c1b03 | p@chr11:67069796..67069817, - |
| 2.72e-28 | FFCP PHASE2:Mm9::chr8:107702369..107702386,+#_2ee94cb9e5abc041ba569889426618c8 | p@chr8:107702369..107702386, + |
| 2.72e-28 | FFCP PHASE1:Mm9::chr8:107702369..107702386,+#_2ee94cb9e5abc041ba569889426618c8 | p@chr8:107702369..107702386, + |
| 3.45e-28 | FFCP PHASE1:Mm9::chr18:78254135..78254146,-#_c06a9765ee06a3b3a2c52a19619038dd | p1@Siglec15 |
| 3.45e-28 | FFCP PHASE2:Mm9::chr18:78254135..78254146,-#_c06a9765ee06a3b3a2c52a19619038dd | p1@Siglec15 |
| 6.5e-28 | FFCP PHASE2:Mm9::chr7:133591490..133591500,-#_05bb27fb2dd4aeaffcb1d77283027c5a | p6@Atp2a1 |
| 6.5e-28 | FFCP PHASE1:Mm9::chr7:133591490..133591500,-#_05bb27fb2dd4aeaffcb1d77283027c5a | p6@Atp2a1 |
| 8.9e-28 | FFCP PHASE1:Mm9::chr7:133591156..133591165,-#_dba25351d1ed70891c70538721e83fba | p7@Atp2a1 |
| 8.9e-28 | FFCP PHASE2:Mm9::chr7:133591156..133591165,-#_dba25351d1ed70891c70538721e83fba | p7@Atp2a1 |
| 1.42e-27 | FFCP PHASE2:Mm9::chr7:133600635..133600663,+#_baf81bc4034f5f381fed84dd9045eff5 | p@chr7:133600635..133600663, + |
| 1.42e-27 | FFCP PHASE1:Mm9::chr7:133600635..133600663,+#_baf81bc4034f5f381fed84dd9045eff5 | p@chr7:133600635..133600663, + |
| 1.42e-27 | FFCP PHASE2:Mm9::chr7:133592162..133592188,-#_baf81bc4034f5f381fed84dd9045eff5 | p@chr7:133592162..133592188, - |
| 1.42e-27 | FFCP PHASE1:Mm9::chr7:133592162..133592188,-#_baf81bc4034f5f381fed84dd9045eff5 | p@chr7:133592162..133592188, - |
| 6.75e-27 | FFCP PHASE2:Mm9::chr11:94837662..94837673,-#_d5b5d24423b577681d138278593d5e17 | p4@Sgca |
| 6.75e-27 | FFCP PHASE1:Mm9::chr11:94837662..94837673,-#_d5b5d24423b577681d138278593d5e17 | p4@Sgca |
| 1.66e-26 | FFCP PHASE1:Mm9::chr5:104754379..104754387,+#_ec4bedf0d2eae426bd52c52bce41b8f4 | p1@Mepe |
| 1.66e-26 | FFCP PHASE2:Mm9::chr5:104754379..104754387,+#_ec4bedf0d2eae426bd52c52bce41b8f4 | p1@Mepe |
| 3.47e-26 | FFCP PHASE1:Mm9::chr12:81581216..81581231,+#_6a05e37cbcbfbf5812960547e37eb9ef | p@chr12:81581216..81581231, + |
| 3.47e-26 | FFCP PHASE2:Mm9::chr16:32400888..32400899,+#_6a05e37cbcbfbf5812960547e37eb9ef | p2@Tm4sf19 |
| 3.47e-26 | FFCP PHASE1:Mm9::chr16:32400888..32400899,+#_6a05e37cbcbfbf5812960547e37eb9ef | p2@Tm4sf19 |
| 3.47e-26 | FFCP PHASE2:Mm9::chr12:81581216..81581231,+#_6a05e37cbcbfbf5812960547e37eb9ef | p@chr12:81581216..81581231, + |
| 1.12e-25 | FFCP PHASE2:Mm9::chr17:34176173..34176200,+#_9d23240a89b9f7698ee6568228ea0097 | p5@Col11a2 |
| 1.12e-25 | FFCP PHASE1:Mm9::chr15:97806574..97806585,-#_9d23240a89b9f7698ee6568228ea0097 | p@chr15:97806574..97806585, - |
| 1.12e-25 | FFCP PHASE2:Mm9::chr15:97806574..97806585,-#_9d23240a89b9f7698ee6568228ea0097 | p@chr15:97806574..97806585, - |
| 1.12e-25 | FFCP PHASE1:Mm9::chr17:34176173..34176200,+#_9d23240a89b9f7698ee6568228ea0097 | p5@Col11a2 |
| 1.36e-25 | FFCP PHASE1:Mm9::chr2:180890942..180890956,-#_7fd3b965322a0b325af9d9fcd0b04aaa | p@chr2:180890942..180890956, - |
| 1.36e-25 | FFCP PHASE1:Mm9::chr18:78254174..78254185,-#_7fd3b965322a0b325af9d9fcd0b04aaa | p2@Siglec15 |
