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Preadipocyte to adipocyte

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Series:IN_VITRO DIFFERENTIATION SERIES
Species:Human (Homo sapiens)
Genomic View:Zenbu
Expression table:[{{{tet_config}}} FILE]
Link to TET:[{{{tet_file}}} TET]
Sample providers :Peter Arner
Germ layer:{{{germ_layer}}}
Primary cells or cell line:{{{primary_cells}}}
Time span:{{{time_span}}}
Number of time points:{{{number_time_points}}}


Overview

Adipose tissue can account for between 5% (lean athletes) and 60% (morbidly obese) of total body mass, making it one of the most plastic organs in the body [8]. In response to changed nutritional status, both adipocyte cell number and size change and even under stable conditions as much as 10% of the adipocytes are turned over annually [1,2]. Thus the birth of new adipocytes from precursor cells (adipogenesis) is central for a functional fat tissue.

References:
[1] Dynamics of fat cell turnover in humans. Spalding KL et al, Nature, 2008, vol 453, p783-787. PMID:18454136
[2] Adipocyte turnover:relevance to human adiopose tissue morphology- Arner E et al, Diabetes, 2010,59(1):105-9. PMID:19846802

Sample description

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Quality control

{{{TCQuality_control}}}

Profiled time course samples

Only samples that passed quality controls (Arner et al. 2015) are shown here. The entire set of samples are downloadable from FANTOM5 human / mouse samples



13019-139D4Adipocyte differentiationday04donor1
13020-139D5Adipocyte differentiationday08donor1
13021-139D6Adipocyte differentiationday12donor1
13022-139D7Adipocyte differentiationday04donor2
13023-139D8Adipocyte differentiationday08donor2
13024-139D9Adipocyte differentiationday12donor2
13025-139E1Adipocyte differentiationday04donor3
13026-139E2Adipocyte differentiationday08donor3
13027-139E3Adipocyte differentiationday12donor3
13028-139E4Adipocyte differentiationday04donor4
13029-139E5Adipocyte differentiationday08donor4
13030-139E6Adipocyte differentiationday12donor4