CL:0000092
From FANTOM5_SSTAR
| Name: | osteoclast | ||
|---|---|---|---|
| Namespace: | FANTOM | ||
| Definition: | "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158] | ||
| Xrefs: |
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| Synonyms: | "chondroclast" RELATED [] | ||
| Comments: | Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0000766(myeloid leukocyte),CL:0001035(bone cell) |
|---|---|
| develops_from: | CL:0000576(monocyte) |
| part_of: | UBERON:0001474(bone element) |
Children
| derives from: | FF:0100969 (osteoclastoma cell sample),FF:0200020 (osteoclast, bone marrow-derived sample) |
|---|
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 10704-109H2 (osteoclastoma cell line:Hs 706.T)
- 10711-109H9 (fibrous histiocytoma cell line:GCT TIB-223)
- 10731-110B2
- 2379-69A1 (osteoclast, bone marrow derived)
Mouse (Mus musculus)
- 10704-109H2 (osteoclastoma cell line:Hs 706.T)
- 10711-109H9 (fibrous histiocytoma cell line:GCT TIB-223)
- 10731-110B2
- 2379-69A1 (osteoclast, bone marrow derived)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000092 (osteoclast), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 1.55e-98 | FFCP PHASE2:Hg19::chr16:77317713..77317723,+#_b903eca76d53485a4f1d302a80ba1931 | p1@CU687665 |
| 1.55e-98 | FFCP PHASE1:Hg19::chr16:77317713..77317723,+#_b903eca76d53485a4f1d302a80ba1931 | p1@CU687665 |
| 1.55e-98 | FFCP PHASE2:Hg19::chr11:101742272..101742276,-#_b903eca76d53485a4f1d302a80ba1931 | p@chr11:101742272..101742276, - |
| 1.55e-98 | FFCP PHASE1:Hg19::chr11:101742272..101742276,-#_b903eca76d53485a4f1d302a80ba1931 | p@chr11:101742272..101742276, - |
| 2.74e-50 | FFCP PHASE1:Hg19::chr18:71197490..71197495,-#_33220fce424e59c6ca585a69a9fb1376 | p@chr18:71197490..71197495, - |
| 2.74e-50 | FFCP PHASE2:Hg19::chr16:51670868..51670880,-#_33220fce424e59c6ca585a69a9fb1376 | p@chr16:51670868..51670880, - |
| 2.74e-50 | FFCP PHASE2:Hg19::chr11:81551043..81551054,-#_33220fce424e59c6ca585a69a9fb1376 | p@chr11:81551043..81551054, - |
| 2.74e-50 | FFCP PHASE1:Hg19::chr16:51670868..51670880,-#_33220fce424e59c6ca585a69a9fb1376 | p@chr16:51670868..51670880, - |
| 2.74e-50 | FFCP PHASE1:Hg19::chr11:81551043..81551054,-#_33220fce424e59c6ca585a69a9fb1376 | p@chr11:81551043..81551054, - |
| 2.74e-50 | FFCP PHASE2:Hg19::chr5:14034644..14034647,-#_33220fce424e59c6ca585a69a9fb1376 | p@chr5:14034644..14034647, - |
| 2.74e-50 | FFCP PHASE1:Hg19::chr5:14034644..14034647,-#_33220fce424e59c6ca585a69a9fb1376 | p@chr5:14034644..14034647, - |
| 2.74e-50 | FFCP PHASE2:Hg19::chr18:71197490..71197495,-#_33220fce424e59c6ca585a69a9fb1376 | p@chr18:71197490..71197495, - |
| 4.52e-50 | FFCP PHASE2:Hg19::chr3:106393655..106393659,+#_bcc611bb0a9d91b1d95cfe9aa14af906 | p@chr3:106393655..106393659, + |
| 4.52e-50 | FFCP PHASE1:Hg19::chr3:106393655..106393659,+#_bcc611bb0a9d91b1d95cfe9aa14af906 | p@chr3:106393655..106393659, + |
| 4.52e-50 | FFCP PHASE2:Hg19::chr3:45174403..45174415,+#_bcc611bb0a9d91b1d95cfe9aa14af906 | p@chr3:45174403..45174415, + |
| 4.52e-50 | FFCP PHASE2:Hg19::chr5:23952305..23952310,+#_bcc611bb0a9d91b1d95cfe9aa14af906 | p@chr5:23952305..23952310, + |
| 4.52e-50 | FFCP PHASE1:Hg19::chr3:45174403..45174415,+#_bcc611bb0a9d91b1d95cfe9aa14af906 | p@chr3:45174403..45174415, + |
| 4.52e-50 | FFCP PHASE1:Hg19::chr5:23952305..23952310,+#_bcc611bb0a9d91b1d95cfe9aa14af906 | p@chr5:23952305..23952310, + |
| 4.52e-50 | FFCP PHASE2:Hg19::chr4:34480309..34480321,-#_bcc611bb0a9d91b1d95cfe9aa14af906 | p@chr4:34480309..34480321, - |
| 4.52e-50 | FFCP PHASE1:Hg19::chr4:34480309..34480321,-#_bcc611bb0a9d91b1d95cfe9aa14af906 | p@chr4:34480309..34480321, - |
| 3.61e-34 | FFCP PHASE2:Hg19::chr4:177796841..177796851,+#_c06849cd5e3fae14cd7426a8305dd2a6 | p1@ENST00000508790 |
| 3.61e-34 | FFCP PHASE2:Hg19::chr7:119353807..119353812,-#_c06849cd5e3fae14cd7426a8305dd2a6 | p@chr7:119353807..119353812, - |
| 3.61e-34 | FFCP PHASE1:Hg19::chr4:177796841..177796851,+#_c06849cd5e3fae14cd7426a8305dd2a6 | p1@ENST00000508790 |
| 3.61e-34 | FFCP PHASE1:Hg19::chr7:119353807..119353812,-#_c06849cd5e3fae14cd7426a8305dd2a6 | p@chr7:119353807..119353812, - |
| 5.04e-34 | FFCP PHASE2:Hg19::chr8:15939682..15939688,+#_d8e3c1647d49dfbb2f4c17d1404d654f | p@chr8:15939682..15939688, + |
| 5.04e-34 | FFCP PHASE1:Hg19::chr8:15939682..15939688,+#_d8e3c1647d49dfbb2f4c17d1404d654f | p@chr8:15939682..15939688, + |
| 5.04e-34 | FFCP PHASE2:Hg19::chr10:37004821..37004852,-#_d8e3c1647d49dfbb2f4c17d1404d654f | p@chr10:37004821..37004852, - |
| 5.04e-34 | FFCP PHASE2:Hg19::chrX:132231123..132231140,-#_d8e3c1647d49dfbb2f4c17d1404d654f | p1@USP26 |
| 5.04e-34 | FFCP PHASE1:Hg19::chr10:37004821..37004852,-#_d8e3c1647d49dfbb2f4c17d1404d654f | p@chr10:37004821..37004852, - |
| 5.04e-34 | FFCP PHASE1:Hg19::chrX:132231123..132231140,-#_d8e3c1647d49dfbb2f4c17d1404d654f | p1@USP26 |
| 5.04e-34 | FFCP PHASE2:Hg19::chr4:46093758..46093781,-#_d8e3c1647d49dfbb2f4c17d1404d654f | p@chr4:46093758..46093781, - |
| 5.04e-34 | FFCP PHASE1:Hg19::chr4:46093758..46093781,-#_d8e3c1647d49dfbb2f4c17d1404d654f | p@chr4:46093758..46093781, - |
| 7.05e-34 | FFCP PHASE2:Hg19::chrX:89462083..89462089,+#_85c553399eb943d9f9d14fe1e1033c67 | p@chrX:89462083..89462089, + |
| 7.05e-34 | FFCP PHASE1:Hg19::chrX:89462083..89462089,+#_85c553399eb943d9f9d14fe1e1033c67 | p@chrX:89462083..89462089, + |
| 7.05e-34 | FFCP PHASE2:Hg19::chr11:84019133..84019135,-#_85c553399eb943d9f9d14fe1e1033c67 | p@chr11:84019133..84019135, - |
| 7.05e-34 | FFCP PHASE2:Hg19::chr6:155427848..155427862,+#_85c553399eb943d9f9d14fe1e1033c67 | p@chr6:155427848..155427862, + |
| 7.05e-34 | FFCP PHASE1:Hg19::chr6:155427848..155427862,+#_85c553399eb943d9f9d14fe1e1033c67 | p@chr6:155427848..155427862, + |
| 7.05e-34 | FFCP PHASE1:Hg19::chr11:84019133..84019135,-#_85c553399eb943d9f9d14fe1e1033c67 | p@chr11:84019133..84019135, - |
| 5.5e-31 | FFCP PHASE2:Hg19::chr3:106556598..106556609,-#_f68521af51a91f3238c0e54fb137aa1e | p@chr3:106556598..106556609, - |
| 5.5e-31 | FFCP PHASE1:Hg19::chr3:106556598..106556609,-#_f68521af51a91f3238c0e54fb137aa1e | p@chr3:106556598..106556609, - |
| 7.1e-28 | FFCP PHASE2:Hg19::chr6:68597008..68597030,-#_7e3f148977a24c49a4c7e2fb478f64d6 | p@chr6:68597008..68597030, - |
| 7.1e-28 | FFCP PHASE1:Hg19::chr6:68597008..68597030,-#_7e3f148977a24c49a4c7e2fb478f64d6 | p@chr6:68597008..68597030, - |
| 4.32e-26 | FFCP PHASE2:Hg19::chr11:81549961..81549965,-#_3d436b61f22464e3293afc5cb9600f13 | p@chr11:81549961..81549965, - |
| 4.32e-26 | FFCP PHASE1:Hg19::chr11:81549961..81549965,-#_3d436b61f22464e3293afc5cb9600f13 | p@chr11:81549961..81549965, - |
| 4.32e-26 | FFCP PHASE2:Hg19::chr5:27723923..27723927,-#_3d436b61f22464e3293afc5cb9600f13 | p@chr5:27723923..27723927, - |
| 4.32e-26 | FFCP PHASE1:Hg19::chr5:27723923..27723927,-#_3d436b61f22464e3293afc5cb9600f13 | p@chr5:27723923..27723927, - |
| 5.56e-26 | FFCP PHASE2:Hg19::chrX:89176902..89176913,+#_fcf427a9031ef6a1f81ae8af91e0d2fd | p1@TGIF2LX |
| 5.56e-26 | FFCP PHASE2:Hg19::chr5:167315847..167315852,+#_fcf427a9031ef6a1f81ae8af91e0d2fd | p@chr5:167315847..167315852, + |
| 5.56e-26 | FFCP PHASE1:Hg19::chr5:167315847..167315852,+#_fcf427a9031ef6a1f81ae8af91e0d2fd | p@chr5:167315847..167315852, + |
| 5.56e-26 | FFCP PHASE2:Hg19::chrX:124347061..124347063,-#_fcf427a9031ef6a1f81ae8af91e0d2fd | p@chrX:124347061..124347063, - |
| 5.56e-26 | FFCP PHASE1:Hg19::chrX:89176902..89176913,+#_fcf427a9031ef6a1f81ae8af91e0d2fd | p1@TGIF2LX |
| 5.56e-26 | FFCP PHASE2:Hg19::chrX:132352373..132352384,-#_fcf427a9031ef6a1f81ae8af91e0d2fd | p1@TFDP3 |
| 5.56e-26 | FFCP PHASE1:Hg19::chrX:124347061..124347063,-#_fcf427a9031ef6a1f81ae8af91e0d2fd | p@chrX:124347061..124347063, - |
| 5.56e-26 | FFCP PHASE1:Hg19::chrX:132352373..132352384,-#_fcf427a9031ef6a1f81ae8af91e0d2fd | p1@TFDP3 |
| 5.56e-26 | FFCP PHASE2:Hg19::chr5:153673183..153673186,+#_fcf427a9031ef6a1f81ae8af91e0d2fd | p@chr5:153673183..153673186, + |
| 5.56e-26 | FFCP PHASE2:Hg19::chr4:189864018..189864037,+#_fcf427a9031ef6a1f81ae8af91e0d2fd | p@chr4:189864018..189864037, + |
| 5.56e-26 | FFCP PHASE1:Hg19::chr5:153673183..153673186,+#_fcf427a9031ef6a1f81ae8af91e0d2fd | p@chr5:153673183..153673186, + |
| 5.56e-26 | FFCP PHASE1:Hg19::chr4:189864018..189864037,+#_fcf427a9031ef6a1f81ae8af91e0d2fd | p@chr4:189864018..189864037, + |
| 9.18e-26 | FFCP PHASE1:Hg19::chr18:14946224..14946236,+#_49480e96743bab033845ce4266ec09a5 | p1@FLJ44255 |
| 9.18e-26 | FFCP PHASE2:Hg19::chr7:12997533..12997536,+#_49480e96743bab033845ce4266ec09a5 | p@chr7:12997533..12997536, + |
| 9.18e-26 | FFCP PHASE1:Hg19::chr7:12997533..12997536,+#_49480e96743bab033845ce4266ec09a5 | p@chr7:12997533..12997536, + |
| 9.18e-26 | FFCP PHASE2:Hg19::chr18:14946224..14946236,+#_49480e96743bab033845ce4266ec09a5 | p1@FLJ44255 |
| 1.12e-25 | FFCP PHASE2:Hg19::chrX:55246809..55246816,+#_254b010d2b257690dc483a55542712c5 | p3@PAGE5 |
| 1.12e-25 | FFCP PHASE1:Hg19::chrX:55246809..55246816,+#_254b010d2b257690dc483a55542712c5 | p3@PAGE5 |
| 4.89e-23 | FFCP PHASE2:Hg19::chrX:55246818..55246829,+#_02f5a7edccb66aacd08df30b8950b7b4 | p2@PAGE5 |
| 4.89e-23 | FFCP PHASE1:Hg19::chrX:55246818..55246829,+#_02f5a7edccb66aacd08df30b8950b7b4 | p2@PAGE5 |
| 3.11e-21 | FFCP PHASE2:Hg19::chr5:27742047..27742052,-#_23a75e50def3185ec34c6e75eda71a15 | p@chr5:27742047..27742052, - |
| 3.11e-21 | FFCP PHASE1:Hg19::chr5:27742047..27742052,-#_23a75e50def3185ec34c6e75eda71a15 | p@chr5:27742047..27742052, - |
| 3.11e-21 | FFCP PHASE2:Hg19::chr12:127737083..127737103,-#_23a75e50def3185ec34c6e75eda71a15 | p@chr12:127737083..127737103, - |
| 3.11e-21 | FFCP PHASE1:Hg19::chr12:127737083..127737103,-#_23a75e50def3185ec34c6e75eda71a15 | p@chr12:127737083..127737103, - |
| 3.11e-21 | FFCP PHASE2:Hg19::chr8:119905427..119905438,-#_23a75e50def3185ec34c6e75eda71a15 | p@chr8:119905427..119905438, - |
| 3.11e-21 | FFCP PHASE1:Hg19::chr8:119905427..119905438,-#_23a75e50def3185ec34c6e75eda71a15 | p@chr8:119905427..119905438, - |
| 3.81e-21 | FFCP PHASE2:Hg19::chr9:118595109..118595124,+#_71c506c94b939e7505d1010920c0a5cb | p@chr9:118595109..118595124, + |
| 3.81e-21 | FFCP PHASE1:Hg19::chr13:87732242..87732246,-#_71c506c94b939e7505d1010920c0a5cb | p@chr13:87732242..87732246, - |
| 3.81e-21 | FFCP PHASE1:Hg19::chr19:9811101..9811112,-#_71c506c94b939e7505d1010920c0a5cb | p3@ZNF812 |
| 3.81e-21 | FFCP PHASE1:Hg19::chr9:118595109..118595124,+#_71c506c94b939e7505d1010920c0a5cb | p@chr9:118595109..118595124, + |
| 3.81e-21 | FFCP PHASE2:Hg19::chr5:135378750..135378757,+#_71c506c94b939e7505d1010920c0a5cb | p@chr5:135378750..135378757, + |
| 3.81e-21 | FFCP PHASE1:Hg19::chr5:135378750..135378757,+#_71c506c94b939e7505d1010920c0a5cb | p@chr5:135378750..135378757, + |
| 3.81e-21 | FFCP PHASE2:Hg19::chr2:145815206..145815208,+#_71c506c94b939e7505d1010920c0a5cb | p@chr2:145815206..145815208, + |
| 3.81e-21 | FFCP PHASE1:Hg19::chr2:145815206..145815208,+#_71c506c94b939e7505d1010920c0a5cb | p@chr2:145815206..145815208, + |
| 3.81e-21 | FFCP PHASE2:Hg19::chr13:87732242..87732246,-#_71c506c94b939e7505d1010920c0a5cb | p@chr13:87732242..87732246, - |
| 3.81e-21 | FFCP PHASE2:Hg19::chr19:9811101..9811112,-#_71c506c94b939e7505d1010920c0a5cb | p3@ZNF812 |
| 4.66e-21 | FFCP PHASE2:Hg19::chrX:140336680..140336697,-#_9c0b0d452b1dad3af03606a959be177f | p2@SPANXC |
| 4.66e-21 | FFCP PHASE1:Hg19::chrX:140336680..140336697,-#_9c0b0d452b1dad3af03606a959be177f | p2@SPANXC |
| 5.7e-21 | FFCP PHASE1:Hg19::chr2:33171944..33171945,+#_8540f02e5c5ad9ca3af574841967f8a4 | p15@LTBP1 |
| 5.7e-21 | FFCP PHASE2:Hg19::chr5:142000787..142000807,-#_8540f02e5c5ad9ca3af574841967f8a4 | p@chr5:142000787..142000807, - |
| 5.7e-21 | FFCP PHASE1:Hg19::chr5:142000787..142000807,-#_8540f02e5c5ad9ca3af574841967f8a4 | p@chr5:142000787..142000807, - |
| 5.7e-21 | FFCP PHASE2:Hg19::chr2:33171944..33171945,+#_8540f02e5c5ad9ca3af574841967f8a4 | p15@LTBP1 |
| 6.96e-21 | FFCP PHASE1:Hg19::chr11:12061317..12061323,-#_9878b9d457bc8a70757269c025f120b6 | p@chr11:12061317..12061323, - |
| 6.96e-21 | FFCP PHASE1:Hg19::chr11:28792916..28792929,+#_9878b9d457bc8a70757269c025f120b6 | p@chr11:28792916..28792929, + |
| 6.96e-21 | FFCP PHASE2:Hg19::chr3:60761167..60761179,+#_9878b9d457bc8a70757269c025f120b6 | p@chr3:60761167..60761179, + |
| 6.96e-21 | FFCP PHASE2:Hg19::chr8:76774227..76774234,+#_9878b9d457bc8a70757269c025f120b6 | p@chr8:76774227..76774234, + |
| 6.96e-21 | FFCP PHASE1:Hg19::chr3:60761167..60761179,+#_9878b9d457bc8a70757269c025f120b6 | p@chr3:60761167..60761179, + |
| 6.96e-21 | FFCP PHASE1:Hg19::chr8:76774227..76774234,+#_9878b9d457bc8a70757269c025f120b6 | p@chr8:76774227..76774234, + |
| 6.96e-21 | FFCP PHASE2:Hg19::chr5:81611412..81611423,+#_9878b9d457bc8a70757269c025f120b6 | p@chr5:81611412..81611423, + |
| 6.96e-21 | FFCP PHASE2:Hg19::chr18:63273310..63273317,+#_9878b9d457bc8a70757269c025f120b6 | p@chr18:63273310..63273317, + |
| 6.96e-21 | FFCP PHASE2:Hg19::chr11:12061317..12061323,-#_9878b9d457bc8a70757269c025f120b6 | p@chr11:12061317..12061323, - |
| 6.96e-21 | FFCP PHASE1:Hg19::chr5:81611412..81611423,+#_9878b9d457bc8a70757269c025f120b6 | p@chr5:81611412..81611423, + |
| 6.96e-21 | FFCP PHASE2:Hg19::chr11:28792916..28792929,+#_9878b9d457bc8a70757269c025f120b6 | p@chr11:28792916..28792929, + |
| 6.96e-21 | FFCP PHASE1:Hg19::chr18:63273310..63273317,+#_9878b9d457bc8a70757269c025f120b6 | p@chr18:63273310..63273317, + |
