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CL:0000092

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Name:osteoclast
Namespace:FANTOM
Definition:"A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158]
Xrefs:
links:

BTO:0000968

FMA:66781
Synonyms: "chondroclast" RELATED []
Comments:Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.


Ontology association
Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.

link to ontology dataset
data


Parents

is_a:CL:0000766(myeloid leukocyte),CL:0001035(bone cell)
develops_from:CL:0000576(monocyte)
part_of:UBERON:0001474(bone element)



Children


derives from:FF:0100969 (osteoclastoma cell sample),FF:0200020 (osteoclast, bone marrow-derived sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples
It includes FANTOM5 samples that overlay the Cell ontology.


Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000092 (osteoclast), sorted by p-values
Analyst: Hideya Kawaji

link to source dataset
human : data
mouse : data


P-valueFFCPShort description
1.55e-98FFCP PHASE1:Hg19::chr16:77317713..77317723,+#_b903eca76d53485a4f1d302a80ba1931p1@CU687665
1.55e-98FFCP PHASE2:Hg19::chr11:101742272..101742276,-#_b903eca76d53485a4f1d302a80ba1931p@chr11:101742272..101742276, -
1.55e-98FFCP PHASE1:Hg19::chr11:101742272..101742276,-#_b903eca76d53485a4f1d302a80ba1931p@chr11:101742272..101742276, -
1.55e-98FFCP PHASE2:Hg19::chr16:77317713..77317723,+#_b903eca76d53485a4f1d302a80ba1931p1@CU687665
2.74e-50FFCP PHASE2:Hg19::chr11:81551043..81551054,-#_33220fce424e59c6ca585a69a9fb1376p@chr11:81551043..81551054, -
2.74e-50FFCP PHASE2:Hg19::chr18:71197490..71197495,-#_33220fce424e59c6ca585a69a9fb1376p@chr18:71197490..71197495, -
2.74e-50FFCP PHASE1:Hg19::chr16:51670868..51670880,-#_33220fce424e59c6ca585a69a9fb1376p@chr16:51670868..51670880, -
2.74e-50FFCP PHASE1:Hg19::chr5:14034644..14034647,-#_33220fce424e59c6ca585a69a9fb1376p@chr5:14034644..14034647, -
2.74e-50FFCP PHASE1:Hg19::chr11:81551043..81551054,-#_33220fce424e59c6ca585a69a9fb1376p@chr11:81551043..81551054, -
2.74e-50FFCP PHASE2:Hg19::chr16:51670868..51670880,-#_33220fce424e59c6ca585a69a9fb1376p@chr16:51670868..51670880, -
2.74e-50FFCP PHASE2:Hg19::chr5:14034644..14034647,-#_33220fce424e59c6ca585a69a9fb1376p@chr5:14034644..14034647, -
2.74e-50FFCP PHASE1:Hg19::chr18:71197490..71197495,-#_33220fce424e59c6ca585a69a9fb1376p@chr18:71197490..71197495, -
4.52e-50FFCP PHASE1:Hg19::chr4:34480309..34480321,-#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr4:34480309..34480321, -
4.52e-50FFCP PHASE2:Hg19::chr4:34480309..34480321,-#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr4:34480309..34480321, -
4.52e-50FFCP PHASE2:Hg19::chr5:23952305..23952310,+#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr5:23952305..23952310, +
4.52e-50FFCP PHASE2:Hg19::chr3:45174403..45174415,+#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr3:45174403..45174415, +
4.52e-50FFCP PHASE1:Hg19::chr3:106393655..106393659,+#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr3:106393655..106393659, +
4.52e-50FFCP PHASE2:Hg19::chr3:106393655..106393659,+#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr3:106393655..106393659, +
4.52e-50FFCP PHASE1:Hg19::chr3:45174403..45174415,+#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr3:45174403..45174415, +
4.52e-50FFCP PHASE1:Hg19::chr5:23952305..23952310,+#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr5:23952305..23952310, +
3.61e-34FFCP PHASE1:Hg19::chr7:119353807..119353812,-#_c06849cd5e3fae14cd7426a8305dd2a6p@chr7:119353807..119353812, -
3.61e-34FFCP PHASE2:Hg19::chr7:119353807..119353812,-#_c06849cd5e3fae14cd7426a8305dd2a6p@chr7:119353807..119353812, -
3.61e-34FFCP PHASE1:Hg19::chr4:177796841..177796851,+#_c06849cd5e3fae14cd7426a8305dd2a6p1@ENST00000508790
3.61e-34FFCP PHASE2:Hg19::chr4:177796841..177796851,+#_c06849cd5e3fae14cd7426a8305dd2a6p1@ENST00000508790
5.04e-34FFCP PHASE2:Hg19::chr10:37004821..37004852,-#_d8e3c1647d49dfbb2f4c17d1404d654fp@chr10:37004821..37004852, -
5.04e-34FFCP PHASE2:Hg19::chrX:132231123..132231140,-#_d8e3c1647d49dfbb2f4c17d1404d654fp1@USP26
5.04e-34FFCP PHASE1:Hg19::chr10:37004821..37004852,-#_d8e3c1647d49dfbb2f4c17d1404d654fp@chr10:37004821..37004852, -
5.04e-34FFCP PHASE2:Hg19::chr8:15939682..15939688,+#_d8e3c1647d49dfbb2f4c17d1404d654fp@chr8:15939682..15939688, +
5.04e-34FFCP PHASE1:Hg19::chr4:46093758..46093781,-#_d8e3c1647d49dfbb2f4c17d1404d654fp@chr4:46093758..46093781, -
5.04e-34FFCP PHASE1:Hg19::chr8:15939682..15939688,+#_d8e3c1647d49dfbb2f4c17d1404d654fp@chr8:15939682..15939688, +
5.04e-34FFCP PHASE2:Hg19::chr4:46093758..46093781,-#_d8e3c1647d49dfbb2f4c17d1404d654fp@chr4:46093758..46093781, -
5.04e-34FFCP PHASE1:Hg19::chrX:132231123..132231140,-#_d8e3c1647d49dfbb2f4c17d1404d654fp1@USP26
7.05e-34FFCP PHASE2:Hg19::chrX:89462083..89462089,+#_85c553399eb943d9f9d14fe1e1033c67p@chrX:89462083..89462089, +
7.05e-34FFCP PHASE1:Hg19::chr6:155427848..155427862,+#_85c553399eb943d9f9d14fe1e1033c67p@chr6:155427848..155427862, +
7.05e-34FFCP PHASE1:Hg19::chrX:89462083..89462089,+#_85c553399eb943d9f9d14fe1e1033c67p@chrX:89462083..89462089, +
7.05e-34FFCP PHASE2:Hg19::chr11:84019133..84019135,-#_85c553399eb943d9f9d14fe1e1033c67p@chr11:84019133..84019135, -
7.05e-34FFCP PHASE1:Hg19::chr11:84019133..84019135,-#_85c553399eb943d9f9d14fe1e1033c67p@chr11:84019133..84019135, -
7.05e-34FFCP PHASE2:Hg19::chr6:155427848..155427862,+#_85c553399eb943d9f9d14fe1e1033c67p@chr6:155427848..155427862, +
5.5e-31FFCP PHASE2:Hg19::chr3:106556598..106556609,-#_f68521af51a91f3238c0e54fb137aa1e-, p@chr3:106556598..106556609
5.5e-31FFCP PHASE1:Hg19::chr3:106556598..106556609,-#_f68521af51a91f3238c0e54fb137aa1ep@chr3:106556598..106556609, -
7.1e-28FFCP PHASE1:Hg19::chr6:68597008..68597030,-#_7e3f148977a24c49a4c7e2fb478f64d6p@chr6:68597008..68597030, -
7.1e-28FFCP PHASE2:Hg19::chr6:68597008..68597030,-#_7e3f148977a24c49a4c7e2fb478f64d6p@chr6:68597008..68597030, -
4.32e-26FFCP PHASE1:Hg19::chr11:81549961..81549965,-#_3d436b61f22464e3293afc5cb9600f13p@chr11:81549961..81549965, -
4.32e-26FFCP PHASE1:Hg19::chr5:27723923..27723927,-#_3d436b61f22464e3293afc5cb9600f13p@chr5:27723923..27723927, -
4.32e-26FFCP PHASE2:Hg19::chr5:27723923..27723927,-#_3d436b61f22464e3293afc5cb9600f13-, p@chr5:27723923..27723927
4.32e-26FFCP PHASE2:Hg19::chr11:81549961..81549965,-#_3d436b61f22464e3293afc5cb9600f13p@chr11:81549961..81549965, -
5.56e-26FFCP PHASE1:Hg19::chrX:89176902..89176913,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp1@TGIF2LX
5.56e-26FFCP PHASE1:Hg19::chrX:124347061..124347063,-#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chrX:124347061..124347063, -
5.56e-26FFCP PHASE1:Hg19::chr5:153673183..153673186,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chr5:153673183..153673186, +
5.56e-26FFCP PHASE1:Hg19::chrX:132352373..132352384,-#_fcf427a9031ef6a1f81ae8af91e0d2fdp1@TFDP3
5.56e-26FFCP PHASE1:Hg19::chr4:189864018..189864037,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chr4:189864018..189864037, +
5.56e-26FFCP PHASE2:Hg19::chrX:124347061..124347063,-#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chrX:124347061..124347063, -
5.56e-26FFCP PHASE2:Hg19::chrX:132352373..132352384,-#_fcf427a9031ef6a1f81ae8af91e0d2fdp1@TFDP3
5.56e-26FFCP PHASE2:Hg19::chr5:153673183..153673186,+#_fcf427a9031ef6a1f81ae8af91e0d2fd+, p@chr5:153673183..153673186
5.56e-26FFCP PHASE2:Hg19::chr4:189864018..189864037,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chr4:189864018..189864037, +
5.56e-26FFCP PHASE1:Hg19::chr5:167315847..167315852,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chr5:167315847..167315852, +
5.56e-26FFCP PHASE2:Hg19::chr5:167315847..167315852,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chr5:167315847..167315852, +
5.56e-26FFCP PHASE2:Hg19::chrX:89176902..89176913,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp1@TGIF2LX
9.18e-26FFCP PHASE1:Hg19::chr7:12997533..12997536,+#_49480e96743bab033845ce4266ec09a5p@chr7:12997533..12997536, +
9.18e-26FFCP PHASE2:Hg19::chr7:12997533..12997536,+#_49480e96743bab033845ce4266ec09a5p@chr7:12997533..12997536, +
9.18e-26FFCP PHASE1:Hg19::chr18:14946224..14946236,+#_49480e96743bab033845ce4266ec09a5p1@FLJ44255
9.18e-26FFCP PHASE2:Hg19::chr18:14946224..14946236,+#_49480e96743bab033845ce4266ec09a5p1@FLJ44255
1.12e-25FFCP PHASE1:Hg19::chrX:55246809..55246816,+#_254b010d2b257690dc483a55542712c5p3@PAGE5
1.12e-25FFCP PHASE2:Hg19::chrX:55246809..55246816,+#_254b010d2b257690dc483a55542712c5p3@PAGE5
4.89e-23FFCP PHASE1:Hg19::chrX:55246818..55246829,+#_02f5a7edccb66aacd08df30b8950b7b4p2@PAGE5
4.89e-23FFCP PHASE2:Hg19::chrX:55246818..55246829,+#_02f5a7edccb66aacd08df30b8950b7b4p2@PAGE5
3.11e-21FFCP PHASE2:Hg19::chr12:127737083..127737103,-#_23a75e50def3185ec34c6e75eda71a15p@chr12:127737083..127737103, -
3.11e-21FFCP PHASE1:Hg19::chr12:127737083..127737103,-#_23a75e50def3185ec34c6e75eda71a15p@chr12:127737083..127737103, -
3.11e-21FFCP PHASE1:Hg19::chr5:27742047..27742052,-#_23a75e50def3185ec34c6e75eda71a15p@chr5:27742047..27742052, -
3.11e-21FFCP PHASE2:Hg19::chr8:119905427..119905438,-#_23a75e50def3185ec34c6e75eda71a15p@chr8:119905427..119905438, -
3.11e-21FFCP PHASE1:Hg19::chr8:119905427..119905438,-#_23a75e50def3185ec34c6e75eda71a15p@chr8:119905427..119905438, -
3.11e-21FFCP PHASE2:Hg19::chr5:27742047..27742052,-#_23a75e50def3185ec34c6e75eda71a15p@chr5:27742047..27742052, -
3.81e-21FFCP PHASE1:Hg19::chr9:118595109..118595124,+#_71c506c94b939e7505d1010920c0a5cbp@chr9:118595109..118595124, +
3.81e-21FFCP PHASE2:Hg19::chr13:87732242..87732246,-#_71c506c94b939e7505d1010920c0a5cbp@chr13:87732242..87732246, -
3.81e-21FFCP PHASE2:Hg19::chr2:145815206..145815208,+#_71c506c94b939e7505d1010920c0a5cbp@chr2:145815206..145815208, +
3.81e-21FFCP PHASE2:Hg19::chr9:118595109..118595124,+#_71c506c94b939e7505d1010920c0a5cbp@chr9:118595109..118595124, +
3.81e-21FFCP PHASE2:Hg19::chr19:9811101..9811112,-#_71c506c94b939e7505d1010920c0a5cbp3@ZNF812
3.81e-21FFCP PHASE1:Hg19::chr5:135378750..135378757,+#_71c506c94b939e7505d1010920c0a5cbp@chr5:135378750..135378757, +
3.81e-21FFCP PHASE1:Hg19::chr13:87732242..87732246,-#_71c506c94b939e7505d1010920c0a5cbp@chr13:87732242..87732246, -
3.81e-21FFCP PHASE1:Hg19::chr2:145815206..145815208,+#_71c506c94b939e7505d1010920c0a5cbp@chr2:145815206..145815208, +
3.81e-21FFCP PHASE1:Hg19::chr19:9811101..9811112,-#_71c506c94b939e7505d1010920c0a5cbp3@ZNF812
3.81e-21FFCP PHASE2:Hg19::chr5:135378750..135378757,+#_71c506c94b939e7505d1010920c0a5cbp@chr5:135378750..135378757, +
4.66e-21FFCP PHASE1:Hg19::chrX:140336680..140336697,-#_9c0b0d452b1dad3af03606a959be177fp2@SPANXC
4.66e-21FFCP PHASE2:Hg19::chrX:140336680..140336697,-#_9c0b0d452b1dad3af03606a959be177fp2@SPANXC
5.7e-21FFCP PHASE2:Hg19::chr2:33171944..33171945,+#_8540f02e5c5ad9ca3af574841967f8a4p15@LTBP1
5.7e-21FFCP PHASE1:Hg19::chr2:33171944..33171945,+#_8540f02e5c5ad9ca3af574841967f8a4p15@LTBP1
5.7e-21FFCP PHASE1:Hg19::chr5:142000787..142000807,-#_8540f02e5c5ad9ca3af574841967f8a4p@chr5:142000787..142000807, -
5.7e-21FFCP PHASE2:Hg19::chr5:142000787..142000807,-#_8540f02e5c5ad9ca3af574841967f8a4p@chr5:142000787..142000807, -
6.96e-21FFCP PHASE1:Hg19::chr5:81611412..81611423,+#_9878b9d457bc8a70757269c025f120b6p@chr5:81611412..81611423, +
6.96e-21FFCP PHASE2:Hg19::chr8:76774227..76774234,+#_9878b9d457bc8a70757269c025f120b6+, p@chr8:76774227..76774234
6.96e-21FFCP PHASE1:Hg19::chr8:76774227..76774234,+#_9878b9d457bc8a70757269c025f120b6p@chr8:76774227..76774234, +
6.96e-21FFCP PHASE2:Hg19::chr5:81611412..81611423,+#_9878b9d457bc8a70757269c025f120b6p@chr5:81611412..81611423, +
6.96e-21FFCP PHASE2:Hg19::chr3:60761167..60761179,+#_9878b9d457bc8a70757269c025f120b6p@chr3:60761167..60761179, +
6.96e-21FFCP PHASE2:Hg19::chr11:12061317..12061323,-#_9878b9d457bc8a70757269c025f120b6p@chr11:12061317..12061323, -
6.96e-21FFCP PHASE2:Hg19::chr11:28792916..28792929,+#_9878b9d457bc8a70757269c025f120b6p@chr11:28792916..28792929, +
6.96e-21FFCP PHASE1:Hg19::chr18:63273310..63273317,+#_9878b9d457bc8a70757269c025f120b6p@chr18:63273310..63273317, +
6.96e-21FFCP PHASE1:Hg19::chr3:60761167..60761179,+#_9878b9d457bc8a70757269c025f120b6p@chr3:60761167..60761179, +
6.96e-21FFCP PHASE1:Hg19::chr11:12061317..12061323,-#_9878b9d457bc8a70757269c025f120b6p@chr11:12061317..12061323, -
6.96e-21FFCP PHASE2:Hg19::chr18:63273310..63273317,+#_9878b9d457bc8a70757269c025f120b6p@chr18:63273310..63273317, +
6.96e-21FFCP PHASE1:Hg19::chr11:28792916..28792929,+#_9878b9d457bc8a70757269c025f120b6p@chr11:28792916..28792929, +