CL:0000097
From FANTOM5_SSTAR
Name: | mast cell | ||
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Namespace: | FANTOM | ||
Definition: | "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:A.11.329.427, MESH:D008407, PMCID:PMC1312421, PMCID:PMC2855166, PMID:15153310, PMID:16455980, PMID:19671378, PMID:212366338, PMID:9354811] | ||
Xrefs: |
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Synonyms: |
"histaminocyte" EXACT [] "labrocyte" EXACT [ISBN:0721601464] "mastocyte" EXACT [ISBN:0721601464] "tissue basophil" RELATED [ISBN:068340007X] | ||
Comments: | Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
is_a: | CL:0000766(myeloid leukocyte),CL:0002274(histamine secreting cell) |
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develops_from: | CL:0000831(mast cell progenitor) |
Children
derives from: | FF:0000260 (mast cell sample) |
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Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 11486-119E1
- 11487-119E2 (Mast cell - stimulated, donor1)
- 11563-120D6 (Mast cell, donor1)
- 11564-120D7
- 11565-120D8 (Mast cell, donor2)
- 11566-120D9 (Mast cell, donor3)
- 11567-120E1 (Mast cell, donor4)
- 11939-126A4 (Mast cell, expanded, donor5)
- 11940-126A5 (Mast cell, expanded and stimulated, donor5)
- 11941-126A6 (Mast cell, expanded, donor8)
... further results Mouse (Mus musculus)
- 11486-119E1
- 11487-119E2 (Mast cell - stimulated, donor1)
- 11563-120D6 (Mast cell, donor1)
- 11564-120D7
- 11565-120D8 (Mast cell, donor2)
- 11566-120D9 (Mast cell, donor3)
- 11567-120E1 (Mast cell, donor4)
- 11939-126A4 (Mast cell, expanded, donor5)
- 11940-126A5 (Mast cell, expanded and stimulated, donor5)
- 11941-126A6 (Mast cell, expanded, donor8)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000097 (mast cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
P-value | FFCP | Short description |
---|---|---|
2.45e-195 | FFCP PHASE1:Hg19::chr6:23456883..23456894,+#_c72160135251738249757a8bab1f5009 | p@chr6:23456883..23456894, + |
2.45e-195 | FFCP PHASE1:Hg19::chr6:57326117..57326124,+#_c72160135251738249757a8bab1f5009 | p@chr6:57326117..57326124, + |
2.45e-195 | FFCP PHASE2:Hg19::chr11:59855794..59855805,+#_c72160135251738249757a8bab1f5009 | p5@MS4A2 |
2.45e-195 | FFCP PHASE2:Hg19::chr11:123985831..123985858,+#_c72160135251738249757a8bab1f5009 | p2@VWA5A |
2.45e-195 | FFCP PHASE2:Hg19::chr3:14425446..14425450,+#_c72160135251738249757a8bab1f5009 | p@chr3:14425446..14425450, + |
2.45e-195 | FFCP PHASE1:Hg19::chr14:25464405..25464415,-#_c72160135251738249757a8bab1f5009 | p@chr14:25464405..25464415, - |
2.45e-195 | FFCP PHASE2:Hg19::chr10:131653288..131653294,-#_c72160135251738249757a8bab1f5009 | p@chr10:131653288..131653294, - |
2.45e-195 | FFCP PHASE1:Hg19::chr9:116457979..116457994,+#_c72160135251738249757a8bab1f5009 | p@chr9:116457979..116457994, + |
2.45e-195 | FFCP PHASE2:Hg19::chrX:100617644..100617655,-#_c72160135251738249757a8bab1f5009 | p5@BTK |
2.45e-195 | FFCP PHASE1:Hg19::chr11:123967181..123967213,-#_c72160135251738249757a8bab1f5009 | p@chr11:123967181..123967213, - |
2.45e-195 | FFCP PHASE2:Hg19::chr14:24974148..24974156,+#_c72160135251738249757a8bab1f5009 | p@chr14:24974148..24974156, + |
2.45e-195 | FFCP PHASE1:Hg19::chr19:52034316..52034326,-#_c72160135251738249757a8bab1f5009 | p@chr19:52034316..52034326, - |
2.45e-195 | FFCP PHASE1:Hg19::chr6:16388683..16388699,-#_c72160135251738249757a8bab1f5009 | p@chr6:16388683..16388699, - |
2.45e-195 | FFCP PHASE1:Hg19::chr4:79698211..79698260,+#_c72160135251738249757a8bab1f5009 | p@chr4:79698211..79698260, + |
2.45e-195 | FFCP PHASE2:Hg19::chr6:57326117..57326124,+#_c72160135251738249757a8bab1f5009 | p@chr6:57326117..57326124, + |
2.45e-195 | FFCP PHASE2:Hg19::chr4:55523948..55523989,+#_c72160135251738249757a8bab1f5009 | p3@KIT |
2.45e-195 | FFCP PHASE1:Hg19::chr3:148583254..148583275,+#_c72160135251738249757a8bab1f5009 | p@chr3:148583254..148583275, + |
2.45e-195 | FFCP PHASE2:Hg19::chr19:56673816..56673830,-#_c72160135251738249757a8bab1f5009 | p@chr19:56673816..56673830, - |
2.45e-195 | FFCP PHASE1:Hg19::chr8:81214082..81214083,+#_c72160135251738249757a8bab1f5009 | p@chr8:81214082..81214083, + |
2.45e-195 | FFCP PHASE2:Hg19::chr11:59857223..59857242,+#_c72160135251738249757a8bab1f5009 | p@chr11:59857223..59857242, + |
2.45e-195 | FFCP PHASE2:Hg19::chr11:123988337..123988344,+#_c72160135251738249757a8bab1f5009 | p@chr11:123988337..123988344, + |
2.45e-195 | FFCP PHASE2:Hg19::chr16:1280084..1280116,-#_c72160135251738249757a8bab1f5009 | p2@TPSB2 |
2.45e-195 | FFCP PHASE2:Hg19::chr1:203732858..203732876,-#_c72160135251738249757a8bab1f5009 | p@chr1:203732858..203732876, - |
2.45e-195 | FFCP PHASE1:Hg19::chr4:55406116..55406147,+#_c72160135251738249757a8bab1f5009 | p@chr4:55406116..55406147, + |
2.45e-195 | FFCP PHASE1:Hg19::chr4:95261065..95261071,+#_c72160135251738249757a8bab1f5009 | p@chr4:95261065..95261071, + |
2.45e-195 | FFCP PHASE2:Hg19::chrX:29959760..29959772,+#_c72160135251738249757a8bab1f5009 | p@chrX:29959760..29959772, + |
2.45e-195 | FFCP PHASE1:Hg19::chr5:108071789..108071807,+#_c72160135251738249757a8bab1f5009 | p@chr5:108071789..108071807, + |
2.45e-195 | FFCP PHASE2:Hg19::chr5:108071574..108071598,-#_c72160135251738249757a8bab1f5009 | p@chr5:108071574..108071598, - |
2.45e-195 | FFCP PHASE2:Hg19::chr8:81214082..81214083,+#_c72160135251738249757a8bab1f5009 | p@chr8:81214082..81214083, + |
2.45e-195 | FFCP PHASE1:Hg19::chr7:138317555..138317567,-#_c72160135251738249757a8bab1f5009 | p@chr7:138317555..138317567, - |
2.45e-195 | FFCP PHASE1:Hg19::chr16:1280084..1280116,-#_c72160135251738249757a8bab1f5009 | p2@TPSB2 |
2.45e-195 | FFCP PHASE1:Hg19::chr3:148601435..148601446,+#_c72160135251738249757a8bab1f5009 | p@chr3:148601435..148601446, + |
2.45e-195 | FFCP PHASE2:Hg19::chr13:109328158..109328167,+#_c72160135251738249757a8bab1f5009 | p@chr13:109328158..109328167, + |
2.45e-195 | FFCP PHASE2:Hg19::chr11:47175922..47175952,+#_c72160135251738249757a8bab1f5009 | p3@C11orf49 |
2.45e-195 | FFCP PHASE1:Hg19::chr19:7923338..7923341,-#_c72160135251738249757a8bab1f5009 | p@chr19:7923338..7923341, - |
2.45e-195 | FFCP PHASE1:Hg19::chr2:160085237..160085246,+#_c72160135251738249757a8bab1f5009 | p@chr2:160085237..160085246, + |
2.45e-195 | FFCP PHASE1:Hg19::chr19:56673770..56673786,-#_c72160135251738249757a8bab1f5009 | p@chr19:56673770..56673786, - |
2.45e-195 | FFCP PHASE1:Hg19::chr11:59855794..59855805,+#_c72160135251738249757a8bab1f5009 | p5@MS4A2 |
2.45e-195 | FFCP PHASE1:Hg19::chr11:123985831..123985858,+#_c72160135251738249757a8bab1f5009 | p2@VWA5A |
2.45e-195 | FFCP PHASE2:Hg19::chr7:138317555..138317567,-#_c72160135251738249757a8bab1f5009 | p@chr7:138317555..138317567, - |
2.45e-195 | FFCP PHASE2:Hg19::chr6:16547983..16547995,-#_c72160135251738249757a8bab1f5009 | p@chr6:16547983..16547995, - |
2.45e-195 | FFCP PHASE1:Hg19::chr19:51961061..51961069,-#_c72160135251738249757a8bab1f5009 | p@chr19:51961061..51961069, - |
2.45e-195 | FFCP PHASE1:Hg19::chr15:69612281..69612294,-#_c72160135251738249757a8bab1f5009 | p@chr15:69612281..69612294, - |
2.45e-195 | FFCP PHASE1:Hg19::chr14:24042158..24042170,-#_c72160135251738249757a8bab1f5009 | p18@JPH4 |
2.45e-195 | FFCP PHASE2:Hg19::chr2:160085237..160085246,+#_c72160135251738249757a8bab1f5009 | p@chr2:160085237..160085246, + |
2.45e-195 | FFCP PHASE2:Hg19::chr1:204074045..204074052,+#_c72160135251738249757a8bab1f5009 | p@chr1:204074045..204074052, + |
2.45e-195 | FFCP PHASE2:Hg19::chr14:25464405..25464415,-#_c72160135251738249757a8bab1f5009 | p@chr14:25464405..25464415, - |
2.45e-195 | FFCP PHASE1:Hg19::chr1:20513747..20513758,-#_c72160135251738249757a8bab1f5009 | p@chr1:20513747..20513758, - |
2.45e-195 | FFCP PHASE1:Hg19::chr11:59857223..59857242,+#_c72160135251738249757a8bab1f5009 | p@chr11:59857223..59857242, + |
2.45e-195 | FFCP PHASE1:Hg19::chr11:123988337..123988344,+#_c72160135251738249757a8bab1f5009 | p@chr11:123988337..123988344, + |
2.45e-195 | FFCP PHASE2:Hg19::chr7:106372888..106372891,-#_c72160135251738249757a8bab1f5009 | p5@ENST00000490856 |
2.45e-195 | FFCP PHASE1:Hg19::chr1:247737511..247737525,+#_c72160135251738249757a8bab1f5009 | p@chr1:247737511..247737525, + |
2.45e-195 | FFCP PHASE1:Hg19::chr4:80665456..80665463,-#_c72160135251738249757a8bab1f5009 | p@chr4:80665456..80665463, - |
2.45e-195 | FFCP PHASE1:Hg19::chr4:175501777..175501788,-#_c72160135251738249757a8bab1f5009 | p@chr4:175501777..175501788, - |
2.45e-195 | FFCP PHASE2:Hg19::chr6:23456883..23456894,+#_c72160135251738249757a8bab1f5009 | p@chr6:23456883..23456894, + |
2.45e-195 | FFCP PHASE1:Hg19::chr19:52033117..52033128,-#_c72160135251738249757a8bab1f5009 | p@chr19:52033117..52033128, - |
2.45e-195 | FFCP PHASE1:Hg19::chr15:42221779..42221787,+#_c72160135251738249757a8bab1f5009 | p@chr15:42221779..42221787, + |
2.45e-195 | FFCP PHASE1:Hg19::chr15:50556017..50556029,-#_c72160135251738249757a8bab1f5009 | p3@HDC |
2.45e-195 | FFCP PHASE1:Hg19::chr2:12466225..12466247,+#_c72160135251738249757a8bab1f5009 | p@chr2:12466225..12466247, + |
2.45e-195 | FFCP PHASE1:Hg19::chr9:75770556..75770567,+#_c72160135251738249757a8bab1f5009 | p@chr9:75770556..75770567, + |
2.45e-195 | FFCP PHASE2:Hg19::chr11:123986842..123986855,+#_c72160135251738249757a8bab1f5009 | p@chr11:123986842..123986855, + |
2.45e-195 | FFCP PHASE1:Hg19::chr11:47175922..47175952,+#_c72160135251738249757a8bab1f5009 | p3@C11orf49 |
2.45e-195 | FFCP PHASE1:Hg19::chrX:29959742..29959751,+#_c72160135251738249757a8bab1f5009 | p@chrX:29959742..29959751, + |
2.45e-195 | FFCP PHASE1:Hg19::chr1:194021388..194021407,+#_c72160135251738249757a8bab1f5009 | p@chr1:194021388..194021407, + |
2.45e-195 | FFCP PHASE1:Hg19::chr7:106372888..106372891,-#_c72160135251738249757a8bab1f5009 | p5@ENST00000490856 |
2.45e-195 | FFCP PHASE2:Hg19::chr9:116457979..116457994,+#_c72160135251738249757a8bab1f5009 | p@chr9:116457979..116457994, + |
2.45e-195 | FFCP PHASE1:Hg19::chr6:16388717..16388738,-#_c72160135251738249757a8bab1f5009 | p@chr6:16388717..16388738, - |
2.45e-195 | FFCP PHASE2:Hg19::chr19:52034316..52034326,-#_c72160135251738249757a8bab1f5009 | p@chr19:52034316..52034326, - |
2.45e-195 | FFCP PHASE2:Hg19::chr6:16388683..16388699,-#_c72160135251738249757a8bab1f5009 | p@chr6:16388683..16388699, - |
2.45e-195 | FFCP PHASE2:Hg19::chr4:79698211..79698260,+#_c72160135251738249757a8bab1f5009 | p@chr4:79698211..79698260, + |
2.45e-195 | FFCP PHASE2:Hg19::chr2:12466225..12466247,+#_c72160135251738249757a8bab1f5009 | p@chr2:12466225..12466247, + |
2.45e-195 | FFCP PHASE1:Hg19::chr2:102922332..102922360,+#_c72160135251738249757a8bab1f5009 | p@chr2:102922332..102922360, + |
2.45e-195 | FFCP PHASE1:Hg19::chr10:131653288..131653294,-#_c72160135251738249757a8bab1f5009 | p@chr10:131653288..131653294, - |
2.45e-195 | FFCP PHASE2:Hg19::chr3:148583254..148583275,+#_c72160135251738249757a8bab1f5009 | p@chr3:148583254..148583275, + |
2.45e-195 | FFCP PHASE2:Hg19::chr4:55406116..55406147,+#_c72160135251738249757a8bab1f5009 | p@chr4:55406116..55406147, + |
2.45e-195 | FFCP PHASE2:Hg19::chr2:102922332..102922360,+#_c72160135251738249757a8bab1f5009 | p@chr2:102922332..102922360, + |
2.45e-195 | FFCP PHASE1:Hg19::chr3:14425446..14425450,+#_c72160135251738249757a8bab1f5009 | p@chr3:14425446..14425450, + |
2.45e-195 | FFCP PHASE2:Hg19::chr4:95261065..95261071,+#_c72160135251738249757a8bab1f5009 | p@chr4:95261065..95261071, + |
2.45e-195 | FFCP PHASE1:Hg19::chr2:160085182..160085196,+#_c72160135251738249757a8bab1f5009 | p@chr2:160085182..160085196, + |
2.45e-195 | FFCP PHASE2:Hg19::chr7:106372896..106372907,-#_c72160135251738249757a8bab1f5009 | p3@ENST00000490856 |
2.45e-195 | FFCP PHASE2:Hg19::chr15:69612281..69612294,-#_c72160135251738249757a8bab1f5009 | p@chr15:69612281..69612294, - |
2.45e-195 | FFCP PHASE2:Hg19::chr5:108071789..108071807,+#_c72160135251738249757a8bab1f5009 | p@chr5:108071789..108071807, + |
2.45e-195 | FFCP PHASE2:Hg19::chr14:24042158..24042170,-#_c72160135251738249757a8bab1f5009 | p18@JPH4 |
2.45e-195 | FFCP PHASE1:Hg19::chrX:100617644..100617655,-#_c72160135251738249757a8bab1f5009 | p5@BTK |
2.45e-195 | FFCP PHASE2:Hg19::chr3:148601435..148601446,+#_c72160135251738249757a8bab1f5009 | p@chr3:148601435..148601446, + |
2.45e-195 | FFCP PHASE1:Hg19::chr14:54899928..54899942,-#_c72160135251738249757a8bab1f5009 | p@chr14:54899928..54899942, - |
2.45e-195 | FFCP PHASE2:Hg19::chr2:160085182..160085196,+#_c72160135251738249757a8bab1f5009 | p@chr2:160085182..160085196, + |
2.45e-195 | FFCP PHASE2:Hg19::chr19:56673770..56673786,-#_c72160135251738249757a8bab1f5009 | p@chr19:56673770..56673786, - |
2.45e-195 | FFCP PHASE1:Hg19::chr4:55523948..55523989,+#_c72160135251738249757a8bab1f5009 | p3@KIT |
2.45e-195 | FFCP PHASE2:Hg19::chr19:7923338..7923341,-#_c72160135251738249757a8bab1f5009 | p@chr19:7923338..7923341, - |
2.45e-195 | FFCP PHASE1:Hg19::chr19:56673816..56673830,-#_c72160135251738249757a8bab1f5009 | p@chr19:56673816..56673830, - |
2.45e-195 | FFCP PHASE1:Hg19::chrX:29959760..29959772,+#_c72160135251738249757a8bab1f5009 | p@chrX:29959760..29959772, + |
2.45e-195 | FFCP PHASE2:Hg19::chr19:51961061..51961069,-#_c72160135251738249757a8bab1f5009 | p@chr19:51961061..51961069, - |
2.45e-195 | FFCP PHASE1:Hg19::chr11:123986842..123986855,+#_c72160135251738249757a8bab1f5009 | p@chr11:123986842..123986855, + |
2.45e-195 | FFCP PHASE1:Hg19::chr1:203732858..203732876,-#_c72160135251738249757a8bab1f5009 | p@chr1:203732858..203732876, - |
2.45e-195 | FFCP PHASE1:Hg19::chr7:106372896..106372907,-#_c72160135251738249757a8bab1f5009 | p3@ENST00000490856 |
2.45e-195 | FFCP PHASE1:Hg19::chr5:108071574..108071598,-#_c72160135251738249757a8bab1f5009 | p@chr5:108071574..108071598, - |
2.45e-195 | FFCP PHASE1:Hg19::chr14:24974148..24974156,+#_c72160135251738249757a8bab1f5009 | p@chr14:24974148..24974156, + |
2.45e-195 | FFCP PHASE2:Hg19::chr15:42221779..42221787,+#_c72160135251738249757a8bab1f5009 | p@chr15:42221779..42221787, + |
2.45e-195 | FFCP PHASE2:Hg19::chr15:50556017..50556029,-#_c72160135251738249757a8bab1f5009 | p3@HDC |