MCL coexpression mm9:1258
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005681 | spliceosome | 5.61954294543226e-06 |
| GO:0008380 | RNA splicing | 6.66597430610392e-06 |
| GO:0006397 | mRNA processing | 1.23376633643291e-05 |
| GO:0016071 | mRNA metabolic process | 1.45117378951032e-05 |
| GO:0006396 | RNA processing | 4.03625053793264e-05 |
| GO:0044428 | nuclear part | 4.39995964132779e-05 |
| GO:0030529 | ribonucleoprotein complex | 6.67731415176424e-05 |
| GO:0030532 | small nuclear ribonucleoprotein complex | 6.67731415176424e-05 |
| GO:0003723 | RNA binding | 0.000124435294817082 |
| GO:0000375 | RNA splicing, via transesterification reactions | 0.000649988483381811 |
| GO:0000398 | nuclear mRNA splicing, via spliceosome | 0.000649988483381811 |
| GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 0.000649988483381811 |
| GO:0032991 | macromolecular complex | 0.000649988483381811 |
| GO:0005634 | nucleus | 0.000769721621827877 |
| GO:0044446 | intracellular organelle part | 0.00113519242690883 |
| GO:0044422 | organelle part | 0.00113519242690883 |
| GO:0030629 | U6 snRNA 3'-end binding | 0.00208829491364836 |
| GO:0017070 | U6 snRNA binding | 0.00394401676804148 |
| GO:0006374 | nuclear mRNA splicing via U2-type spliceosome | 0.00560388773734823 |
| GO:0043231 | intracellular membrane-bound organelle | 0.00739199319082538 |
| GO:0043227 | membrane-bound organelle | 0.00739199319082538 |
| GO:0004839 | ubiquitin activating enzyme activity | 0.00739199319082538 |
| GO:0017069 | snRNA binding | 0.00739199319082538 |
| GO:0046540 | U4/U6 x U5 tri-snRNP complex | 0.00739199319082538 |
| GO:0008641 | small protein activating enzyme activity | 0.0106270574167507 |
| GO:0043283 | biopolymer metabolic process | 0.0106270574167507 |
| GO:0016070 | RNA metabolic process | 0.0106270574167507 |
| GO:0008180 | signalosome | 0.0113985425775183 |
| GO:0043229 | intracellular organelle | 0.0117543994217399 |
| GO:0043226 | organelle | 0.0117543994217399 |
| GO:0008022 | protein C-terminus binding | 0.0148630715030053 |
| GO:0005732 | small nucleolar ribonucleoprotein complex | 0.0166092194431962 |
| GO:0010467 | gene expression | 0.0166720700225567 |
| GO:0000184 | mRNA catabolic process, nonsense-mediated decay | 0.0166720700225567 |
| GO:0003676 | nucleic acid binding | 0.0176196444999963 |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0226282907447422 |
| GO:0006402 | mRNA catabolic process | 0.0265999237757644 |
| GO:0043170 | macromolecule metabolic process | 0.0265999237757644 |
| GO:0044424 | intracellular part | 0.0265999237757644 |
| GO:0006401 | RNA catabolic process | 0.0282804818424051 |
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | 0.0289124408135589 |
| GO:0016859 | cis-trans isomerase activity | 0.0289124408135589 |
| GO:0044452 | nucleolar part | 0.0289124408135589 |
| GO:0005622 | intracellular | 0.0289124408135589 |
| GO:0016567 | protein ubiquitination | 0.0298271027999113 |
| GO:0032446 | protein modification by small protein conjugation | 0.0345206046749659 |
| GO:0016072 | rRNA metabolic process | 0.0389208784610221 |
| GO:0006364 | rRNA processing | 0.0389208784610221 |
| GO:0044238 | primary metabolic process | 0.0410485133826842 |
| GO:0044237 | cellular metabolic process | 0.0410485133826842 |
| GO:0046982 | protein heterodimerization activity | 0.0414298020721974 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br><br><br>
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.476238 |
| MA0004.1 | 1.3269 |
| MA0006.1 | 0.359699 |
| MA0007.1 | 0.52077 |
| MA0009.1 | 0.987341 |
| MA0014.1 | 0.558098 |
| MA0017.1 | 0.387481 |
| MA0019.1 | 0.800946 |
| MA0024.1 | 0.942716 |
| MA0025.1 | 1.22395 |
| MA0027.1 | 2.64231 |
| MA0028.1 | 0.969171 |
| MA0029.1 | 0.920529 |
| MA0030.1 | 0.927235 |
| MA0031.1 | 0.890871 |
| MA0038.1 | 0.686534 |
| MA0040.1 | 1.00009 |
| MA0041.1 | 0.457338 |
| MA0042.1 | 0.443591 |
| MA0043.1 | 1.08567 |
| MA0046.1 | 1.02391 |
| MA0048.1 | 0.486223 |
| MA0050.1 | 0.57678 |
| MA0051.1 | 0.695779 |
| MA0052.1 | 1.00829 |
| MA0055.1 | 0.0585191 |
| MA0056.1 | 0 |
| MA0057.1 | 0.149949 |
| MA0058.1 | 1.11298 |
| MA0059.1 | 1.99202 |
| MA0060.1 | 0.757042 |
| MA0061.1 | 0.307097 |
| MA0063.1 | 0 |
| MA0066.1 | 1.61836 |
| MA0067.1 | 1.33603 |
| MA0068.1 | 0.467569 |
| MA0069.1 | 1.00864 |
| MA0070.1 | 0.998765 |
| MA0071.1 | 0.575909 |
| MA0072.1 | 0.990133 |
| MA0073.1 | 0.000157319 |
| MA0074.1 | 0.638014 |
| MA0076.1 | 1.85013 |
| MA0077.1 | 0.968053 |
| MA0078.1 | 0.729877 |
| MA0081.1 | 0.473489 |
| MA0083.1 | 1.08487 |
| MA0084.1 | 1.66561 |
| MA0087.1 | 1.04109 |
| MA0088.1 | 0.111145 |
| MA0089.1 | 0 |
| MA0090.1 | 0.500693 |
| MA0091.1 | 0.55008 |
| MA0092.1 | 0.501022 |
| MA0093.1 | 1.75322 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.626021 |
| MA0101.1 | 0.458688 |
| MA0103.1 | 0.398766 |
| MA0105.1 | 0.199622 |
| MA0106.1 | 0.737893 |
| MA0107.1 | 0.392331 |
| MA0108.2 | 0.824407 |
| MA0109.1 | 0 |
| MA0111.1 | 0.515457 |
| MA0113.1 | 0.708789 |
| MA0114.1 | 0.822296 |
| MA0115.1 | 1.08851 |
| MA0116.1 | 0.359483 |
| MA0117.1 | 1.05576 |
| MA0119.1 | 0.459301 |
| MA0122.1 | 1.07591 |
| MA0124.1 | 1.28237 |
| MA0125.1 | 1.20757 |
| MA0130.1 | 0 |
| MA0131.1 | 0.796279 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.1226 |
| MA0136.1 | 0.658622 |
| MA0139.1 | 0.682297 |
| MA0140.1 | 0.625902 |
| MA0141.1 | 1.07584 |
| MA0142.1 | 0.876028 |
| MA0143.1 | 0.725672 |
| MA0144.1 | 0.307873 |
| MA0145.1 | 0.379391 |
| MA0146.1 | 0.635245 |
| MA0147.1 | 0.858298 |
| MA0148.1 | 0.553294 |
| MA0149.1 | 0.464445 |
| MA0062.2 | 4.14052 |
| MA0035.2 | 0.630778 |
| MA0039.2 | 0.769467 |
| MA0138.2 | 0.788113 |
| MA0002.2 | 0.246463 |
| MA0137.2 | 0.416331 |
| MA0104.2 | 0.723439 |
| MA0047.2 | 0.685741 |
| MA0112.2 | 0.37938 |
| MA0065.2 | 0.380324 |
| MA0150.1 | 0.520653 |
| MA0151.1 | 0 |
| MA0152.1 | 0.685852 |
| MA0153.1 | 1.13945 |
| MA0154.1 | 0.159217 |
| MA0155.1 | 0.414701 |
| MA0156.1 | 0.406559 |
| MA0157.1 | 0.843181 |
| MA0158.1 | 0 |
| MA0159.1 | 0.331229 |
| MA0160.1 | 0.556423 |
| MA0161.1 | 0 |
| MA0162.1 | 0.70356 |
| MA0163.1 | 0.0423021 |
| MA0164.1 | 0.658997 |
| MA0080.2 | 0.393257 |
| MA0018.2 | 0.669032 |
| MA0099.2 | 0.781628 |
| MA0079.2 | 0.0912348 |
| MA0102.2 | 1.7182 |
| MA0258.1 | 0.290587 |
| MA0259.1 | 0.833237 |
| MA0442.1 | 0 |
