MCL coexpression mm9:1304
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0015184 | L-cystine transmembrane transporter activity | 0.00467503058857905 |
| GO:0000101 | sulfur amino acid transport | 0.00467503058857905 |
| GO:0051125 | regulation of actin nucleation | 0.00467503058857905 |
| GO:0000099 | sulfur amino acid transmembrane transporter activity | 0.00467503058857905 |
| GO:0015811 | L-cystine transport | 0.00467503058857905 |
| GO:0051127 | positive regulation of actin nucleation | 0.00467503058857905 |
| GO:0008900 | hydrogen:potassium-exchanging ATPase activity | 0.00801367951130475 |
| GO:0030838 | positive regulation of actin filament polymerization | 0.00934852440535652 |
| GO:0045010 | actin nucleation | 0.00934852440535652 |
| GO:0051130 | positive regulation of cellular component organization and biogenesis | 0.016823195403582 |
| GO:0015807 | L-amino acid transport | 0.023357868680412 |
| GO:0030833 | regulation of actin filament polymerization | 0.023357868680412 |
| GO:0030041 | actin filament polymerization | 0.0366328029020975 |
| GO:0015179 | L-amino acid transmembrane transporter activity | 0.0459991902383788 |
| GO:0008064 | regulation of actin polymerization and/or depolymerization | 0.0460173561850889 |
| GO:0032535 | regulation of cellular component size | 0.0460173561850889 |
| GO:0032956 | regulation of actin cytoskeleton organization and biogenesis | 0.0460173561850889 |
| GO:0030832 | regulation of actin filament length | 0.0460173561850889 |
| GO:0051493 | regulation of cytoskeleton organization and biogenesis | 0.0460173561850889 |
| GO:0033043 | regulation of organelle organization and biogenesis | 0.0460173561850889 |
| GO:0015171 | amino acid transmembrane transporter activity | 0.0460173561850889 |
| GO:0051258 | protein polymerization | 0.0460173561850889 |
| GO:0022891 | substrate-specific transmembrane transporter activity | 0.0460173561850889 |
| GO:0008154 | actin polymerization and/or depolymerization | 0.0460173561850889 |
| GO:0006865 | amino acid transport | 0.0460173561850889 |
| GO:0015837 | amine transport | 0.0460173561850889 |
| GO:0015992 | proton transport | 0.0460173561850889 |
| GO:0022857 | transmembrane transporter activity | 0.0460173561850889 |
| GO:0051128 | regulation of cellular component organization and biogenesis | 0.0460173561850889 |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 0.0460173561850889 |
| GO:0006818 | hydrogen transport | 0.0460173561850889 |
| GO:0005342 | organic acid transmembrane transporter activity | 0.0460173561850889 |
| GO:0044425 | membrane part | 0.0460173561850889 |
| GO:0015662 | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | 0.0460173561850889 |
| GO:0046942 | carboxylic acid transport | 0.0460173561850889 |
| GO:0015849 | organic acid transport | 0.0460173561850889 |
| GO:0005912 | adherens junction | 0.0460173561850889 |
| GO:0022892 | substrate-specific transporter activity | 0.0465164382921448 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| surface structure | 2.64e-12 | 22 |
| zone of skin | 1.49e-09 | 5 |
| skin epidermis | 1.49e-09 | 5 |
| skin of body | 1.49e-09 | 5 |
| integument | 1.49e-09 | 5 |
| surface | 1.49e-09 | 5 |
| outer epithelium | 1.49e-09 | 5 |
| integumental system | 1.49e-09 | 5 |
| enveloping layer of ectoderm | 1.49e-09 | 5 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.04894 |
| MA0004.1 | 0.536396 |
| MA0006.1 | 0.945134 |
| MA0007.1 | 0.52077 |
| MA0009.1 | 0.987341 |
| MA0014.1 | 0.0315641 |
| MA0017.1 | 0.387481 |
| MA0019.1 | 0.800946 |
| MA0024.1 | 0.942716 |
| MA0025.1 | 1.22395 |
| MA0027.1 | 2.64231 |
| MA0028.1 | 0.370592 |
| MA0029.1 | 0.920529 |
| MA0030.1 | 0.927235 |
| MA0031.1 | 0.890871 |
| MA0038.1 | 0.686534 |
| MA0040.1 | 1.00009 |
| MA0041.1 | 2.01886 |
| MA0042.1 | 0.443591 |
| MA0043.1 | 1.08567 |
| MA0046.1 | 1.02391 |
| MA0048.1 | 0.161427 |
| MA0050.1 | 0.57678 |
| MA0051.1 | 0.695779 |
| MA0052.1 | 1.00829 |
| MA0055.1 | 0.212634 |
| MA0056.1 | 0 |
| MA0057.1 | 0.149949 |
| MA0058.1 | 0.436487 |
| MA0059.1 | 0.449345 |
| MA0060.1 | 0.275911 |
| MA0061.1 | 0.307097 |
| MA0063.1 | 0 |
| MA0066.1 | 0.675169 |
| MA0067.1 | 1.33603 |
| MA0068.1 | 7.1726 |
| MA0069.1 | 1.00864 |
| MA0070.1 | 0.998765 |
| MA0071.1 | 0.575909 |
| MA0072.1 | 0.990133 |
| MA0073.1 | 6.52667 |
| MA0074.1 | 0.638014 |
| MA0076.1 | 0.407465 |
| MA0077.1 | 0.968053 |
| MA0078.1 | 0.729877 |
| MA0081.1 | 0.473489 |
| MA0083.1 | 1.08487 |
| MA0084.1 | 1.66561 |
| MA0087.1 | 1.04109 |
| MA0088.1 | 0.358337 |
| MA0089.1 | 0 |
| MA0090.1 | 0.500693 |
| MA0091.1 | 0.55008 |
| MA0092.1 | 0.501022 |
| MA0093.1 | 0.379257 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.626021 |
| MA0101.1 | 0.458688 |
| MA0103.1 | 1.03097 |
| MA0105.1 | 0.57901 |
| MA0106.1 | 0.737893 |
| MA0107.1 | 0.392331 |
| MA0108.2 | 0.824407 |
| MA0109.1 | 0 |
| MA0111.1 | 0.515457 |
| MA0113.1 | 1.68825 |
| MA0114.1 | 0.304661 |
| MA0115.1 | 1.08851 |
| MA0116.1 | 0.359483 |
| MA0117.1 | 1.05576 |
| MA0119.1 | 0.459301 |
| MA0122.1 | 1.07591 |
| MA0124.1 | 1.28237 |
| MA0125.1 | 1.20757 |
| MA0130.1 | 0 |
| MA0131.1 | 0.796279 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.1226 |
| MA0136.1 | 0.658622 |
| MA0139.1 | 1.2655 |
| MA0140.1 | 0.625902 |
| MA0141.1 | 0.419361 |
| MA0142.1 | 0.876028 |
| MA0143.1 | 0.725672 |
| MA0144.1 | 0.307873 |
| MA0145.1 | 0.379391 |
| MA0146.1 | 0.0392287 |
| MA0147.1 | 0.858298 |
| MA0148.1 | 0.553294 |
| MA0149.1 | 0.464445 |
| MA0062.2 | 0.591842 |
| MA0035.2 | 0.630778 |
| MA0039.2 | 0.0823004 |
| MA0138.2 | 0.788113 |
| MA0002.2 | 0.246463 |
| MA0137.2 | 0.416331 |
| MA0104.2 | 1.33199 |
| MA0047.2 | 0.685741 |
| MA0112.2 | 0.119197 |
| MA0065.2 | 0.119561 |
| MA0150.1 | 0.520653 |
| MA0151.1 | 0 |
| MA0152.1 | 0.685852 |
| MA0153.1 | 1.13945 |
| MA0154.1 | 0.933846 |
| MA0155.1 | 0.414701 |
| MA0156.1 | 0.406559 |
| MA0157.1 | 1.96555 |
| MA0158.1 | 0 |
| MA0159.1 | 0.331229 |
| MA0160.1 | 0.556423 |
| MA0161.1 | 0 |
| MA0162.1 | 0.176524 |
| MA0163.1 | 3.72829 |
| MA0164.1 | 0.658997 |
| MA0080.2 | 0.393257 |
| MA0018.2 | 0.669032 |
| MA0099.2 | 1.83891 |
| MA0079.2 | 9.24173 |
| MA0102.2 | 1.7182 |
| MA0258.1 | 0.290587 |
| MA0259.1 | 0.833237 |
| MA0442.1 | 0 |
