MCL coexpression mm9:1590
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0042744 | hydrogen peroxide catabolic process | 8.27720250147647e-05 |
| GO:0042743 | hydrogen peroxide metabolic process | 8.27720250147647e-05 |
| GO:0042542 | response to hydrogen peroxide | 8.27720250147647e-05 |
| GO:0000302 | response to reactive oxygen species | 0.000165435203631644 |
| GO:0006800 | oxygen and reactive oxygen species metabolic process | 0.000415176701135355 |
| GO:0004601 | peroxidase activity | 0.000415176701135355 |
| GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor | 0.000415176701135355 |
| GO:0006118 | electron transport | 0.000565232096750131 |
| GO:0006979 | response to oxidative stress | 0.000604669521067218 |
| GO:0006091 | generation of precursor metabolites and energy | 0.00099363694796803 |
| GO:0020037 | heme binding | 0.00277640050018335 |
| GO:0046906 | tetrapyrrole binding | 0.00277640050018335 |
| GO:0005615 | extracellular space | 0.0043754190341142 |
| GO:0016491 | oxidoreductase activity | 0.00438512396045173 |
| GO:0044421 | extracellular region part | 0.00475924687139041 |
| GO:0005506 | iron ion binding | 0.0143974356699051 |
| GO:0044248 | cellular catabolic process | 0.0257939663370462 |
| GO:0042221 | response to chemical stimulus | 0.0261439238351702 |
| GO:0009056 | catabolic process | 0.0378805281744467 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| abdomen element | 5.59e-07 | 49 |
| abdominal segment element | 5.59e-07 | 49 |
| abdominal segment of trunk | 5.59e-07 | 49 |
| abdomen | 5.59e-07 | 49 |
| hematopoietic system | 6.36e-07 | 45 |
| blood island | 6.36e-07 | 45 |
| spleen | 8.04e-07 | 6 |
| cavity lining | 8.04e-07 | 6 |
| serous membrane | 8.04e-07 | 6 |
| gastrointestinal system mesentery | 8.04e-07 | 6 |
| stomach region | 8.04e-07 | 6 |
| mesentery | 8.04e-07 | 6 |
| gastrointestinal system serosa | 8.04e-07 | 6 |
| mesentery of stomach | 8.04e-07 | 6 |
| gut mesentery | 8.04e-07 | 6 |
| dorsal mesentery | 8.04e-07 | 6 |
| dorsal mesogastrium | 8.04e-07 | 6 |
| peritoneal cavity | 8.04e-07 | 6 |
| spleen primordium | 8.04e-07 | 6 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.406907 |
| MA0004.1 | 0.603793 |
| MA0006.1 | 0.419915 |
| MA0007.1 | 0.587678 |
| MA0009.1 | 1.06266 |
| MA0014.1 | 0.0502051 |
| MA0017.1 | 1.14026 |
| MA0019.1 | 0.874061 |
| MA0024.1 | 1.01759 |
| MA0025.1 | 1.30092 |
| MA0027.1 | 2.72141 |
| MA0028.1 | 0.43138 |
| MA0029.1 | 0.995171 |
| MA0030.1 | 1.00195 |
| MA0031.1 | 0.965177 |
| MA0038.1 | 0.757669 |
| MA0040.1 | 1.07552 |
| MA0041.1 | 0.522007 |
| MA0042.1 | 0.507715 |
| MA0043.1 | 1.1618 |
| MA0046.1 | 1.09955 |
| MA0048.1 | 0.205696 |
| MA0050.1 | 0.645342 |
| MA0051.1 | 0.767098 |
| MA0052.1 | 1.08379 |
| MA0055.1 | 0.0851423 |
| MA0056.1 | 0 |
| MA0057.1 | 0.562607 |
| MA0058.1 | 0.50032 |
| MA0059.1 | 0.513699 |
| MA0060.1 | 0.330907 |
| MA0061.1 | 0.955135 |
| MA0063.1 | 0 |
| MA0066.1 | 0.746072 |
| MA0067.1 | 1.41352 |
| MA0068.1 | 0.197245 |
| MA0069.1 | 1.08414 |
| MA0070.1 | 1.07418 |
| MA0071.1 | 0.644448 |
| MA0072.1 | 1.06547 |
| MA0073.1 | 0.0176764 |
| MA0074.1 | 0.708108 |
| MA0076.1 | 0.470037 |
| MA0077.1 | 1.04318 |
| MA0078.1 | 0.801834 |
| MA0081.1 | 0.53877 |
| MA0083.1 | 1.16099 |
| MA0084.1 | 1.74401 |
| MA0087.1 | 1.11687 |
| MA0088.1 | 0.148348 |
| MA0089.1 | 0 |
| MA0090.1 | 0.566938 |
| MA0091.1 | 0.617887 |
| MA0092.1 | 0.567278 |
| MA0093.1 | 0.440484 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.695835 |
| MA0101.1 | 0.523409 |
| MA0103.1 | 0.460936 |
| MA0105.1 | 1.28296 |
| MA0106.1 | 0.809991 |
| MA0107.1 | 0.454197 |
| MA0108.2 | 2.07761 |
| MA0109.1 | 0 |
| MA0111.1 | 0.582193 |
| MA0113.1 | 0.780358 |
| MA0114.1 | 0.361633 |
| MA0115.1 | 1.16466 |
| MA0116.1 | 0.419688 |
| MA0117.1 | 1.13165 |
| MA0119.1 | 0.524046 |
| MA0122.1 | 1.15196 |
| MA0124.1 | 1.35963 |
| MA0125.1 | 1.28445 |
| MA0130.1 | 0 |
| MA0131.1 | 0.869325 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.19898 |
| MA0136.1 | 0.729175 |
| MA0139.1 | 0.295945 |
| MA0140.1 | 1.6611 |
| MA0141.1 | 1.21195 |
| MA0142.1 | 0.950155 |
| MA0143.1 | 0.797553 |
| MA0144.1 | 0.365053 |
| MA0145.1 | 0.157686 |
| MA0146.1 | 0.0604336 |
| MA0147.1 | 0.378658 |
| MA0148.1 | 0.621195 |
| MA0149.1 | 0.529387 |
| MA0062.2 | 0.254018 |
| MA0035.2 | 0.700704 |
| MA0039.2 | 0.140205 |
| MA0138.2 | 0.861035 |
| MA0002.2 | 0.809945 |
| MA0137.2 | 0.479301 |
| MA0104.2 | 0.315156 |
| MA0047.2 | 0.75686 |
| MA0112.2 | 0.47695 |
| MA0065.2 | 0.158101 |
| MA0150.1 | 0.587557 |
| MA0151.1 | 0 |
| MA0152.1 | 0.756973 |
| MA0153.1 | 1.21594 |
| MA0154.1 | 0.587595 |
| MA0155.1 | 0.515751 |
| MA0156.1 | 0.469089 |
| MA0157.1 | 0.91689 |
| MA0158.1 | 0 |
| MA0159.1 | 0.389847 |
| MA0160.1 | 0.624415 |
| MA0161.1 | 0 |
| MA0162.1 | 0.245828 |
| MA0163.1 | 0.230013 |
| MA0164.1 | 0.729558 |
| MA0080.2 | 0.455167 |
| MA0018.2 | 0.739807 |
| MA0099.2 | 0.854449 |
| MA0079.2 | 0.0381166 |
| MA0102.2 | 1.79669 |
| MA0258.1 | 0.346619 |
| MA0259.1 | 0.366802 |
| MA0442.1 | 0 |
