MCL coexpression mm9:75
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0008544 | epidermis development | 4.37505799626704e-08 |
| GO:0007398 | ectoderm development | 4.37505799626704e-08 |
| GO:0009888 | tissue development | 1.96428993550715e-05 |
| GO:0030057 | desmosome | 2.53581179068666e-05 |
| GO:0008233 | peptidase activity | 0.000114933984441675 |
| GO:0016787 | hydrolase activity | 0.000114933984441675 |
| GO:0030054 | cell junction | 0.000143025842598808 |
| GO:0031424 | keratinization | 0.000214087444236872 |
| GO:0009913 | epidermal cell differentiation | 0.000554772196953506 |
| GO:0014704 | intercalated disc | 0.00138032072496803 |
| GO:0048730 | epidermis morphogenesis | 0.00176392650888208 |
| GO:0048729 | tissue morphogenesis | 0.00808970761995868 |
| GO:0003810 | protein-glutamine gamma-glutamyltransferase activity | 0.00808970761995868 |
| GO:0018149 | peptide cross-linking | 0.00808970761995868 |
| GO:0005911 | intercellular junction | 0.00930381502823334 |
| GO:0001726 | ruffle | 0.00930381502823334 |
| GO:0016165 | lipoxygenase activity | 0.00930381502823334 |
| GO:0043296 | apical junction complex | 0.010602239102886 |
| GO:0016327 | apicolateral plasma membrane | 0.0109428847960425 |
| GO:0044459 | plasma membrane part | 0.0129403618494906 |
| GO:0004867 | serine-type endopeptidase inhibitor activity | 0.0153275580725187 |
| GO:0016755 | transferase activity, transferring amino-acyl groups | 0.0223162804335706 |
| GO:0004293 | tissue kallikrein activity | 0.0251646083949542 |
| GO:0019370 | leukotriene biosynthetic process | 0.035111495357553 |
| GO:0043450 | alkene biosynthetic process | 0.035111495357553 |
| GO:0022610 | biological adhesion | 0.035111495357553 |
| GO:0007155 | cell adhesion | 0.035111495357553 |
| GO:0006691 | leukotriene metabolic process | 0.0356860640717871 |
| GO:0043449 | alkene metabolic process | 0.0376507214843083 |
| GO:0006508 | proteolysis | 0.0376507214843083 |
| GO:0004866 | endopeptidase inhibitor activity | 0.0376507214843083 |
| GO:0030414 | protease inhibitor activity | 0.0393279550420495 |
| GO:0005509 | calcium ion binding | 0.0455591662483469 |
| GO:0031252 | leading edge | 0.0480286345623551 |
| GO:0046456 | icosanoid biosynthetic process | 0.0480286345623551 |
| GO:0051015 | actin filament binding | 0.0480286345623551 |
| GO:0004231 | insulysin activity | 0.0480286345623551 |
| GO:0043758 | acetate-CoA ligase (ADP-forming) activity | 0.0480286345623551 |
| GO:0030280 | structural constituent of epidermis | 0.0480286345623551 |
| GO:0017039 | dipeptidyl-peptidase III activity | 0.0480286345623551 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| zone of skin | 1.25e-09 | 5 |
| skin epidermis | 1.25e-09 | 5 |
| skin of body | 1.25e-09 | 5 |
| integument | 1.25e-09 | 5 |
| surface | 1.25e-09 | 5 |
| outer epithelium | 1.25e-09 | 5 |
| integumental system | 1.25e-09 | 5 |
| enveloping layer of ectoderm | 1.25e-09 | 5 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.000585908 |
| MA0004.1 | 0.0986669 |
| MA0006.1 | 0.0378654 |
| MA0007.1 | 0.303724 |
| MA0009.1 | 1.33674 |
| MA0014.1 | 0.00715778 |
| MA0017.1 | 0.0230026 |
| MA0019.1 | 0.839275 |
| MA0024.1 | 0.157257 |
| MA0025.1 | 0.0762252 |
| MA0027.1 | 1.18416 |
| MA0028.1 | 0.00743963 |
| MA0029.1 | 0.0495367 |
| MA0030.1 | 0.290104 |
| MA0031.1 | 0.234704 |
| MA0038.1 | 0.423786 |
| MA0040.1 | 0.218796 |
| MA0041.1 | 0.00559549 |
| MA0042.1 | 0.00984954 |
| MA0043.1 | 0.142016 |
| MA0046.1 | 0.0233559 |
| MA0048.1 | 0.298918 |
| MA0050.1 | 0.16022 |
| MA0051.1 | 0.183208 |
| MA0052.1 | 0.228508 |
| MA0055.1 | 3.97418 |
| MA0056.1 | 0 |
| MA0057.1 | 0.012646 |
| MA0058.1 | 0.00833912 |
| MA0059.1 | 0.0450911 |
| MA0060.1 | 0.101784 |
| MA0061.1 | 0.045281 |
| MA0063.1 | 0 |
| MA0066.1 | 0.0360557 |
| MA0067.1 | 0.388781 |
| MA0068.1 | 0.117139 |
| MA0069.1 | 0.0208374 |
| MA0070.1 | 0.217253 |
| MA0071.1 | 0.36354 |
| MA0072.1 | 0.207316 |
| MA0073.1 | 0.00790239 |
| MA0074.1 | 0.427285 |
| MA0076.1 | 0.000456441 |
| MA0077.1 | 0.0702307 |
| MA0078.1 | 0.0255065 |
| MA0081.1 | 0.174789 |
| MA0083.1 | 0.141424 |
| MA0084.1 | 0.321696 |
| MA0087.1 | 0.111308 |
| MA0088.1 | 0.0309949 |
| MA0089.1 | 0 |
| MA0090.1 | 0.782072 |
| MA0091.1 | 0.0335008 |
| MA0092.1 | 0.470589 |
| MA0093.1 | 0.0580788 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.0917639 |
| MA0101.1 | 0.0286115 |
| MA0103.1 | 1.91471 |
| MA0105.1 | 0.852028 |
| MA0106.1 | 0.406461 |
| MA0107.1 | 0.045634 |
| MA0108.2 | 0.278569 |
| MA0109.1 | 0 |
| MA0111.1 | 0.697553 |
| MA0113.1 | 0.331324 |
| MA0114.1 | 0.138767 |
| MA0115.1 | 0.144116 |
| MA0116.1 | 0.572967 |
| MA0117.1 | 0.120938 |
| MA0119.1 | 0.684326 |
| MA0122.1 | 0.910727 |
| MA0124.1 | 0.326114 |
| MA0125.1 | 0.247207 |
| MA0130.1 | 0 |
| MA0131.1 | 0.120516 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.686288 |
| MA0136.1 | 0.00997512 |
| MA0139.1 | 0.0404792 |
| MA0140.1 | 0.260769 |
| MA0141.1 | 1.2642 |
| MA0142.1 | 0.0342298 |
| MA0143.1 | 0.00649933 |
| MA0144.1 | 0.932392 |
| MA0145.1 | 1.89411 |
| MA0146.1 | 0.494164 |
| MA0147.1 | 0.00329624 |
| MA0148.1 | 0.0694854 |
| MA0149.1 | 0.0155339 |
| MA0062.2 | 1.86518e-06 |
| MA0035.2 | 0.170492 |
| MA0039.2 | 1.82845 |
| MA0138.2 | 0.364407 |
| MA0002.2 | 1.33591 |
| MA0137.2 | 0.56115 |
| MA0104.2 | 0.00141317 |
| MA0047.2 | 0.0409185 |
| MA0112.2 | 0.0684597 |
| MA0065.2 | 0.323426 |
| MA0150.1 | 0.207637 |
| MA0151.1 | 0 |
| MA0152.1 | 0.811199 |
| MA0153.1 | 0.049201 |
| MA0154.1 | 1.09587 |
| MA0155.1 | 0.208593 |
| MA0156.1 | 0.0187257 |
| MA0157.1 | 0.313515 |
| MA0158.1 | 0 |
| MA0159.1 | 0.303697 |
| MA0160.1 | 0.753076 |
| MA0161.1 | 0 |
| MA0162.1 | 0.00633919 |
| MA0163.1 | 0.0254033 |
| MA0164.1 | 0.130167 |
| MA0080.2 | 0.118113 |
| MA0018.2 | 0.0754108 |
| MA0099.2 | 2.44162 |
| MA0079.2 | 5.92363e-07 |
| MA0102.2 | 0.360273 |
| MA0258.1 | 0.329924 |
| MA0259.1 | 0.0173239 |
| MA0442.1 | 0 |
