MCL coexpression mm9:974

Phase1 CAGE Peaks

	Short description
Mm9::chr18:35899649..35899675,-	p@chr18:35899649..35899675 -
Mm9::chr1:108608936..108608961,-	p@chr1:108608936..108608961 -
Mm9::chr1:108608965..108609005,-	p@chr1:108608965..108609005 -
Mm9::chr1:108609006..108609033,-	p@chr1:108609006..108609033 -
Mm9::chr1:108610539..108610626,-	p2@Bcl2
Mm9::chr1:108610794..108610907,-	p1@Bcl2
Mm9::chr1:36824259..36824270,+	p@chr1:36824259..36824270 +
Mm9::chrX:7455424..7455440,+	p1@Pim2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008637	apoptotic mitochondrial changes	0.000390873835132874
GO:0008632	apoptotic program	0.00134258362392082
GO:0007005	mitochondrion organization and biogenesis	0.00168168780260459
GO:0006916	anti-apoptosis	0.00171237262068775
GO:0045069	regulation of viral genome replication	0.00368027499270053
GO:0043066	negative regulation of apoptosis	0.00368027499270053
GO:0043069	negative regulation of programmed cell death	0.00368027499270053
GO:0050792	regulation of viral reproduction	0.00417442749767467
GO:0019079	viral genome replication	0.00417442749767467
GO:0046902	regulation of mitochondrial membrane permeability	0.00417442749767467
GO:0019058	viral infectious cycle	0.00521774847851113
GO:0051881	regulation of mitochondrial membrane potential	0.00521774847851113
GO:0022415	viral reproductive process	0.00802642572719521
GO:0016032	viral reproduction	0.00894324147501408
GO:0042981	regulation of apoptosis	0.0099930817688357
GO:0043067	regulation of programmed cell death	0.0099930817688357
GO:0001836	release of cytochrome c from mitochondria	0.013498842062112
GO:0007006	mitochondrial membrane organization and biogenesis	0.0150652381159983
GO:0031069	hair follicle morphogenesis	0.0153693601552006
GO:0006915	apoptosis	0.0191118344438876
GO:0012501	programmed cell death	0.0191118344438876
GO:0008219	cell death	0.0191118344438876
GO:0016265	death	0.0191118344438876
GO:0006839	mitochondrial transport	0.0191118344438876
GO:0043524	negative regulation of neuron apoptosis	0.0191802807039359
GO:0043523	regulation of neuron apoptosis	0.0255853503827637
GO:0048523	negative regulation of cellular process	0.0255853503827637
GO:0051402	neuron apoptosis	0.0255853503827637
GO:0022404	molting cycle process	0.0255853503827637
GO:0001942	hair follicle development	0.0255853503827637
GO:0022405	hair cycle process	0.0255853503827637
GO:0048519	negative regulation of biological process	0.0255853503827637
GO:0042391	regulation of membrane potential	0.0255853503827637
GO:0042633	hair cycle	0.0255853503827637
GO:0042303	molting cycle	0.0255853503827637
GO:0048730	epidermis morphogenesis	0.0283362027210767
GO:0007242	intracellular signaling cascade	0.0288821106596986
GO:0046982	protein heterodimerization activity	0.032851388256512
GO:0006996	organelle organization and biogenesis	0.0335915438424823
GO:0048468	cell development	0.0335915438424823
GO:0048729	tissue morphogenesis	0.0380282311161415
GO:0008544	epidermis development	0.0474624550720922
GO:0007398	ectoderm development	0.0487598082243745

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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