MCL coexpression mm9:2277

Phase1 CAGE Peaks

	Short description
Mm9::chr19:7292013..7292018,-	p3@Cox8a p3@LOC100048483
Mm9::chr19:7292019..7292033,-	p2@Cox8a p2@LOC100048483
Mm9::chr19:7292039..7292070,-	p1@Cox8a p1@LOC100048483
Mm9::chr5:115798962..115798968,-	p1@Cox6a1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004129	cytochrome-c oxidase activity	1.13461125138868e-05
GO:0016675	oxidoreductase activity, acting on heme group of donors	1.13461125138868e-05
GO:0016676	oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	1.13461125138868e-05
GO:0015002	heme-copper terminal oxidase activity	1.13461125138868e-05
GO:0015078	hydrogen ion transmembrane transporter activity	0.000164248485915314
GO:0015077	monovalent inorganic cation transmembrane transporter activity	0.000164248485915314
GO:0022890	inorganic cation transmembrane transporter activity	0.000262890198791146
GO:0006118	electron transport	0.00132752217867836
GO:0006091	generation of precursor metabolites and energy	0.00200354337292838
GO:0008324	cation transmembrane transporter activity	0.00224199183274404
GO:0015075	ion transmembrane transporter activity	0.00377005286630258
GO:0022891	substrate-specific transmembrane transporter activity	0.00458420765936074
GO:0016491	oxidoreductase activity	0.0047569885881299
GO:0022857	transmembrane transporter activity	0.00527248445609599
GO:0022892	substrate-specific transporter activity	0.00571006619538157
GO:0005739	mitochondrion	0.00571006619538157

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
mucosa	3.18e-09	15
intestine	1.34e-08	31
intestinal mucosa	4.58e-08	13
anatomical wall	4.58e-08	13
wall of intestine	4.58e-08	13
gastrointestinal system mucosa	4.58e-08	13

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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