MCL coexpression mm9:587

Phase1 CAGE Peaks

	Short description
Mm9::chr10:121023786..121023859,-	p1@Tbk1
Mm9::chr10:79459200..79459220,+	p2@Abca7
Mm9::chr11:120486287..120486312,-	p1@Sirt7
Mm9::chr11:69224513..69224543,-	p@chr11:69224513..69224543 -
Mm9::chr1:95721847..95721882,+	p2@D2hgdh
Mm9::chr2:181316679..181316695,-	p1@Uckl1
Mm9::chr3:35653043..35653057,+	p1@Atp11b
Mm9::chr4:134479531..134479543,+	p1@D4Wsu53e
Mm9::chr4:154998962..154999038,+	p1@Cdk11b
Mm9::chr6:56664885..56664945,+	p1@Avl9
Mm9::chr8:86222994..86223105,-	p1@Pkn1
Mm9::chr9:96531906..96531973,-	p1@Rasa2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030554	adenyl nucleotide binding	0.000581269972159091
GO:0017076	purine nucleotide binding	0.000999727131268797
GO:0000166	nucleotide binding	0.00137670865549461
GO:0005524	ATP binding	0.00243065589320011
GO:0032559	adenyl ribonucleotide binding	0.00243065589320011
GO:0032553	ribonucleotide binding	0.00499779722893616
GO:0032555	purine ribonucleotide binding	0.00499779722893616
GO:0051990	(R)-2-hydroxyglutarate dehydrogenase activity	0.0076699720593875
GO:0032025	response to cobalt ion	0.0076699720593875
GO:0010042	response to manganese ion	0.0076699720593875
GO:0010043	response to zinc ion	0.0139427295764083
GO:0006972	hyperosmotic response	0.0255518688309197
GO:0004849	uridine kinase activity	0.0294772723990682
GO:0005677	chromatin silencing complex	0.0437696187419012
GO:0010038	response to metal ion	0.045218395249302
GO:0016301	kinase activity	0.045218395249302
GO:0006970	response to osmotic stress	0.045218395249302
GO:0019206	nucleoside kinase activity	0.045218395249302
GO:0016887	ATPase activity	0.045218395249302
GO:0010035	response to inorganic substance	0.045218395249302
GO:0006342	chromatin silencing	0.045218395249302
GO:0031507	heterochromatin formation	0.045218395249302
GO:0045814	negative regulation of gene expression, epigenetic	0.0476710522172964
GO:0004697	protein kinase C activity	0.0476710522172964
GO:0016772	transferase activity, transferring phosphorus-containing groups	0.0476710522172964
GO:0016787	hydrolase activity	0.0481444912763527
GO:0001565	phorbol ester receptor activity	0.0481444912763527

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	5.47e-13	118
endoderm	5.47e-13	118
presumptive endoderm	5.47e-13	118
digestive system	1.96e-12	116
digestive tract	1.96e-12	116
primitive gut	1.96e-12	116
subdivision of digestive tract	1.25e-11	114
gastrointestinal system	1.57e-09	47
intestine	1.59e-09	31
adult organism	1.48e-08	51
organ component layer	6.64e-08	24
mucosa	7.76e-07	15

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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