MCL coexpression mm9:674

Phase1 CAGE Peaks

	Short description
Mm9::chr15:89165417..89165448,+	p2@Miox
Mm9::chr16:22899188..22899189,-	p@chr16:22899188..22899189 -
Mm9::chr1:174825056..174825089,-	p1@Apcs
Mm9::chr1:174825099..174825111,-	p6@Apcs
Mm9::chr1:174825114..174825134,-	p4@Apcs
Mm9::chr1:174825139..174825146,-	p5@Apcs
Mm9::chr1:174825156..174825175,-	p3@Apcs
Mm9::chr3:82846342..82846366,+	p@chr3:82846342..82846366 +
Mm9::chr3:82847141..82847172,+	p@chr3:82847141..82847172 +
Mm9::chr7:107699259..107699268,-	p@chr7:107699259..107699268 -
Mm9::chr8:23674552..23674588,+	p@chr8:23674552..23674588 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0050113	inositol oxygenase activity	0.00219142058839643
GO:0004033	aldo-keto reductase activity	0.0164293510171321
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	0.0360940550224503
GO:0016651	oxidoreductase activity, acting on NADH or NADPH	0.0360940550224503
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.0433226793136719
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	0.0433226793136719

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
liver	3.71e-27	22
epithelial sac	3.71e-27	22
digestive gland	3.71e-27	22
epithelium of foregut-midgut junction	3.71e-27	22
anatomical boundary	3.71e-27	22
hepatobiliary system	3.71e-27	22
foregut-midgut junction	3.71e-27	22
hepatic diverticulum	3.71e-27	22
liver primordium	3.71e-27	22
septum transversum	3.71e-27	22
liver bud	3.71e-27	22
digestive tract diverticulum	1.15e-25	23
sac	1.15e-25	23
exocrine gland	4.83e-23	25
exocrine system	4.83e-23	25
abdomen element	2.33e-13	49
abdominal segment element	2.33e-13	49
abdominal segment of trunk	2.33e-13	49
abdomen	2.33e-13	49
trunk mesenchyme	4.90e-13	45
mesenchyme	2.98e-09	61
entire embryonic mesenchyme	2.98e-09	61
epithelial tube	3.71e-09	47
endocrine gland	4.92e-08	60
subdivision of trunk	5.20e-08	66
gut epithelium	5.81e-07	55
gland	6.44e-07	65
endocrine system	7.35e-07	72
trunk region element	9.32e-07	79

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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