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{{Coexpression_clusters
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|full_id=C968_Mesenchymal_testis_MCF7_mature_Adipocyte_Fibroblast_Alveolar
|id=C968
|ontology_enrichment_celltype=CL:0000183!4.20e-08!59;CL:0000055!9.12e-08!180;CL:0000680!2.30e-07!57;CL:0000056!2.30e-07!57;CL:0000355!2.30e-07!57;CL:0000136!4.02e-07!15;CL:0000393!4.66e-07!60;CL:0000211!4.66e-07!60;CL:0000187!8.42e-07!54
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0004535!1.63e-07!110;UBERON:0002049!2.67e-07!79;UBERON:0007798!2.67e-07!79;UBERON:0001009!5.61e-07!113
|tf_chipseq_enrich=CCNT2#905;5:3.96012598560165:0.0035982129138552:0.018224721557232!CHD2#1106;4:5.17201141705843:0.00443788460794178:0.0210046329452022!E2F1#1869;6:3.68054191115949:0.00136649155081914:0.00899332100800302!E2F6#1876;6:3.76286679877304:0.00120768002799781:0.00818699821135035!ELF1#1997;7:3.7258357139566:0.000250341272551272:0.00269901849530116!GABPB1#2553;7:6.1842233566594:7.95182205325426e-06:0.000221225451097448!HEY1#23462;6:3.03008328232928:0.00400172346648327:0.0191880995875326!HMGN3#9324;4:4.0892738616753:0.0103942462239878:0.0385909947169236!IRF1#3659;5:4.77322734597744:0.00152554848029467:0.00971445385851443!IRF3#3661;2:11.7454880528724:0.0116448804945314:0.042532687765558!NFYA#4800;3:6.90959276243645:0.00727972723713068:0.0301247100768164!NFYB#4801;3:6.28492247007617:0.00947376901248262:0.0356989090018283!PBX3#5090;4:10.9572563433721:0.000261492197563197:0.00280188607995309!POLR2A#5430;8:2.14745317655807:0.00221072578897191:0.012728003896055!SIN3A#25942;6:4.05666354511135:0.00079220890752307:0.00612825021056232!SP1#6667;6:4.27378603360567:0.000590472686428894:0.00494454593472958!SP2#6668;3:9.80757393519174:0.00270718466508561:0.0148886603073658!SREBF1#6720;2:11.7514623601221:0.0116335478572343:0.0424957540716203!TAF1#6872;8:3.34304628574529:6.40776711117462e-05:0.0010441890924075!YY1#7528;5:3.06948171865866:0.011259136535836:0.0413319142589167!ZNF143#7702;4:6.75043827611395:0.00165129218914978:0.0103262861470938
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}}

Latest revision as of 11:34, 17 September 2013


Full id: C968_Mesenchymal_testis_MCF7_mature_Adipocyte_Fibroblast_Alveolar



Phase1 CAGE Peaks

Hg19::chr10:104262056..104262066,+p@chr10:104262056..104262066
+
Hg19::chr12:14927378..14927389,+p3@H2AFJ
Hg19::chr1:110752586..110752596,-p1@KCNC4-AS1
Hg19::chr20:60758060..60758074,-p@chr20:60758060..60758074
-
Hg19::chr2:24346422..24346436,+p2@AK098250
Hg19::chr3:44771012..44771024,-p@chr3:44771012..44771024
-
Hg19::chr7:130080681..130080699,-p4@CEP41
Hg19::chr8:103875754..103875768,+p@chr8:103875754..103875768
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
olfactory region2.84e-071
primary subdivision of skull2.84e-071
cranium2.84e-071
neurocranium2.84e-071
chondrocranium2.84e-071
cartilaginous neurocranium2.84e-071
head paraxial mesoderm2.84e-071
nucleus accumbens3.82e-071
ventral striatum3.82e-071
insula9.18e-071


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.40022
MA0004.10.455723
MA0006.10.300178
MA0007.10.437331
MA0009.10.918715
MA0014.11.38556
MA0017.10.896777
MA0019.10.602411
MA0024.11.90464
MA0025.11.05265
MA0027.12.5321
MA0028.13.21619
MA0029.10.832916
MA0030.10.821423
MA0031.10.756713
MA0038.10.557409
MA0040.10.838784
MA0041.10.474018
MA0042.10.442535
MA0043.10.919032
MA0046.10.90778
MA0048.10.653157
MA0050.10.443405
MA0051.10.553205
MA0052.10.842664
MA0055.10.283474
MA0056.10
MA0057.10.0912556
MA0058.10.362328
MA0059.10.361075
MA0060.13.1469
MA0061.10.165998
MA0063.10
MA0066.11.3723
MA0067.11.23721
MA0068.10.133123
MA0069.10.903908
MA0070.10.892666
MA0071.10.518907
MA0072.10.888148
MA0073.10.466265
MA0074.10.552456
MA0076.12.62795
MA0077.10.880402
MA0078.10.652193
MA0081.10.361233
MA0083.10.926258
MA0084.11.42483
MA0087.10.885691
MA0088.10.770971
MA0089.10
MA0090.10.391903
MA0091.10.458301
MA0092.10.421159
MA0093.10.303084
MA0095.10
MA0098.10
MA0100.10.571227
MA0101.10.30624
MA0103.10.291333
MA0105.10.279181
MA0106.10.59853
MA0107.10.236528
MA0108.20.753643
MA0109.10
MA0111.10.405141
MA0113.10.614917
MA0114.11.22129
MA0115.11.1606
MA0116.10.673701
MA0117.10.956472
MA0119.10.345493
MA0122.10.982472
MA0124.11.11898
MA0125.11.0347
MA0130.10
MA0131.10.670358
MA0132.10
MA0133.10
MA0135.10.949204
MA0136.10.564434
MA0139.10.916926
MA0140.10.516266
MA0141.10.359385
MA0142.10.724856
MA0143.10.615094
MA0144.10.623945
MA0145.10.480646
MA0146.11.63914
MA0147.10.243042
MA0148.10.480298
MA0149.10.506665
MA0062.26.33633
MA0035.20.515566
MA0039.20.881644
MA0138.20.653421
MA0002.20.179788
MA0137.20.321796
MA0104.20.55506
MA0047.20.586412
MA0112.21.69642
MA0065.20.844872
MA0150.10.386144
MA0151.10
MA0152.10.52279
MA0153.11.01778
MA0154.10.274121
MA0155.11.16939
MA0156.10.865715
MA0157.10.697424
MA0158.10
MA0159.10.682702
MA0160.10.495355
MA0161.10
MA0162.11.70684
MA0163.11.42814
MA0164.10.627336
MA0080.20.303167
MA0018.20.599912
MA0099.20.523145
MA0079.23.09265
MA0102.21.46209
MA0258.11.13653
MA0259.10.25092
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90553.960125985601650.00359821291385520.018224721557232
CHD2#110645.172011417058430.004437884607941780.0210046329452022
E2F1#186963.680541911159490.001366491550819140.00899332100800302
E2F6#187663.762866798773040.001207680027997810.00818699821135035
ELF1#199773.72583571395660.0002503412725512720.00269901849530116
GABPB1#255376.18422335665947.95182205325426e-060.000221225451097448
HEY1#2346263.030083282329280.004001723466483270.0191880995875326
HMGN3#932444.08927386167530.01039424622398780.0385909947169236
IRF1#365954.773227345977440.001525548480294670.00971445385851443
IRF3#3661211.74548805287240.01164488049453140.042532687765558
NFYA#480036.909592762436450.007279727237130680.0301247100768164
NFYB#480136.284922470076170.009473769012482620.0356989090018283
PBX3#5090410.95725634337210.0002614921975631970.00280188607995309
POLR2A#543082.147453176558070.002210725788971910.012728003896055
SIN3A#2594264.056663545111350.000792208907523070.00612825021056232
SP1#666764.273786033605670.0005904726864288940.00494454593472958
SP2#666839.807573935191740.002707184665085610.0148886603073658
SREBF1#6720211.75146236012210.01163354785723430.0424957540716203
TAF1#687283.343046285745296.40776711117462e-050.0010441890924075
YY1#752853.069481718658660.0112591365358360.0413319142589167
ZNF143#770246.750438276113950.001651292189149780.0103262861470938



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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