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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,

Latest revision as of 11:45, 17 September 2013


Full id: C1471_salivary_kidney_submaxillary_parotid_adenocarcinoma_trachea_ductus



Phase1 CAGE Peaks

Hg19::chr1:217311090..217311097,-p26@ESRRG
Hg19::chr7:138482733..138482757,+p1@TMEM213
Hg19::chr7:138482916..138482927,-p3@ATP6V0A4
Hg19::chr7:138482933..138482946,-p2@ATP6V0A4
Hg19::chr7:138482949..138482954,-p10@ATP6V0A4
Hg19::chr7:138484401..138484416,-p8@ATP6V0A4


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0050682AF-2 domain binding0.0159284217538759
GO:0033176proton-transporting V-type ATPase complex0.0159284217538759
GO:0016471vacuolar proton-transporting V-type ATPase complex0.0159284217538759
GO:0031526brush border membrane0.0159284217538759
GO:0031253cell projection membrane0.0159284217538759
GO:0005903brush border0.0277491655280892
GO:0016439tRNA-pseudouridine synthase activity0.0297538403539397
GO:0006885regulation of pH0.0297538403539397
GO:0009982pseudouridine synthase activity0.0297538403539397
GO:0007588excretion0.0303949284521266
GO:0044463cell projection part0.0309189706234276
GO:0005774vacuolar membrane0.0327946621331735
GO:0044437vacuolar part0.0327946621331735
GO:0016324apical plasma membrane0.0327946621331735
GO:0016866intramolecular transferase activity0.0327946621331735
GO:0005496steroid binding0.0334955096926417
GO:0045177apical part of cell0.0334955096926417
GO:0031214biomineral formation0.0334955096926417
GO:0001503ossification0.0334955096926417
GO:0046849bone remodeling0.0347094355554021
GO:0048771tissue remodeling0.0348443475486375
GO:0016469proton-transporting two-sector ATPase complex0.0348443475486375
GO:0003707steroid hormone receptor activity0.0348443475486375
GO:0019904protein domain specific binding0.0348443475486375
GO:0050954sensory perception of mechanical stimulus0.0348443475486375
GO:0007605sensory perception of sound0.0348443475486375
GO:0015992proton transport0.0348443475486375
GO:0006818hydrogen transport0.0348443475486375
GO:0004879ligand-dependent nuclear receptor activity0.0381184060088978
GO:0015078hydrogen ion transmembrane transporter activity0.0486706314057502
GO:0001501skeletal development0.0486706314057502
GO:0015077monovalent inorganic cation transmembrane transporter activity0.0487734568188069
GO:0045893positive regulation of transcription, DNA-dependent0.0487734568188069
GO:0005773vacuole0.0494544620923417



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.026277
MA0004.10.558729
MA0006.10.391183
MA0007.11.33289
MA0009.11.03681
MA0014.10.262822
MA0017.11.10421
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.10.152639
MA0050.10.545671
MA0051.10.661179
MA0052.10.959373
MA0055.10.465994
MA0056.10
MA0057.12.04333
MA0058.10.458909
MA0059.10.457555
MA0060.10.267412
MA0061.10.23892
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.10.578694
MA0069.11.02175
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.17.76605
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.11.61871
MA0089.10
MA0090.10.490736
MA0091.10.561458
MA0092.10.522012
MA0093.10.394379
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.10.397846
MA0103.10.993014
MA0105.10.134725
MA0106.10.70837
MA0107.10.320267
MA0108.20.868347
MA0109.10
MA0111.10.504913
MA0113.10.725375
MA0114.13.21192
MA0115.11.28169
MA0116.10.323925
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.10.672893
MA0139.10.226048
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.10.299851
MA0145.10.107156
MA0146.10.0213085
MA0147.10.327615
MA0148.10.584698
MA0149.19.13818
MA0062.20.23336
MA0035.20.621793
MA0039.20.200862
MA0138.20.765223
MA0002.20.255126
MA0137.20.414885
MA0104.20.26661
MA0047.20.695777
MA0112.22.25875
MA0065.24.55645
MA0150.10.484557
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.10.413181
MA0155.12.84974
MA0156.10.417278
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.10.600559
MA0161.10
MA0162.10.347838
MA0163.10.273773
MA0164.10.738243
MA0080.20.394469
MA0018.20.709805
MA0099.20.629739
MA0079.24.76174
MA0102.21.58513
MA0258.13.98052
MA0259.10.336472
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066443.573504248716680.01316635007238510.0466113160641954
NANOG#79923419.49651898734181.9383725252986e-050.000437239067321081
RAD21#588546.903355930304220.00111085151625360.00771435743772925



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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