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Coexpression cluster:C2388: Difference between revisions

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{{Coexpression_clusters
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|full_id=C2388_granulocyte_non_Hodgkin_Burkitt_acute_Reticulocytes_embryonic
|id=C2388
}}

Latest revision as of 12:04, 17 September 2013


Full id: C2388_granulocyte_non_Hodgkin_Burkitt_acute_Reticulocytes_embryonic



Phase1 CAGE Peaks

Hg19::chr16:72698834..72698913,-p@chr16:72698834..72698913
-
Hg19::chr1:93646238..93646298,+p1@CCDC18
Hg19::chr3:121264813..121264846,-p1@POLQ
Hg19::chr3:121264848..121264859,-p2@POLQ


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0003887DNA-directed DNA polymerase activity0.0288472860002355
GO:0003684damaged DNA binding0.0288472860002355



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>

Disease
Ontology termp-valuen
cancer9.04e-46235
disease of cellular proliferation3.45e-44239
hematologic cancer1.34e-2651
immune system cancer1.34e-2651
organ system cancer2.59e-26137
leukemia2.72e-2139
cell type cancer8.61e-20143
myeloid leukemia6.94e-1731
carcinoma9.92e-16106
lymphoma6.88e-0710


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.233555
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.12.32784
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.791759
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.11.80156
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.0343867
MA0074.10.819248
MA0076.13.73908
MA0077.11.16637
MA0078.10.926725
MA0081.11.4709
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.11.9583
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.08195
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.21.66396
MA0035.20.778873
MA0039.20.483275
MA0138.20.928035
MA0002.20.98779
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.11.37856
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.309472
MA0163.10.253219
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.0626799
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105135.978360719368610.007153832484726970.0297238666005888
E2F1#186944.907389214879320.001724022357361790.010644704166746
E2F4#1874412.66806031528443.88145892637771e-050.000726349558881852
EGR1#195844.988179094810140.001615011500076050.010139476168106
ELF1#199744.258097958807540.003041525565781240.0160788564772538
ELK4#2005312.1767612438510.0008912632577620610.0066364354325832
ETS1#211349.728760922202340.0001115955317418140.00154472176800309
GABPB1#255347.067683836182170.0004006876864423170.00390112997896421
GATA3#2625213.6182581786030.00769665208093340.0316905439259059
HEY1#2346244.040111043105710.00375304636917980.018587083163447
IRF1#365947.63716375356390.0002938853996185490.0030729973218624
POU2F2#545249.106124057742520.000145395665174930.00188305777222278
RFX5#599339.035933120396320.002144561191324070.0123839337753342
SIN3A#2594245.408884726815140.001168172384885160.00795687443455428
SIX5#147912312.81503651659420.0007664471136930380.00601540317930317
SMARCC2#6601247.07768721344880.0006669282967095870.00545060837155118
SP1#666745.69838137814090.0009482606065333980.00683757176786396
SP2#6668319.61514787038350.0002171004269245340.00248588438631415
TAF1#687243.343046285745290.008005664898701650.032190022189709
TBP#690843.706770687096390.005296377814784350.0243946373802982
YY1#752844.911170749853860.00171871838055440.0106744308365082
ZNF143#7702310.12565741417090.001534861610688180.00976482771434353
ZNF263#1012736.166381227758010.006539814347975980.0279682105846715



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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