MCL coexpression mm9:1972

Phase1 CAGE Peaks

	Short description
Mm9::chr11:53244281..53244340,-	p1@Uqcrq
Mm9::chr2:174289540..174289551,-	p2@Atp5e
Mm9::chr4:40226373..40226414,-	p1@Ndufb6
Mm9::chr6:125142195..125142228,+	p1@Mrpl51

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005739	mitochondrion	0.000878702121549544
GO:0044429	mitochondrial part	0.00139034920464052
GO:0044455	mitochondrial membrane part	0.00155129181801757
GO:0015078	hydrogen ion transmembrane transporter activity	0.0044695623510328
GO:0015077	monovalent inorganic cation transmembrane transporter activity	0.0044695623510328
GO:0022890	inorganic cation transmembrane transporter activity	0.00693727815077478
GO:0005753	mitochondrial proton-transporting ATP synthase complex	0.0128646546783533
GO:0044444	cytoplasmic part	0.0134689523553146
GO:0005743	mitochondrial inner membrane	0.0134941987268441
GO:0019866	organelle inner membrane	0.0134941987268441
GO:0031966	mitochondrial membrane	0.0134941987268441
GO:0005740	mitochondrial envelope	0.0138508279464587
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	0.0138508279464587
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	0.0150038303946409
GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	0.0177202870675471
GO:0008121	ubiquinol-cytochrome-c reductase activity	0.0177202870675471
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	0.0177202870675471
GO:0031975	envelope	0.0177202870675471
GO:0031967	organelle envelope	0.0177202870675471
GO:0006091	generation of precursor metabolites and energy	0.0199794080386367
GO:0008324	cation transmembrane transporter activity	0.0235762164430165
GO:0045259	proton-transporting ATP synthase complex	0.0245295343418053
GO:0031090	organelle membrane	0.0273003996548574
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	0.0273003996548574
GO:0005746	mitochondrial respiratory chain	0.0273003996548574
GO:0015075	ion transmembrane transporter activity	0.0273003996548574
GO:0015985	energy coupled proton transport, down electrochemical gradient	0.0273003996548574
GO:0015986	ATP synthesis coupled proton transport	0.0273003996548574
GO:0044446	intracellular organelle part	0.0273003996548574
GO:0005737	cytoplasm	0.0273003996548574
GO:0044422	organelle part	0.0273003996548574
GO:0006754	ATP biosynthetic process	0.0273003996548574
GO:0006753	nucleoside phosphate metabolic process	0.0273003996548574
GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	0.0273003996548574
GO:0016469	proton-transporting two-sector ATPase complex	0.0273003996548574
GO:0046961	hydrogen ion transporting ATPase activity, rotational mechanism	0.0273003996548574
GO:0022891	substrate-specific transmembrane transporter activity	0.0273003996548574
GO:0000313	organellar ribosome	0.0273003996548574
GO:0046034	ATP metabolic process	0.0273003996548574
GO:0005761	mitochondrial ribosome	0.0273003996548574
GO:0016491	oxidoreductase activity	0.0273003996548574
GO:0009145	purine nucleoside triphosphate biosynthetic process	0.0273003996548574
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	0.0273003996548574
GO:0009201	ribonucleoside triphosphate biosynthetic process	0.0273003996548574
GO:0050136	NADH dehydrogenase (quinone) activity	0.0273003996548574
GO:0008137	NADH dehydrogenase (ubiquinone) activity	0.0273003996548574
GO:0003954	NADH dehydrogenase activity	0.0273003996548574
GO:0019829	cation-transporting ATPase activity	0.0273003996548574
GO:0009142	nucleoside triphosphate biosynthetic process	0.0273003996548574
GO:0009205	purine ribonucleoside triphosphate metabolic process	0.0273003996548574
GO:0016655	oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	0.0273003996548574
GO:0009199	ribonucleoside triphosphate metabolic process	0.0273003996548574
GO:0006119	oxidative phosphorylation	0.0273003996548574
GO:0009144	purine nucleoside triphosphate metabolic process	0.0273003996548574
GO:0031980	mitochondrial lumen	0.0273003996548574
GO:0015992	proton transport	0.0273003996548574
GO:0005759	mitochondrial matrix	0.0273003996548574
GO:0022857	transmembrane transporter activity	0.0273003996548574
GO:0006752	group transfer coenzyme metabolic process	0.0273003996548574
GO:0044249	cellular biosynthetic process	0.0273003996548574
GO:0009141	nucleoside triphosphate metabolic process	0.0274130749186557
GO:0009152	purine ribonucleotide biosynthetic process	0.0274130749186557
GO:0006818	hydrogen transport	0.0274130749186557
GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	0.0274130749186557
GO:0009260	ribonucleotide biosynthetic process	0.0274130749186557
GO:0043231	intracellular membrane-bound organelle	0.0274130749186557
GO:0043227	membrane-bound organelle	0.0274130749186557
GO:0022892	substrate-specific transporter activity	0.0277030697338808
GO:0009150	purine ribonucleotide metabolic process	0.0277030697338808
GO:0006164	purine nucleotide biosynthetic process	0.0277317077783534
GO:0016651	oxidoreductase activity, acting on NADH or NADPH	0.0277594701017158
GO:0009259	ribonucleotide metabolic process	0.0290233988590009
GO:0006163	purine nucleotide metabolic process	0.0302516260249248
GO:0042625	ATPase activity, coupled to transmembrane movement of ions	0.0326469894789926
GO:0009108	coenzyme biosynthetic process	0.0330016178530571
GO:0051188	cofactor biosynthetic process	0.0376280457883119
GO:0009058	biosynthetic process	0.0381003043476087
GO:0043229	intracellular organelle	0.0381807149439813
GO:0043226	organelle	0.0381807149439813
GO:0043492	ATPase activity, coupled to movement of substances	0.0420710765210653
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	0.0420710765210653
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.0420710765210653
GO:0009165	nucleotide biosynthetic process	0.0436924945731703
GO:0015399	primary active transmembrane transporter activity	0.0447405944058265
GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	0.0447405944058265
GO:0009055	electron carrier activity	0.0469532093348615

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
epithelial cell	3.98e-07	25

Uber Anatomy

Ontology term	p-value	n
mucosa	3.13e-10	15
intestinal mucosa	4.22e-09	13
anatomical wall	4.22e-09	13
wall of intestine	4.22e-09	13
gastrointestinal system mucosa	4.22e-09	13
intestine	7.55e-09	31
epithelial tube	2.13e-08	47

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
MA0003.1	0.142214
MA0004.1	0.6888
MA0006.1	0.497533
MA0007.1	0.672186
MA0009.1	1.15569
MA0014.1	0.581929
MA0017.1	0.528196
MA0019.1	0.964875
MA0024.1	1.11019
MA0025.1	1.39562
MA0027.1	2.81824
MA0028.1	2.19266
MA0029.1	1.08753
MA0030.1	1.09438
MA0031.1	1.05719
MA0038.1	0.846479
MA0040.1	1.16866
MA0041.1	0.604221
MA0042.1	0.589368
MA0043.1	1.25564
MA0046.1	1.1929
MA0048.1	0.735223
MA0050.1	0.731539
MA0051.1	0.856094
MA0052.1	1.17701
MA0055.1	1.28762
MA0056.1	0
MA0057.1	0.701847
MA0058.1	0.581673
MA0059.1	0.59559
MA0060.1	1.04037
MA0061.1	0.438628
MA0063.1	0
MA0066.1	0.834648
MA0067.1	1.50873
MA0068.1	0.713436
MA0069.1	1.17737
MA0070.1	1.16732
MA0071.1	0.73062
MA0072.1	1.15853
MA0073.1	0.00221226
MA0074.1	0.795862
MA0076.1	4.59949
MA0077.1	1.13603
MA0078.1	0.891476
MA0081.1	1.5065
MA0083.1	1.25482
MA0084.1	1.84013
MA0087.1	1.21037
MA0088.1	0.201215
MA0089.1	0
MA0090.1	0.650768
MA0091.1	0.703314
MA0092.1	0.651119
MA0093.1	1.29026
MA0095.1	0
MA0098.1	0
MA0100.1	0.783305
MA0101.1	0.605676
MA0103.1	0.540576
MA0105.1	0.313353
MA0106.1	0.899777
MA0107.1	0.533522
MA0108.2	0.989014
MA0109.1	0
MA0111.1	0.666525
MA0113.1	0.869608
MA0114.1	0.43587
MA0115.1	1.25852
MA0116.1	1.24367
MA0117.1	1.22527
MA0119.1	0.606338
MA0122.1	1.24573
MA0124.1	1.45461
MA0125.1	1.37907
MA0130.1	0
MA0131.1	0.960068
MA0132.1	0
MA0133.1	0
MA0135.1	1.29308
MA0136.1	0.817395
MA0139.1	0.365453
MA0140.1	0.78318
MA0141.1	1.38335
MA0142.1	1.04199
MA0143.1	0.887119
MA0144.1	1.11951
MA0145.1	0.608454
MA0146.1	1.5929
MA0147.1	1.15069
MA0148.1	0.706718
MA0149.1	0.611881
MA0062.2	3.24307
MA0035.2	0.788288
MA0039.2	2.41467
MA0138.2	0.951653
MA0002.2	0.368961
MA0137.2	1.37638
MA0104.2	1.0034
MA0047.2	0.845655
MA0112.2	0.211985
MA0065.2	0.212467
MA0150.1	0.67206
MA0151.1	0
MA0152.1	0.84577
MA0153.1	1.31015
MA0154.1	0.728853
MA0155.1	1.8891
MA0156.1	1.35382
MA0157.1	1.0083
MA0158.1	0
MA0159.1	1.1762
MA0160.1	0.71003
MA0161.1	0
MA0162.1	0.704935
MA0163.1	0.0996272
MA0164.1	0.817786
MA0080.2	0.534538
MA0018.2	0.828253
MA0099.2	0.944966
MA0079.2	0.300141
MA0102.2	1.8929
MA0258.1	0.419871
MA0259.1	0.441366
MA0442.1	0