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{{CL
{{CL
|id=CL:0000129
|alt_id=
|name=microglial cell
|namespace=cell
|def="A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275]
|xref=BTO:0000078;;BTO:0000962;;FMA:54539;;FMA:54540
|is_a=CL:0000243;;CL:0000878
|synonym="brain macrophage" BROAD [];;"brain-resident macrophage" EXACT [];;"hortega cells" EXACT [http://www.copewithcytokines.de/];;"MF.microglia.CNS" RELATED [];;"microglia" EXACT [];;"microgliocyte" EXACT [http://www.copewithcytokines.de/]
|comment=Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD19-negative, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.
|comment=Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD19-negative, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275]
|subset=
|adjacent_to=
|derives_from=
|derives_from=
|develops_from=CL:0002453
|develops_from=CL:0002453
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000129
|is_a=CL:0000243 ;;CL:0000878
|is_obsolete=
|located_in=
|located_in=
|name=microglial cell
|namespace=FANTOM
|obo_creation_date=
|part_of=UBERON:0001017
|part_of=UBERON:0001017
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|subset=
|synonym="brain macrophage" BROAD [];;"brain-resident macrophage" EXACT [];;"hortega cells" EXACT [http://www.copewithcytokines.de/];;"MF.microglia.CNS" RELATED [];;"microglia" EXACT [];;"microgliocyte" EXACT [http://www.copewithcytokines.de/]
|union_of=
|xref=BTO:0000078;;BTO:0000962;;FMA:54539;;FMA:54540
}}
}}

Latest revision as of 16:30, 12 September 2014

Name:microglial cell
Namespace:FANTOM
Definition:"A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275]
Xrefs:
links:

BTO:0000078
BTO:0000962
FMA:54539

FMA:54540
Synonyms: "brain macrophage" BROAD []
"brain-resident macrophage" EXACT []
"hortega cells" EXACT [1]
"MF.microglia.CNS" RELATED []
"microglia" EXACT []
"microgliocyte" EXACT [2]
Comments:Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD19-negative, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000243(glial cell (sensu Vertebrata)),CL:0000878(central nervous system macrophage)
develops_from:CL:0002453(oligodendrocyte precursor cell)
part_of:UBERON:0001017(central nervous system)



Children


is a:FF:0000100 (microglial cell)
derives from:FF:0000113 (mouse microglial cell sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000129 (microglial cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.87e-86FFCP PHASE2:Mm9::chr12:112646729..112646768,+#_830011477e36205b441e1057fa5cfac0p@chr12:112646729..112646768, +
1.87e-86FFCP PHASE2:Mm9::chr8:113227136..113227143,+#_830011477e36205b441e1057fa5cfac0p@chr8:113227136..113227143, +
1.87e-86FFCP PHASE1:Mm9::chr8:113227136..113227143,+#_830011477e36205b441e1057fa5cfac0p@chr8:113227136..113227143, +
1.87e-86FFCP PHASE1:Mm9::chr12:112646729..112646768,+#_830011477e36205b441e1057fa5cfac0p@chr12:112646729..112646768, +
1.68e-58FFCP PHASE1:Mm9::chr10:75403311..75403323,-#_28ea8393181c10719994f4a75930ce42p3@ENSMUST00000059658, p3@uc007fts.1
1.68e-58FFCP PHASE2:Mm9::chr10:75403311..75403323,-#_28ea8393181c10719994f4a75930ce42p3@ENSMUST00000059658, p3@uc007fts.1
1.66e-44FFCP PHASE1:Mm9::chr10:59862550..59862553,+#_d7d647ed8914ba0368313c83290ea8f2p3@Gm17455
1.66e-44FFCP PHASE1:Mm9::chr11:102749101..102749112,-#_d7d647ed8914ba0368313c83290ea8f2p@chr11:102749101..102749112, -
1.66e-44FFCP PHASE2:Mm9::chr10:59862550..59862553,+#_d7d647ed8914ba0368313c83290ea8f2p3@Gm17455
1.66e-44FFCP PHASE2:Mm9::chr11:102749101..102749112,-#_d7d647ed8914ba0368313c83290ea8f2p@chr11:102749101..102749112, -
1.66e-44FFCP PHASE2:Mm9::chr15:88808274..88808289,-#_d7d647ed8914ba0368313c83290ea8f2p@chr15:88808274..88808289, -
1.66e-44FFCP PHASE1:Mm9::chr15:88808274..88808289,-#_d7d647ed8914ba0368313c83290ea8f2p@chr15:88808274..88808289, -
2.75e-44FFCP PHASE2:Mm9::chr4:135525988..135526004,-#_789dc8a1cafa9b3433ad6ae1881dbe8bp@chr4:135525988..135526004, -
2.75e-44FFCP PHASE1:Mm9::chr4:135525988..135526004,-#_789dc8a1cafa9b3433ad6ae1881dbe8bp@chr4:135525988..135526004, -
4.55e-44FFCP PHASE2:Mm9::chr17:48934179..48934192,-#_c223dd1033647d17eb528d81bc0add21p@chr17:48934179..48934192, -
4.55e-44FFCP PHASE1:Mm9::chr17:48934179..48934192,-#_c223dd1033647d17eb528d81bc0add21p@chr17:48934179..48934192, -
7.52e-44FFCP PHASE2:Mm9::chr11:94506584..94506586,+#_5b9440d6aab0e4294ad2b8cdf5a9f300p@chr11:94506584..94506586, +
7.52e-44FFCP PHASE1:Mm9::chr11:94506584..94506586,+#_5b9440d6aab0e4294ad2b8cdf5a9f300p@chr11:94506584..94506586, +
4.23e-36FFCP PHASE2:Mm9::chr11:102749254..102749263,-#_84e5c698051da5e29039fbea880bf1a2p@chr11:102749254..102749263, -
4.23e-36FFCP PHASE1:Mm9::chr11:102749254..102749263,-#_84e5c698051da5e29039fbea880bf1a2p@chr11:102749254..102749263, -
2.13e-35FFCP PHASE1:Mm9::chr16:15895800..15895814,-#_597f78a11b1bcb98437d407aa61c274cp@chr16:15895800..15895814, -
2.13e-35FFCP PHASE2:Mm9::chr16:15895800..15895814,-#_597f78a11b1bcb98437d407aa61c274cp@chr16:15895800..15895814, -
4.75e-35FFCP PHASE2:Mm9::chr11:75244815..75244826,-#_a747405c4367765b2716e96e6c2870cap@chr11:75244815..75244826, -
4.75e-35FFCP PHASE1:Mm9::chr11:75244815..75244826,-#_a747405c4367765b2716e96e6c2870cap@chr11:75244815..75244826, -
1.73e-30FFCP PHASE2:Mm9::chr11:45567111..45567116,-#_15eeb93f8b2c3b8fd2ed55553b7b2e21p@chr11:45567111..45567116, -
1.73e-30FFCP PHASE1:Mm9::chr11:45567111..45567116,-#_15eeb93f8b2c3b8fd2ed55553b7b2e21p@chr11:45567111..45567116, -
3.41e-30FFCP PHASE2:Mm9::chr17:35822365..35822376,-#_ac5d173e60a8dd4e71f23e36522464a8p@chr17:35822365..35822376, -
3.41e-30FFCP PHASE2:Mm9::chr9:103595089..103595100,-#_ac5d173e60a8dd4e71f23e36522464a8p4@Tmem108
3.41e-30FFCP PHASE1:Mm9::chr9:103595089..103595100,-#_ac5d173e60a8dd4e71f23e36522464a8p4@Tmem108
3.41e-30FFCP PHASE1:Mm9::chr17:35822365..35822376,-#_ac5d173e60a8dd4e71f23e36522464a8p@chr17:35822365..35822376, -
4.77e-30FFCP PHASE2:Mm9::chr11:102754448..102754459,-#_d07d88075d714adae8b5a562bc7e142dp@chr11:102754448..102754459, -
4.77e-30FFCP PHASE1:Mm9::chr11:102754448..102754459,-#_d07d88075d714adae8b5a562bc7e142dp@chr11:102754448..102754459, -
6.69e-30FFCP PHASE1:Mm9::chr7:56865136..56865147,+#_2fdb027034483b4be917c37eb2f5673bp@chr7:56865136..56865147, +
6.69e-30FFCP PHASE2:Mm9::chr7:56865136..56865147,+#_2fdb027034483b4be917c37eb2f5673bp@chr7:56865136..56865147, +
1.31e-29FFCP PHASE1:Mm9::chr4:136452258..136452269,-#_7510679e9b1beeb9c5564a2fad398056p@chr4:136452258..136452269, -
1.31e-29FFCP PHASE2:Mm9::chr4:136452258..136452269,-#_7510679e9b1beeb9c5564a2fad398056p@chr4:136452258..136452269, -
1.78e-26FFCP PHASE2:Mm9::chr11:102754827..102754845,-#_cb16ab5f71908387d8318199614e5b94p@chr11:102754827..102754845, -
1.78e-26FFCP PHASE1:Mm9::chr11:102754827..102754845,-#_cb16ab5f71908387d8318199614e5b94p@chr11:102754827..102754845, -
2.38e-26FFCP PHASE2:Mm9::chr11:102750776..102750792,-#_40ff247d9f82cfbbdd1273d2e4299277p@chr11:102750776..102750792, -
2.38e-26FFCP PHASE1:Mm9::chr11:102750776..102750792,-#_40ff247d9f82cfbbdd1273d2e4299277p@chr11:102750776..102750792, -
4.27e-26FFCP PHASE2:Mm9::chr11:102807862..102807882,-#_92cb1c5120b11059ddf717e0dac5b08bp4@C1ql1
4.27e-26FFCP PHASE1:Mm9::chr11:102807862..102807882,-#_92cb1c5120b11059ddf717e0dac5b08bp4@C1ql1
7.61e-26FFCP PHASE1:Mm9::chr11:32036107..32036145,-#_36042962e11a2cb1dccb6c25798cf3bbp@chr11:32036107..32036145, -
7.61e-26FFCP PHASE2:Mm9::chr11:32036107..32036145,-#_36042962e11a2cb1dccb6c25798cf3bbp@chr11:32036107..32036145, -
1.02e-25FFCP PHASE2:Mm9::chr7:31844871..31844895,+#_a0bd3a20f343bfbf9ce9f59bc6268723p9@Lgi4
1.02e-25FFCP PHASE1:Mm9::chr7:31844871..31844895,+#_a0bd3a20f343bfbf9ce9f59bc6268723p9@Lgi4
1.35e-25FFCP PHASE2:Mm9::chr1:72873192..72873206,+#_5512d0cfe5fd816038f4b4cf5812cd17p@chr1:72873192..72873206, +
1.35e-25FFCP PHASE1:Mm9::chr8:28132545..28132551,+#_5512d0cfe5fd816038f4b4cf5812cd17p@chr8:28132545..28132551, +
1.35e-25FFCP PHASE1:Mm9::chr1:72873192..72873206,+#_5512d0cfe5fd816038f4b4cf5812cd17p@chr1:72873192..72873206, +
1.35e-25FFCP PHASE1:Mm9::chr8:125951458..125951466,-#_5512d0cfe5fd816038f4b4cf5812cd17p@chr8:125951458..125951466, -
1.35e-25FFCP PHASE2:Mm9::chr8:125951458..125951466,-#_5512d0cfe5fd816038f4b4cf5812cd17p@chr8:125951458..125951466, -
1.35e-25FFCP PHASE2:Mm9::chr8:28132545..28132551,+#_5512d0cfe5fd816038f4b4cf5812cd17p@chr8:28132545..28132551, +
1.8e-25FFCP PHASE1:Mm9::chr1:34754390..34754396,+#_e07a33bc9870f15df3e7295ff29219d3p@chr1:34754390..34754396, +
1.8e-25FFCP PHASE2:Mm9::chr1:174128785..174128802,+#_e07a33bc9870f15df3e7295ff29219d3p@chr1:174128785..174128802, +
1.8e-25FFCP PHASE1:Mm9::chr1:174128785..174128802,+#_e07a33bc9870f15df3e7295ff29219d3p@chr1:174128785..174128802, +
1.8e-25FFCP PHASE2:Mm9::chr1:34754390..34754396,+#_e07a33bc9870f15df3e7295ff29219d3p@chr1:34754390..34754396, +
3.19e-25FFCP PHASE2:Mm9::chr8:125956332..125956339,-#_0ae253533b8a3b95bec135e8925edee9p@chr8:125956332..125956339, -
3.19e-25FFCP PHASE2:Mm9::chr8:125951545..125951559,-#_0ae253533b8a3b95bec135e8925edee9p@chr8:125951545..125951559, -
3.19e-25FFCP PHASE1:Mm9::chr8:125952002..125952012,-#_0ae253533b8a3b95bec135e8925edee9p@chr8:125952002..125952012, -
3.19e-25FFCP PHASE1:Mm9::chr8:125952310..125952320,+#_0ae253533b8a3b95bec135e8925edee9p@chr8:125952310..125952320, +
3.19e-25FFCP PHASE1:Mm9::chr8:125956332..125956339,-#_0ae253533b8a3b95bec135e8925edee9p@chr8:125956332..125956339, -
3.19e-25FFCP PHASE1:Mm9::chr8:125951545..125951559,-#_0ae253533b8a3b95bec135e8925edee9p@chr8:125951545..125951559, -
3.19e-25FFCP PHASE2:Mm9::chr8:125952002..125952012,-#_0ae253533b8a3b95bec135e8925edee9p@chr8:125952002..125952012, -
3.19e-25FFCP PHASE2:Mm9::chr8:125952310..125952320,+#_0ae253533b8a3b95bec135e8925edee9p@chr8:125952310..125952320, +
5.1e-23FFCP PHASE2:Mm9::chr11:69414608..69414617,-#_3c22ef516fd677815646f6cf8d91a1a9p@chr11:69414608..69414617, -
5.1e-23FFCP PHASE1:Mm9::chr11:69414608..69414617,-#_3c22ef516fd677815646f6cf8d91a1a9p@chr11:69414608..69414617, -
8.47e-23FFCP PHASE1:Mm9::chr3:87067576..87067584,-#_98615a4c24dcb3f5a76f622bddd00996p3@Fcrls
8.47e-23FFCP PHASE2:Mm9::chr3:87067576..87067584,-#_98615a4c24dcb3f5a76f622bddd00996p3@Fcrls
8.47e-23FFCP PHASE1:Mm9::chr3:87067625..87067636,-#_98615a4c24dcb3f5a76f622bddd00996p2@Fcrls
8.47e-23FFCP PHASE1:Mm9::chr4:136452194..136452198,-#_98615a4c24dcb3f5a76f622bddd00996p@chr4:136452194..136452198, -
8.47e-23FFCP PHASE2:Mm9::chr4:136452194..136452198,-#_98615a4c24dcb3f5a76f622bddd00996p@chr4:136452194..136452198, -
8.47e-23FFCP PHASE1:Mm9::chr4:136436677..136436688,-#_98615a4c24dcb3f5a76f622bddd00996p@chr4:136436677..136436688, -
8.47e-23FFCP PHASE2:Mm9::chr4:136436677..136436688,-#_98615a4c24dcb3f5a76f622bddd00996p@chr4:136436677..136436688, -
8.47e-23FFCP PHASE2:Mm9::chr3:87067625..87067636,-#_98615a4c24dcb3f5a76f622bddd00996p2@Fcrls
9.5e-23FFCP PHASE1:Mm9::chr8:87232404..87232415,-#_9f0301db9f49f031e6f463c0207de1d8p22@Nfix
9.5e-23FFCP PHASE2:Mm9::chr8:87232404..87232415,-#_9f0301db9f49f031e6f463c0207de1d8p22@Nfix
9.5e-23FFCP PHASE1:Mm9::chr15:103345675..103345685,+#_9f0301db9f49f031e6f463c0207de1d8p10@Pde1b
9.5e-23FFCP PHASE1:Mm9::chr17:24856898..24856901,+#_9f0301db9f49f031e6f463c0207de1d8p3@Gm10420, p3@Gm5786, p3@Gm8842, p3@Rps2
9.5e-23FFCP PHASE2:Mm9::chr8:96678044..96678046,-#_9f0301db9f49f031e6f463c0207de1d8p@chr8:96678044..96678046, -
9.5e-23FFCP PHASE2:Mm9::chr9:106363021..106363029,+#_9f0301db9f49f031e6f463c0207de1d8p11@Pcbp4
9.5e-23FFCP PHASE2:Mm9::chr5:123689685..123689727,+#_9f0301db9f49f031e6f463c0207de1d8p@chr5:123689685..123689727, +
9.5e-23FFCP PHASE2:Mm9::chr19:6497758..6497764,+#_9f0301db9f49f031e6f463c0207de1d8p17@Nrxn2
9.5e-23FFCP PHASE2:Mm9::chr17:24856898..24856901,+#_9f0301db9f49f031e6f463c0207de1d8p3@Gm10420, p3@Gm5786, p3@Gm8842, p3@Rps2
9.5e-23FFCP PHASE1:Mm9::chr19:6497758..6497764,+#_9f0301db9f49f031e6f463c0207de1d8p17@Nrxn2
9.5e-23FFCP PHASE2:Mm9::chr15:103345675..103345685,+#_9f0301db9f49f031e6f463c0207de1d8p10@Pde1b
9.5e-23FFCP PHASE1:Mm9::chr8:96678044..96678046,-#_9f0301db9f49f031e6f463c0207de1d8p@chr8:96678044..96678046, -
9.5e-23FFCP PHASE1:Mm9::chr5:123689685..123689727,+#_9f0301db9f49f031e6f463c0207de1d8p@chr5:123689685..123689727, +
9.5e-23FFCP PHASE1:Mm9::chr9:106363021..106363029,+#_9f0301db9f49f031e6f463c0207de1d8p11@Pcbp4
1.4e-22FFCP PHASE1:Mm9::chr8:11006242..11006246,-#_e143c7b16aeaaa9a7892ef783d7f18ecp@chr8:11006242..11006246, -
1.4e-22FFCP PHASE2:Mm9::chr8:11006242..11006246,-#_e143c7b16aeaaa9a7892ef783d7f18ecp@chr8:11006242..11006246, -
1.8e-22FFCP PHASE1:Mm9::chr19:8788816..8788826,-#_4921b90938d728205d57b23d6acc96c4p14@Slc3a2
1.8e-22FFCP PHASE2:Mm9::chr19:8788816..8788826,-#_4921b90938d728205d57b23d6acc96c4p14@Slc3a2
2.32e-22FFCP PHASE1:Mm9::chr6:48997958..48997979,-#_6df47730ba1dce20c41605653c38d7dbp@chr6:48997958..48997979, -
2.32e-22FFCP PHASE1:Mm9::chr11:69478859..69478867,-#_6df47730ba1dce20c41605653c38d7dbp@chr11:69478859..69478867, -
2.32e-22FFCP PHASE2:Mm9::chr11:69478859..69478867,-#_6df47730ba1dce20c41605653c38d7dbp@chr11:69478859..69478867, -
2.32e-22FFCP PHASE2:Mm9::chr6:48997958..48997979,-#_6df47730ba1dce20c41605653c38d7dbp@chr6:48997958..48997979, -
2.97e-22FFCP PHASE2:Mm9::chr1:173164773..173164781,-#_5431e08ccc95008716559dc8eb96b4cfp3@Fcer1g
2.97e-22FFCP PHASE1:Mm9::chr1:173164773..173164781,-#_5431e08ccc95008716559dc8eb96b4cfp3@Fcer1g
4.07e-21FFCP PHASE2:Mm9::chr11:102749020..102749031,-#_b9dcf1da762ed0fb51bbab08c109366dp@chr11:102749020..102749031, -
4.07e-21FFCP PHASE1:Mm9::chr11:102749020..102749031,-#_b9dcf1da762ed0fb51bbab08c109366dp@chr11:102749020..102749031, -

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