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{{Coexpression_clusters
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|full_id=C1877_kidney_cervical_salivary_parotid_submaxillary_epididymis_thyroid
|id=C1877
|ontology_enrichment_celltype=CL:0002623!3.26e-08!3
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0001044!1.59e-16!6;UBERON:0003293!1.59e-16!6;UBERON:0003294!1.59e-16!6;UBERON:0010047!1.59e-16!6;UBERON:0000167!1.59e-16!6;UBERON:0007023!1.91e-16!115;UBERON:0000161!7.84e-14!35;UBERON:0004119!5.17e-13!169;UBERON:0000925!5.17e-13!169;UBERON:0006595!5.17e-13!169;UBERON:0003408!1.15e-12!10;UBERON:0001007!4.42e-12!155;UBERON:0001555!4.42e-12!155;UBERON:0007026!4.42e-12!155;UBERON:0004921!7.45e-12!129;UBERON:0004185!7.45e-12!129;UBERON:0000166!3.76e-11!21;UBERON:0000078!5.48e-11!18;UBERON:0001004!6.39e-10!72;UBERON:0006947!7.07e-10!3;UBERON:0004054!7.07e-10!3;UBERON:0000077!4.88e-09!130;UBERON:0005156!5.45e-08!59;UBERON:0000990!5.45e-08!59;UBERON:0000464!5.66e-08!104;UBERON:0000165!7.59e-08!28;UBERON:0000930!7.59e-08!28;UBERON:0004175!1.31e-07!25;UBERON:0005904!1.76e-07!4;UBERON:0001829!3.04e-07!2;UBERON:0000341!5.60e-07!2;UBERON:0002530!6.37e-07!59;UBERON:0003101!6.50e-07!22;UBERON:0000079!6.50e-07!22;UBERON:0003127!7.05e-07!2;UBERON:0003133!8.33e-07!48
}}

Latest revision as of 11:54, 17 September 2013


Full id: C1877_kidney_cervical_salivary_parotid_submaxillary_epididymis_thyroid



Phase1 CAGE Peaks

Hg19::chr21:31588318..31588321,-p5@CLDN8
Hg19::chr21:31588338..31588357,-p1@CLDN8
Hg19::chr21:31588358..31588363,-p4@CLDN8
Hg19::chr21:31588365..31588398,-p2@CLDN8
Hg19::chr21:31588401..31588433,-p3@CLDN8


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism3.58e-17114
male genital duct1.17e-163
internal male genitalia1.17e-163
duct of male reproductive system1.27e-124
major salivary gland4.39e-122
throat7.93e-122
male reproductive organ1.13e-1111
open tracheal system trachea4.05e-112
male organism1.26e-1022
male reproductive system1.26e-1022
orifice4.70e-1036
saliva-secreting gland8.19e-096
gland of oral region8.19e-096
gland of foregut8.19e-096
oral gland8.19e-096
oral cavity8.19e-096
subdivision of digestive tract1.16e-08118
digestive system1.78e-08145
digestive tract1.78e-08145
primitive gut1.78e-08145
endoderm-derived structure2.60e-08160
endoderm2.60e-08160
presumptive endoderm2.60e-08160
oral opening5.60e-0822
anatomical space1.07e-0795
respiratory system1.50e-0774
tongue1.91e-073
gustatory system1.91e-073
future tongue1.91e-073
foregut2.93e-0787
internal genitalia4.17e-0725
reproductive structure5.39e-0759
reproductive system5.39e-0759
epididymis6.23e-071
submandibular gland6.59e-071
submandibular gland primordium6.59e-071
parotid gland7.77e-071
cheek7.77e-071
parotid gland primordium7.77e-071
organism subdivision8.37e-07264


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00991994
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.0418333
MA0017.12.14806
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.18.83844
MA0031.15.10074
MA0038.10.736268
MA0040.13.83798
MA0041.13.838
MA0042.11.48719
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.0853006
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.16.36441
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.00220137
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.11.96988
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.14.48067
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.13.47082
MA0145.10.868598
MA0146.10.0359558
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.777733
MA0035.20.691506
MA0039.20.0118463
MA0138.20.837782
MA0002.20.30855
MA0137.23.09133
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.10.130813
MA0156.10.480289
MA0157.13.38501
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.0439995
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.23.83292e-05
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOXA1#3169511.08141974938555.98116883436141e-060.000179090393317624
GATA3#2625527.2365163572066.66232132211975e-084.06428841449103e-06



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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