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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,

Latest revision as of 11:33, 17 September 2013


Full id: C902_anaplastic_skeletal_tongue_liver_umbilical_pituitary_diaphragm



Phase1 CAGE Peaks

Hg19::chr14:101193191..101193241,+p1@DLK1
Hg19::chr14:101193246..101193264,+p2@DLK1
Hg19::chr14:101193271..101193288,+p3@DLK1
Hg19::chr14:101193325..101193336,+p4@DLK1
Hg19::chr14:101194733..101194743,+p@chr14:101194733..101194743
+
Hg19::chr14:101200589..101200608,+p@chr14:101200589..101200608
+
Hg19::chr14:101200645..101200656,+p@chr14:101200645..101200656
+
Hg19::chr14:101201250..101201259,+p@chr14:101201250..101201259
+
Hg19::chr20:57429075..57429096,+p41@GNAS


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0031852mu-type opioid receptor binding0.00170728835511598
GO:0031628opioid receptor binding0.00170728835511598
GO:0000267cell fraction0.013614717070241
GO:0042383sarcolemma0.013655291407137
GO:0007189G-protein signaling, adenylate cyclase activating pathway0.0210453992747378
GO:0005834heterotrimeric G-protein complex0.0210453992747378
GO:0019897extrinsic to plasma membrane0.024308806425694
GO:0009306protein secretion0.024308806425694
GO:0007565female pregnancy0.0269720135633154
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messenger0.0269720135633154
GO:0019933cAMP-mediated signaling0.0269720135633154
GO:0001664G-protein-coupled receptor binding0.0277224307614203
GO:0019898extrinsic to membrane0.0277224307614203
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messenger0.0277224307614203
GO:0019935cyclic-nucleotide-mediated signaling0.0277224307614203
GO:0005625soluble fraction0.0497669265942867



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
embryonic stem cell8.61e-165
Uber Anatomy
Ontology termp-valuen
pituitary gland7.14e-082
endocrine gland3.69e-0735
male reproductive organ9.76e-0711


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.0633
MA0004.10.415381
MA0006.10.733408
MA0007.10.397529
MA0009.10.870971
MA0014.14.93087
MA0017.10.301634
MA0019.10.558663
MA0024.10.766783
MA0025.11.00397
MA0027.12.48103
MA0028.10.280275
MA0029.10.785955
MA0030.10.774581
MA0031.10.710608
MA0038.10.514558
MA0040.10.791764
MA0041.10.433167
MA0042.10.402577
MA0043.10.871285
MA0046.10.860127
MA0048.10.264106
MA0050.10.403421
MA0051.10.510444
MA0052.10.795605
MA0055.10.693769
MA0056.10
MA0057.13.14271
MA0058.10.86817
MA0059.11.55919
MA0060.10.162248
MA0061.10.851955
MA0063.10
MA0066.10.514973
MA0067.11.18766
MA0068.10.109867
MA0069.11.99244
MA0070.10.845142
MA0071.10.47692
MA0072.10.840664
MA0073.12.36016
MA0074.11.27017
MA0076.10.339975
MA0077.10.832987
MA0078.10.607575
MA0081.10.324031
MA0083.10.878452
MA0084.11.37471
MA0087.10.838229
MA0088.11.4402
MA0089.10
MA0090.10.353576
MA0091.10.417885
MA0092.10.381858
MA0093.10.26836
MA0095.10
MA0098.10
MA0100.10.528088
MA0101.10.746654
MA0103.11.31682
MA0105.10.229733
MA0106.10.554855
MA0107.10.205358
MA0108.20.707575
MA0109.10
MA0111.10.959847
MA0113.10.57094
MA0114.10.200901
MA0115.11.11137
MA0116.11.77226
MA0117.10.908433
MA0119.10.308914
MA0122.10.934245
MA0124.11.06995
MA0125.10.986127
MA0130.10
MA0131.10.625452
MA0132.10
MA0133.10
MA0135.10.90122
MA0136.10.521435
MA0139.10.129876
MA0140.10.474342
MA0141.10.322254
MA0142.10.679161
MA0143.10.571113
MA0144.10.1885
MA0145.11.53859
MA0146.11.3662
MA0147.12.52411
MA0148.10.439278
MA0149.10.464973
MA0062.20.421263
MA0035.20.473658
MA0039.21.17223
MA0138.20.608783
MA0002.20.46405
MA0137.20.28622
MA0104.23.66848
MA0047.20.542971
MA0112.20.378721
MA0065.20.182082
MA0150.10.34802
MA0151.10
MA0152.10.480711
MA0153.10.969315
MA0154.10.225151
MA0155.12.45061
MA0156.10.288314
MA0157.10.652111
MA0158.10
MA0159.10.212043
MA0160.10.453945
MA0161.10
MA0162.16.388
MA0163.16.94839
MA0164.10.583138
MA0080.20.268439
MA0018.20.556211
MA0099.20.481058
MA0079.25.96884
MA0102.21.41188
MA0258.10.180288
MA0259.10.624802
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
REST#597844.288901651612450.009457025945962830.0356667027578511



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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