Coexpression cluster:C48: Difference between revisions
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Latest revision as of 10:17, 17 September 2013
Full id: C48_smooth_bladder_esophagus_colon_penis_aorta_uterus
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
6.08435798160821e-10 | 1.925699301179e-07 | 7 | 116 | Vascular smooth muscle contraction (KEGG):04270 |
0.000278233574200777 | 0.0243662724756274 | 4 | 200 | Focal adhesion (KEGG):04510 |
0.000307946571571911 | 0.0243662724756274 | 3 | 83 | Hypertrophic cardiomyopathy (HCM) (KEGG):05410 |
0.000390723712999691 | 0.0274809011476449 | 3 | 90 | Dilated cardiomyopathy (KEGG):05414 |
4.53597997803346e-06 | 0.000717818831523795 | 5 | 155 | Myometrial Relaxation and Contraction Pathways (Wikipathways):WP289 |
2.73950528584538e-05 | 0.00346821369188025 | 3 | 37 | Sandbox Pathway (Wikipathways):WP4 |
0.000809666853976795 | 0.0465926471424828 | 5 | 466 | Hemostasis (Reactome):REACT_604 |
8.48701001558479e-15 | 5.37227733986517e-12 | 8 | 49 | Muscle contraction (Reactome):REACT_17044 |
0.00071233684154992 | 0.04509092207011 | 2 | 25 | IL-6 down reg. targets (Netpath):NetPath_18 |
1.5191901039302e-08 | 3.20549111929273e-06 | 8 | 288 | {ACTB,297} (Static Module):NA |
0.000108470732084703 | 0.0114436622349362 | 2 | 10 | {ROCK1,10} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0003012 | muscle system process | 7.17758044022067e-11 |
GO:0006936 | muscle contraction | 7.17758044022067e-11 |
GO:0005515 | protein binding | 1.99726356249025e-06 |
GO:0008092 | cytoskeletal protein binding | 3.41526941867738e-06 |
GO:0003779 | actin binding | 3.80060767866034e-06 |
GO:0006939 | smooth muscle contraction | 1.08494206137411e-05 |
GO:0005856 | cytoskeleton | 3.42412418529582e-05 |
GO:0005516 | calmodulin binding | 4.1542266842341e-05 |
GO:0015629 | actin cytoskeleton | 6.84472069691412e-05 |
GO:0030036 | actin cytoskeleton organization and biogenesis | 0.000516257005885001 |
GO:0030029 | actin filament-based process | 0.000553522573894243 |
GO:0006937 | regulation of muscle contraction | 0.000553522573894243 |
GO:0008307 | structural constituent of muscle | 0.000640254860897684 |
GO:0030016 | myofibril | 0.00120233532117574 |
GO:0044449 | contractile fiber part | 0.00162991093467295 |
GO:0043292 | contractile fiber | 0.00174897131744444 |
GO:0003008 | system process | 0.00174897131744444 |
GO:0005913 | cell-cell adherens junction | 0.00287580698797806 |
GO:0005737 | cytoplasm | 0.00562887267665167 |
GO:0005523 | tropomyosin binding | 0.006597028072221 |
GO:0031032 | actomyosin structure organization and biogenesis | 0.006597028072221 |
GO:0016528 | sarcoplasm | 0.00812148027606994 |
GO:0016529 | sarcoplasmic reticulum | 0.00812148027606994 |
GO:0043232 | intracellular non-membrane-bound organelle | 0.00812148027606994 |
GO:0043228 | non-membrane-bound organelle | 0.00812148027606994 |
GO:0051015 | actin filament binding | 0.015752241114304 |
GO:0006928 | cell motility | 0.015752241114304 |
GO:0051674 | localization of cell | 0.015752241114304 |
GO:0032501 | multicellular organismal process | 0.015752241114304 |
GO:0007517 | muscle development | 0.015752241114304 |
GO:0048739 | cardiac muscle fiber development | 0.015752241114304 |
GO:0031034 | myosin filament assembly | 0.015752241114304 |
GO:0021757 | caudate nucleus development | 0.015752241114304 |
GO:0021758 | putamen development | 0.015752241114304 |
GO:0030241 | muscle thick filament assembly | 0.015752241114304 |
GO:0010037 | response to carbon dioxide | 0.015752241114304 |
GO:0031033 | myosin filament assembly or disassembly | 0.015752241114304 |
GO:0007010 | cytoskeleton organization and biogenesis | 0.015807135753828 |
GO:0030198 | extracellular matrix organization and biogenesis | 0.017184705374285 |
GO:0030017 | sarcomere | 0.0182334784381034 |
GO:0005912 | adherens junction | 0.0224666838176032 |
GO:0021756 | striatum development | 0.026477198365872 |
GO:0048857 | neural nucleus development | 0.026477198365872 |
GO:0005915 | zonula adherens | 0.026477198365872 |
GO:0007519 | skeletal muscle development | 0.0313231195138409 |
GO:0048251 | elastic fiber assembly | 0.0335863878673363 |
GO:0019959 | interleukin-8 binding | 0.0335863878673363 |
GO:0004687 | myosin light chain kinase activity | 0.0335863878673363 |
GO:0014866 | skeletal myofibril assembly | 0.0335863878673363 |
GO:0021544 | subpallium development | 0.0335863878673363 |
GO:0017114 | wide-spectrum protease inhibitor activity | 0.0335863878673363 |
GO:0006125 | thioredoxin pathway | 0.0335863878673363 |
GO:0006512 | ubiquitin cycle | 0.0363311256371492 |
GO:0051239 | regulation of multicellular organismal process | 0.0387886665319578 |
GO:0043062 | extracellular structure organization and biogenesis | 0.0387886665319578 |
GO:0005862 | muscle thin filament tropomyosin | 0.0387886665319578 |
GO:0004614 | phosphoglucomutase activity | 0.0387886665319578 |
GO:0045123 | cellular extravasation | 0.0387886665319578 |
GO:0043034 | costamere | 0.0387886665319578 |
GO:0004791 | thioredoxin-disulfide reductase activity | 0.0387886665319578 |
GO:0014706 | striated muscle development | 0.0393879784106538 |
GO:0022610 | biological adhesion | 0.0406253566131771 |
GO:0007155 | cell adhesion | 0.0406253566131771 |
GO:0015081 | sodium ion transmembrane transporter activity | 0.0447304760524728 |
GO:0005587 | collagen type IV | 0.0447304760524728 |
GO:0007160 | cell-matrix adhesion | 0.0457581429225451 |
GO:0031589 | cell-substrate adhesion | 0.0486661389173214 |
GO:0004862 | cAMP-dependent protein kinase inhibitor activity | 0.0498139395661742 |
GO:0016668 | oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor | 0.0498139395661742 |
GO:0030935 | sheet-forming collagen | 0.0498139395661742 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
adult organism | 3.10e-40 | 114 |
male genital duct | 4.05e-13 | 3 |
internal male genitalia | 4.05e-13 | 3 |
intestine | 4.99e-13 | 17 |
male reproductive organ | 1.11e-12 | 11 |
gastrointestinal system | 7.58e-11 | 25 |
duct of male reproductive system | 6.09e-10 | 4 |
large intestine | 4.90e-09 | 11 |
open tracheal system trachea | 1.84e-08 | 2 |
male organism | 4.56e-08 | 22 |
male reproductive system | 4.56e-08 | 22 |
reproductive organ | 1.04e-07 | 48 |
small intestine | 1.12e-07 | 4 |
colon | 2.26e-07 | 9 |
subdivision of digestive tract | 2.45e-07 | 118 |
reproductive structure | 4.07e-07 | 59 |
reproductive system | 4.07e-07 | 59 |
internal genitalia | 6.84e-07 | 25 |
digestive system | 9.50e-07 | 145 |
digestive tract | 9.50e-07 | 145 |
primitive gut | 9.50e-07 | 145 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 1.35006e-15 |
MA0004.1 | 7.1042e-06 |
MA0006.1 | 0.0100721 |
MA0007.1 | 0.202568 |
MA0009.1 | 0.14777 |
MA0014.1 | 0 |
MA0017.1 | 0.192271 |
MA0019.1 | 0.108844 |
MA0024.1 | 0.00018603 |
MA0025.1 | 0.364427 |
MA0027.1 | 0.893371 |
MA0028.1 | 2.83347e-08 |
MA0029.1 | 0.0656872 |
MA0030.1 | 0.833082 |
MA0031.1 | 0.391337 |
MA0038.1 | 0.463159 |
MA0040.1 | 0.0699749 |
MA0041.1 | 0.681323 |
MA0042.1 | 2.5515 |
MA0043.1 | 0.148154 |
MA0046.1 | 0.239419 |
MA0048.1 | 0.75719 |
MA0050.1 | 1.29603 |
MA0051.1 | 0.700315 |
MA0052.1 | 0.0729115 |
MA0055.1 | 13.3822 |
MA0056.1 | 0 |
MA0057.1 | 3.47872e-06 |
MA0058.1 | 3.57564e-05 |
MA0059.1 | 1.07311e-05 |
MA0060.1 | 2.23411e-10 |
MA0061.1 | 0.0659822 |
MA0063.1 | 0 |
MA0066.1 | 0.0531236 |
MA0067.1 | 0.0279823 |
MA0068.1 | 0.124152 |
MA0069.1 | 0.232564 |
MA0070.1 | 0.510801 |
MA0071.1 | 0.292547 |
MA0072.1 | 0.00517867 |
MA0073.1 | 7.57479e-11 |
MA0074.1 | 0.0481618 |
MA0076.1 | 1.42398e-08 |
MA0077.1 | 0.0181641 |
MA0078.1 | 0.692448 |
MA0081.1 | 3.1593 |
MA0083.1 | 10.4219 |
MA0084.1 | 0.27425 |
MA0087.1 | 0.0193723 |
MA0088.1 | 1.23278 |
MA0089.1 | 0 |
MA0090.1 | 0.85115 |
MA0091.1 | 0.687045 |
MA0092.1 | 1.93464 |
MA0093.1 | 4.70438e-08 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.106649 |
MA0101.1 | 2.5327e-05 |
MA0103.1 | 1.51592 |
MA0105.1 | 0.0104209 |
MA0106.1 | 1.45371 |
MA0107.1 | 4.9793e-06 |
MA0108.2 | 1.12543 |
MA0109.1 | 0 |
MA0111.1 | 0.507891 |
MA0113.1 | 0.19422 |
MA0114.1 | 0.152224 |
MA0115.1 | 0.0158471 |
MA0116.1 | 0.00347791 |
MA0117.1 | 0.335355 |
MA0119.1 | 0.175931 |
MA0122.1 | 0.393856 |
MA0124.1 | 0.0546767 |
MA0125.1 | 0.0825477 |
MA0130.1 | 0 |
MA0131.1 | 0.00187511 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.00170045 |
MA0136.1 | 0.000432094 |
MA0139.1 | 0.0353443 |
MA0140.1 | 0.00585473 |
MA0141.1 | 1.3023 |
MA0142.1 | 0.123579 |
MA0143.1 | 1.87809 |
MA0144.1 | 0.877973 |
MA0145.1 | 0.0340881 |
MA0146.1 | 3.07318e-05 |
MA0147.1 | 2.72533e-09 |
MA0148.1 | 1.58213 |
MA0149.1 | 0.0546813 |
MA0062.2 | 3.98644e-10 |
MA0035.2 | 0.0226769 |
MA0039.2 | 0 |
MA0138.2 | 2.65733 |
MA0002.2 | 0.641054 |
MA0137.2 | 0.0053867 |
MA0104.2 | 2.73098e-09 |
MA0047.2 | 0.487261 |
MA0112.2 | 0.00491565 |
MA0065.2 | 3.0421 |
MA0150.1 | 0.137769 |
MA0151.1 | 0 |
MA0152.1 | 0.401743 |
MA0153.1 | 0.161696 |
MA0154.1 | 0.331575 |
MA0155.1 | 0.000118875 |
MA0156.1 | 7.76386e-05 |
MA0157.1 | 0.453976 |
MA0158.1 | 0 |
MA0159.1 | 0.0239574 |
MA0160.1 | 2.77519 |
MA0161.1 | 0 |
MA0162.1 | 0 |
MA0163.1 | 1.78234e-06 |
MA0164.1 | 0.0312872 |
MA0080.2 | 0.000127451 |
MA0018.2 | 0.0188674 |
MA0099.2 | 0.00701486 |
MA0079.2 | 0 |
MA0102.2 | 0.0943963 |
MA0258.1 | 0.0372401 |
MA0259.1 | 3.01724e-07 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data