FFCP PHASE1:Hg19::chr11:85955906..85955915,+: Difference between revisions
From FANTOM5_SSTAR
No edit summary |
No edit summary |
||
Line 7: | Line 7: | ||
|id=chr11:85955906..85955915,+ | |id=chr11:85955906..85955915,+ | ||
|ontology_enrichment_celltype= | |ontology_enrichment_celltype= | ||
|ontology_enrichment_celltype_v019=CL:0002581;5.06e-10;1!CL:0002616;5.06e-10;1 | |||
|ontology_enrichment_development_v019= | |||
|ontology_enrichment_disease=DOID:305!1.12e-11!106;DOID:0050687!1.43e-11!143;DOID:162!2.83e-11!235;DOID:14566!1.37e-10!239 | |ontology_enrichment_disease=DOID:305!1.12e-11!106;DOID:0050687!1.43e-11!143;DOID:162!2.83e-11!235;DOID:14566!1.37e-10!239 | ||
|ontology_enrichment_disease_v019= | |||
|ontology_enrichment_uberon= | |ontology_enrichment_uberon= | ||
|ontology_enrichment_uberon_v019=UBERON:0005406;2.64e-18;2!UBERON:0001872;7.24e-08;5 | |||
|phase1_expression=0,0.642301571672949,0,0,0,1.74467704820074,0,0,0,0,0,0.218441372130172,0,0,0.331397375727916,0.672325146451775,0,0,0.487932798790507,0.123121058076788,0,0.313454721478088,0.286235987131057,0.273748850145768,0,0.152826811495903,0.0821005894499457,0.236132343941038,0,0,0.154816123316076,0,0,0.369754010166788,0.232401601740905,0,0.293600439334847,0,0.200544447470142,0,0,0.32389366601898,0,0.290796477559129,0.377875943688809,0.727752183563449,0,0.822335776043652,0.619412741790207,0,0,0.236482229888585,0.344745680736619,0,0,0.188242339542605,0.272906150057846,0,1.22433556948361,0,0,1.9791078011203,0.398927315243264,0.852449501065388,0,0,0.622822248995575,0.502497330513487,0,0,0,0.368277635987565,0,0.211255286311942,0,0,0,0,0,0,0,0,0,0,0,0.426730222566507,0,0,0,0,0,0,0,0,0.560508562981536,0.263384084775077,0,0,0.205601498999509,0,0,0,0,0.111410456885174,0,0,0,0.128091319725675,0.260118695119756,0,0,0,0,0,0,0.113309342697566,0,0,0.506039384039006,0,0,0,0.301150238155546,0,0,0,0,0,0.802320587350522,0,0,0,0,0,1.00267582127178,0.434539556882471,0,0,0.189069634328136,0.443458794925128,0.351339142772504,0,0,0,0,0.174129737299267,0.26591592103773,0.715471872916026,0.571994910780128,0,0.198762407366705,0,0,0,0,0.275118041940067,0.208994966536811,0.258416759169329,0,0.33472061276467,0,0,0,0.367663080345869,0,0.0892997282840798,0.22452937262617,0.112611480483322,0,0,0.183201743930407,0,0,0,0,0,0.264818361626438,0.286836620748814,0,0,0,0,0.311211035399766,0.134710672069688,0.490385709340376,0.151357427644931,0,0,0.624320153660641,0,0.298897361103602,0.23486899728753,0,0.140450806702248,0,0,0.413303124703062,0,0,0,0,0,0.250237039743928,0,0.438977620880838,0,0.150238058906597,0.226864366320042,1.07633781413317,0.427114777637135,0.211931901159562,0.300091096084402,0.103052529238439,0,0.18611685633159,0,0.194874010322397,0.252433774244115,0.184099797284599,0.646584227275248,0,0.302256294682921,0.169560592310488,0,0,0,0,0.397589304964456,0.116193942869518,0.310983165046111,0.252320850875628,0,0,0,1.38134921352481,0,0,0.828147600278907,0.505754070234305,0.241011029883482,0.441175890929576,0.871517776369625,1.18635309555548,0.134831308160164,0.196221465125346,1.15424147083917,0,0,0,0,0,0,0.590789906681404,0,0.614942192715568,0,0.329250856225877,0,0.100528972411631,0,0,0,0,0,0.117408694235822,0,0.462985512576611,0.380508304469197,0.790204397959275,0,0,0.234004265139238,0.297262324577456,0,0,0,0.358234090811393,0,0.383382679165211,0,0.528290604079356,0,0,0.12624243342638,0.190493682876507,0.381988425558278,0,0,0.102827492703324,0,0.571652865261156,0.112131084345361,0,0.07333828582095,0,0,0,0,0,0,0,0.266422179016099,0.142977993658148,0,0.823240336780769,0.325736184293735,0,0.791951872933429,0.301439377059586,0,0.099972991182057,0,0,0,0.239624855491583,3.44585807502342,0,0,0,0.179060963239896,0.224170287987055,0,0,0,0,0,0,0.335032530668698,0,0,0,0,0,0,0,0.623912584592421,0,0.315404830067869,0.234282829985426,0,0,1.03473071292505,0.664225598535437,0,0.260650843404249,0.195801157462741,0,0,0,0.320182673410333,0.303127571446259,0,0.30239029332968,0,0.306923946576125,0,0.256278298511402,0.511707249066704,0.160853921143607,1.48418066444991,0.154209693802656,0,0.0821271560138091,0.519254429183621,0.232420756919918,0.483437798366489,0,0.0920809889358963,0,0,0,0,0,0,0,0,0,0,0.215915916102139,0,0.270946437543853,0,0,0,0,0,0,0,0,0,0.206082023295445,0.457847324091717,0.165018999841176,0,0,0,0.290012154876366,0,0,0,0.107420244868274,0.290033387828457,0,0.356128142586949,0,0.192190067365106,0.127612712494584,0.10115778085555,0.464845549297286,0.31481234683064,0,0,0.532306030317022,0,0.37064843820784,0.143124886741991,0,0,0.38126038784765,0,0,0,0,0,0,0,0,0,0,0,0.243713489631284,0,0.545999645631943,0.141405431953713,0,0,0,0.438450885253763,0,0,0,0.6196469961995,0,0.143411352204052,0.196498082026242,0,0,0.422215270595328,0.329294892959902,0,0.349934720244983,0.0962221127255121,0.670302275535787,0,0.282431402330337,0,0,0.443430153536676,0.229723400206959,0,0,0,0,0,0,0,0,0.427296284509893,0,0.490080431962063,0,0.144269212976445,0,0.159426272728822,0.199579371432817,0.191505370132367,0.423347165447766,0,0,0.456469358066384,0.313359791546046,0,0.338583555603207,0.1605880751037,0,0,0.343505344755765,0,0,0,0.976940477010201,0,0,0.540911356951966,0.66614393599564,0,0.37428108081644,0.146508179271894,0.121360521749513,0.111443384277478,0.568272293612826,0.23874448473769,0.296964680832639,0.921482106297696,0,0.422008249231538,0.333926115068718,0.16480387422676,0.844501632511974,0,0.276283915531148,0,0.102268682502155,0,0,0.539210106883961,0.358042349351218,0.511572370226872,0.295930216910801,0,0,0,0.185536196323703,0,1.30213880542617,0.0874599999961957,0,0.341380344856499,0.254253650292766,0.236387681767936,0.344743373241465,0,0.173624994933292,0,0.361789315876224,0,0.442317039724898,0,0,0.544692317594951,0.557694977114413,0.230850775511391,0.341826167541004,0.23056390438806,0.538545866458633,0.434589487688032,0.957003479195758,0.0915975934018623,0.533034776018635,0,0.156980256395025,0.166211681900156,0.451191321234361,0.392125068635479,0.167821586975843,0,0,0.421996129056054,0.489698424477443,0.424059214301822,0.432777279484182,0,0.176915129006678,0,0,0,0,0.067401132980677,0.802577647298789,0.234264445725339,0,0.391329237864179,0,0,0,0.30607276163049,0.063186579628488,0.300646838828985,0,0,0,0,0,0,0.554698692052555,0.173559738335131,0.489961987071888,2.35059857767087,0,0.171986032471617,1.35458863804719,1.09633975629278,1.39596276990456,0.0969890164884194,0.0882561266915003,0,0.411125773940253,0,0.253243183823515,0.195551382734803,0.240476460754601,0.213452994739353,0.599428828746391,0.144090417154106,0.114536596165916,0,0.14405479798815,0.372757606696298,2.12124631155116,0.271808412147228,0.313808538937,0.203996435272644,0,0,0.136905378891993,0,0.429765441419957,0,0,0,0,0.399358000997982,0.429226048136571,0.223171457441873,0.0671834724867263,0.360299883542404,1.16495949527454,0.236349546921671,0.0824158583811665,0.202210631562555,0.196854963029498,0.0846733320657845,1.59045937961861,0.544813624446302,0,0.275078873194468,0,0.2249738915515,0.77380195455795,0.242998226632099,0,0.157611414598396,0.0524545881349981,0.528001682597033,0.35857467866569,0.383830394638891,0,0,0,0,0,0,0,0.492555124496034,0,0.226624183040251,0.146552233678082,0,0.129282956361551,0.52893040697076,0,0,0,0.157204305099666,0.414239055347196,0,0,0,0.638341257770182,0,0,0,0,0.314108192500469,0,0.122026264901963,0.500763722825999,0,0.443716206147409,0.310482014706917,0.138348634936231,0.249960815924213,0.454947352624943,0,0.470531639396343,0,0,0.149254802886874,0.467426619694449,0.554805861502613,0.378806010550178,0.251567901752575,0,0,0.604923695052956,0.466311601748341,0.295710299979268,0.159296767163702,0,0.465788870628778,0,0,0.521745061811734,0.150257608997218,0.380805212168795,0,0.181848659202559,0.107410557042488,0,0,0,0,0.336749488765919,0,0,0,0.260994291965212,0.453411851024545,0.231522474323834,0.734210113519403,0,0.308801447160972,0,0.353378291891762,0.192914038270915,0,0.512483037175893,0.345430341731199,0.911579868532147,0.276516872303462,0.194860308839388,0,0.163565394255844,0,0.245772908753719,0.633936370075881,0.79994958341972,0,0,0,0.368211900503681,0.279759015438889,0,0.127894371303652,0,0,0.327628914576042,0.169732529954025,0.425149840203366,0.123935764259002,0,0,0,0,0.352675943690684,0,0.192687675289379,0,0.957803154342908,0.41023272848151,0.504143392443436,0,0.322951291263702,0,0.490738592505128,0,0,1.38630799380406,0.381382095467167,0,0,0.225630985047772,0,0,0.785720083444267,0.655087670040387,0.147856086217045,0.270150338473579,1.56215619722769,0,0.0634158101939068,1.09394961803644,0,0.496211178389294,0.175871244359621,0.511049710558381,0.535701835878287,0,0,0.455324382702595,0.177404740325278,0.115233987555779,0.171488009437418,0.135939465953663,0.328863867814245,0.118193840883968,0,0.235479278551542,0.314231179832004,0.280272163313789,0,0.431855182437243,0,0.0714765441766563,0,0.23248285073625,0.521574816907738,0,0,0.6828739083758,0,0,0.118332000730565,0.0852134047591577,0,1.60374807980835,0.62041277132864,0,0.111855431797792,0.098150233615243,0.609589624911347,0,0,0,0,0.233939463462106,0.397901550322736,0.118920090777569,0.11294608203896,0,0.754814217833368,0.385870790539723,0.437119121007915,0,0.245148321753905,0,0,0,0.4226557275834,0.679708458751268,0,0.322289439867886,0.0999411559249289,0.178553938605658,0.352894871715692,0,0,0.458729283404541,0,0,0.407948941145488,0,0,0.743990036333503,0,0.432626562123789,0.126166424835079,0.109265571963696,0.253397002022874,0.101988829741982,0,0.36757959813938,0,0.227336094654718,0,0.829169439458779,0.310298987585686,0.426467963801962,0.23806443146374,0.0645889098360061,0.0620747142958579,0.33639558774184,0.190941474834495,0,0,0,0.336760265072938,0.143444410785353,0.99798106963804,0.325613074443898,0.426909383510862,0,0.269475606319761,0,0.366724332548599,0.406896178315738,0,0,0 | |phase1_expression=0,0.642301571672949,0,0,0,1.74467704820074,0,0,0,0,0,0.218441372130172,0,0,0.331397375727916,0.672325146451775,0,0,0.487932798790507,0.123121058076788,0,0.313454721478088,0.286235987131057,0.273748850145768,0,0.152826811495903,0.0821005894499457,0.236132343941038,0,0,0.154816123316076,0,0,0.369754010166788,0.232401601740905,0,0.293600439334847,0,0.200544447470142,0,0,0.32389366601898,0,0.290796477559129,0.377875943688809,0.727752183563449,0,0.822335776043652,0.619412741790207,0,0,0.236482229888585,0.344745680736619,0,0,0.188242339542605,0.272906150057846,0,1.22433556948361,0,0,1.9791078011203,0.398927315243264,0.852449501065388,0,0,0.622822248995575,0.502497330513487,0,0,0,0.368277635987565,0,0.211255286311942,0,0,0,0,0,0,0,0,0,0,0,0.426730222566507,0,0,0,0,0,0,0,0,0.560508562981536,0.263384084775077,0,0,0.205601498999509,0,0,0,0,0.111410456885174,0,0,0,0.128091319725675,0.260118695119756,0,0,0,0,0,0,0.113309342697566,0,0,0.506039384039006,0,0,0,0.301150238155546,0,0,0,0,0,0.802320587350522,0,0,0,0,0,1.00267582127178,0.434539556882471,0,0,0.189069634328136,0.443458794925128,0.351339142772504,0,0,0,0,0.174129737299267,0.26591592103773,0.715471872916026,0.571994910780128,0,0.198762407366705,0,0,0,0,0.275118041940067,0.208994966536811,0.258416759169329,0,0.33472061276467,0,0,0,0.367663080345869,0,0.0892997282840798,0.22452937262617,0.112611480483322,0,0,0.183201743930407,0,0,0,0,0,0.264818361626438,0.286836620748814,0,0,0,0,0.311211035399766,0.134710672069688,0.490385709340376,0.151357427644931,0,0,0.624320153660641,0,0.298897361103602,0.23486899728753,0,0.140450806702248,0,0,0.413303124703062,0,0,0,0,0,0.250237039743928,0,0.438977620880838,0,0.150238058906597,0.226864366320042,1.07633781413317,0.427114777637135,0.211931901159562,0.300091096084402,0.103052529238439,0,0.18611685633159,0,0.194874010322397,0.252433774244115,0.184099797284599,0.646584227275248,0,0.302256294682921,0.169560592310488,0,0,0,0,0.397589304964456,0.116193942869518,0.310983165046111,0.252320850875628,0,0,0,1.38134921352481,0,0,0.828147600278907,0.505754070234305,0.241011029883482,0.441175890929576,0.871517776369625,1.18635309555548,0.134831308160164,0.196221465125346,1.15424147083917,0,0,0,0,0,0,0.590789906681404,0,0.614942192715568,0,0.329250856225877,0,0.100528972411631,0,0,0,0,0,0.117408694235822,0,0.462985512576611,0.380508304469197,0.790204397959275,0,0,0.234004265139238,0.297262324577456,0,0,0,0.358234090811393,0,0.383382679165211,0,0.528290604079356,0,0,0.12624243342638,0.190493682876507,0.381988425558278,0,0,0.102827492703324,0,0.571652865261156,0.112131084345361,0,0.07333828582095,0,0,0,0,0,0,0,0.266422179016099,0.142977993658148,0,0.823240336780769,0.325736184293735,0,0.791951872933429,0.301439377059586,0,0.099972991182057,0,0,0,0.239624855491583,3.44585807502342,0,0,0,0.179060963239896,0.224170287987055,0,0,0,0,0,0,0.335032530668698,0,0,0,0,0,0,0,0.623912584592421,0,0.315404830067869,0.234282829985426,0,0,1.03473071292505,0.664225598535437,0,0.260650843404249,0.195801157462741,0,0,0,0.320182673410333,0.303127571446259,0,0.30239029332968,0,0.306923946576125,0,0.256278298511402,0.511707249066704,0.160853921143607,1.48418066444991,0.154209693802656,0,0.0821271560138091,0.519254429183621,0.232420756919918,0.483437798366489,0,0.0920809889358963,0,0,0,0,0,0,0,0,0,0,0.215915916102139,0,0.270946437543853,0,0,0,0,0,0,0,0,0,0.206082023295445,0.457847324091717,0.165018999841176,0,0,0,0.290012154876366,0,0,0,0.107420244868274,0.290033387828457,0,0.356128142586949,0,0.192190067365106,0.127612712494584,0.10115778085555,0.464845549297286,0.31481234683064,0,0,0.532306030317022,0,0.37064843820784,0.143124886741991,0,0,0.38126038784765,0,0,0,0,0,0,0,0,0,0,0,0.243713489631284,0,0.545999645631943,0.141405431953713,0,0,0,0.438450885253763,0,0,0,0.6196469961995,0,0.143411352204052,0.196498082026242,0,0,0.422215270595328,0.329294892959902,0,0.349934720244983,0.0962221127255121,0.670302275535787,0,0.282431402330337,0,0,0.443430153536676,0.229723400206959,0,0,0,0,0,0,0,0,0.427296284509893,0,0.490080431962063,0,0.144269212976445,0,0.159426272728822,0.199579371432817,0.191505370132367,0.423347165447766,0,0,0.456469358066384,0.313359791546046,0,0.338583555603207,0.1605880751037,0,0,0.343505344755765,0,0,0,0.976940477010201,0,0,0.540911356951966,0.66614393599564,0,0.37428108081644,0.146508179271894,0.121360521749513,0.111443384277478,0.568272293612826,0.23874448473769,0.296964680832639,0.921482106297696,0,0.422008249231538,0.333926115068718,0.16480387422676,0.844501632511974,0,0.276283915531148,0,0.102268682502155,0,0,0.539210106883961,0.358042349351218,0.511572370226872,0.295930216910801,0,0,0,0.185536196323703,0,1.30213880542617,0.0874599999961957,0,0.341380344856499,0.254253650292766,0.236387681767936,0.344743373241465,0,0.173624994933292,0,0.361789315876224,0,0.442317039724898,0,0,0.544692317594951,0.557694977114413,0.230850775511391,0.341826167541004,0.23056390438806,0.538545866458633,0.434589487688032,0.957003479195758,0.0915975934018623,0.533034776018635,0,0.156980256395025,0.166211681900156,0.451191321234361,0.392125068635479,0.167821586975843,0,0,0.421996129056054,0.489698424477443,0.424059214301822,0.432777279484182,0,0.176915129006678,0,0,0,0,0.067401132980677,0.802577647298789,0.234264445725339,0,0.391329237864179,0,0,0,0.30607276163049,0.063186579628488,0.300646838828985,0,0,0,0,0,0,0.554698692052555,0.173559738335131,0.489961987071888,2.35059857767087,0,0.171986032471617,1.35458863804719,1.09633975629278,1.39596276990456,0.0969890164884194,0.0882561266915003,0,0.411125773940253,0,0.253243183823515,0.195551382734803,0.240476460754601,0.213452994739353,0.599428828746391,0.144090417154106,0.114536596165916,0,0.14405479798815,0.372757606696298,2.12124631155116,0.271808412147228,0.313808538937,0.203996435272644,0,0,0.136905378891993,0,0.429765441419957,0,0,0,0,0.399358000997982,0.429226048136571,0.223171457441873,0.0671834724867263,0.360299883542404,1.16495949527454,0.236349546921671,0.0824158583811665,0.202210631562555,0.196854963029498,0.0846733320657845,1.59045937961861,0.544813624446302,0,0.275078873194468,0,0.2249738915515,0.77380195455795,0.242998226632099,0,0.157611414598396,0.0524545881349981,0.528001682597033,0.35857467866569,0.383830394638891,0,0,0,0,0,0,0,0.492555124496034,0,0.226624183040251,0.146552233678082,0,0.129282956361551,0.52893040697076,0,0,0,0.157204305099666,0.414239055347196,0,0,0,0.638341257770182,0,0,0,0,0.314108192500469,0,0.122026264901963,0.500763722825999,0,0.443716206147409,0.310482014706917,0.138348634936231,0.249960815924213,0.454947352624943,0,0.470531639396343,0,0,0.149254802886874,0.467426619694449,0.554805861502613,0.378806010550178,0.251567901752575,0,0,0.604923695052956,0.466311601748341,0.295710299979268,0.159296767163702,0,0.465788870628778,0,0,0.521745061811734,0.150257608997218,0.380805212168795,0,0.181848659202559,0.107410557042488,0,0,0,0,0.336749488765919,0,0,0,0.260994291965212,0.453411851024545,0.231522474323834,0.734210113519403,0,0.308801447160972,0,0.353378291891762,0.192914038270915,0,0.512483037175893,0.345430341731199,0.911579868532147,0.276516872303462,0.194860308839388,0,0.163565394255844,0,0.245772908753719,0.633936370075881,0.79994958341972,0,0,0,0.368211900503681,0.279759015438889,0,0.127894371303652,0,0,0.327628914576042,0.169732529954025,0.425149840203366,0.123935764259002,0,0,0,0,0.352675943690684,0,0.192687675289379,0,0.957803154342908,0.41023272848151,0.504143392443436,0,0.322951291263702,0,0.490738592505128,0,0,1.38630799380406,0.381382095467167,0,0,0.225630985047772,0,0,0.785720083444267,0.655087670040387,0.147856086217045,0.270150338473579,1.56215619722769,0,0.0634158101939068,1.09394961803644,0,0.496211178389294,0.175871244359621,0.511049710558381,0.535701835878287,0,0,0.455324382702595,0.177404740325278,0.115233987555779,0.171488009437418,0.135939465953663,0.328863867814245,0.118193840883968,0,0.235479278551542,0.314231179832004,0.280272163313789,0,0.431855182437243,0,0.0714765441766563,0,0.23248285073625,0.521574816907738,0,0,0.6828739083758,0,0,0.118332000730565,0.0852134047591577,0,1.60374807980835,0.62041277132864,0,0.111855431797792,0.098150233615243,0.609589624911347,0,0,0,0,0.233939463462106,0.397901550322736,0.118920090777569,0.11294608203896,0,0.754814217833368,0.385870790539723,0.437119121007915,0,0.245148321753905,0,0,0,0.4226557275834,0.679708458751268,0,0.322289439867886,0.0999411559249289,0.178553938605658,0.352894871715692,0,0,0.458729283404541,0,0,0.407948941145488,0,0,0.743990036333503,0,0.432626562123789,0.126166424835079,0.109265571963696,0.253397002022874,0.101988829741982,0,0.36757959813938,0,0.227336094654718,0,0.829169439458779,0.310298987585686,0.426467963801962,0.23806443146374,0.0645889098360061,0.0620747142958579,0.33639558774184,0.190941474834495,0,0,0,0.336760265072938,0.143444410785353,0.99798106963804,0.325613074443898,0.426909383510862,0,0.269475606319761,0,0.366724332548599,0.406896178315738,0,0,0 | ||
|short_description=p6@EED | |short_description=p6@EED | ||
}} | }} |
Revision as of 22:47, 8 August 2012
Short description: | p6@EED |
---|---|
Species: | Human (Homo sapiens) |
DPI dataset: | NA |
TSS-like-by-RIKEN-classifier(Yes/No): | NA |
DHS support(Yes/No): | NA |
Description: | CAGE_peak_6_at_EED_5end |
Coexpression cluster: | NA |
Association with transcript: | 91bp_to_ENST00000351625, uc001pbp.2, uc001pbq.2, uc001pbr.2, uc001pbs.2, uc010rtm.1_5end |
EntrezGene: | EED |
HGNC: | 3188 |
UniProt: | NA |
Genome view: | ZENBU |
View on UCSC genome browser
CAGE Expression
- Click each plot point to find sample in table
Ontology-based sample term enrichment analysis<b>Summary:</b>This analysis has been performed by utilizing wilcoxon rank sum test.When the number of associated cells/tissues are > n , randomly sampled n cells/tissues are used for P value calculation with rank sum test. this process are repeated several times, and the P values are averaged on the log space <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source dataset<br>data
Ontology term | p-value | n |
---|
Ontology term | p-value | n |
---|
Ontology term | p-value | n |
---|
Property "Dpi dataset" (as page type) with input value "{{{DPIdataset}}}" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
Property "TSS like by RIKEN classifier" (as page type) with input value "{{{TSSclassifier}}}" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
Property "DHS support" (as page type) with input value "{{{DHSsupport}}}" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.