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{{UBERON
{{UBERON
|id=UBERON:0003820
|alt_id=
|name=prostate bud
|namespace=
|def="A region of the fetal urogenital sinus epithelium destined to become the prostate[GO]." [GO:0060513]
|xref=
|is_a=UBERON:0000077;;UBERON:0005153;;UBERON:0005291;;UBERON:0005911
|synonym="prostate ductal progenitor" EXACT [PMID:18977204];;"prostatic bud" EXACT []
|comment=AR activation releases instructive signals from UGM that acts on UGS epithelium (UGE) to stimulate cell proliferation, form prostate ductal progenitors (prostatic buds), and regulate cell adhesion dynamics to permit prostatic bud outgrowth. There are three phases of prostatic budding: (1) the specification phase, when instructive developmental cues define where buds will form in the UGS, (2) the initiation phase, when prostatic buds begin to form, and (3) the elongation phase, when proliferation, cell adhesion, and cell migration coordinate outgrowth of prostatic buds into UGM. Timing of prostatic bud formation and the quantity and pattern of buds that are formed in the UGS are strictly regulated [3, 4]. The position of prostatic buds as they emerge from the UGS in utero determines the arrangement of prostate ducts in adulthood.[PMID:18977204]
|comment=AR activation releases instructive signals from UGM that acts on UGS epithelium (UGE) to stimulate cell proliferation, form prostate ductal progenitors (prostatic buds), and regulate cell adhesion dynamics to permit prostatic bud outgrowth. There are three phases of prostatic budding: (1) the specification phase, when instructive developmental cues define where buds will form in the UGS, (2) the initiation phase, when prostatic buds begin to form, and (3) the elongation phase, when proliferation, cell adhesion, and cell migration coordinate outgrowth of prostatic buds into UGM. Timing of prostatic bud formation and the quantity and pattern of buds that are formed in the UGS are strictly regulated [3, 4]. The position of prostatic buds as they emerge from the UGS in utero determines the arrangement of prostate ducts in adulthood.[PMID:18977204]
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="A region of the fetal urogenital sinus epithelium destined to become the prostate[GO]." [GO:0060513]
|subset=
|derives_from=
|derives_from=
|develops_from=UBERON:0009847
|develops_from=UBERON:0009847
|disjoint_from=
|has_quality=
|has_quality=
|id=UBERON:0003820
|is_a=UBERON:0005153 ;;UBERON:0005291 ;;UBERON:0012275
|is_obsolete=
|located_in=
|located_in=
|name=prostate bud
|namespace=
|obo_creation_date=
|part_of=UBERON:0000922
|part_of=UBERON:0000922
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym="prostate ductal progenitor" EXACT [PMID:18977204];;"prostatic bud" EXACT []
|union_of=
|xref=
}}
}}

Revision as of 11:25, 12 September 2014

Name:prostate bud
Definition:"A region of the fetal urogenital sinus epithelium destined to become the prostate[GO]." [GO:0060513]
Synonyms: "prostate ductal progenitor" EXACT [PMID:18977204]
"prostatic bud" EXACT []
Comments:AR activation releases instructive signals from UGM that acts on UGS epithelium (UGE) to stimulate cell proliferation, form prostate ductal progenitors (prostatic buds), and regulate cell adhesion dynamics to permit prostatic bud outgrowth. There are three phases of prostatic budding: (1) the specification phase, when instructive developmental cues define where buds will form in the UGS, (2) the initiation phase, when prostatic buds begin to form, and (3) the elongation phase, when proliferation, cell adhesion, and cell migration coordinate outgrowth of prostatic buds into UGM. Timing of prostatic bud formation and the quantity and pattern of buds that are formed in the UGS are strictly regulated [3, 4]. The position of prostatic buds as they emerge from the UGS in utero determines the arrangement of prostate ducts in adulthood.[PMID:18977204]

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0005153(epithelial bud),UBERON:0005291(embryonic tissue),UBERON:0012275(meso-epithelium)
develops_from:UBERON:0009847(prostate field)
part_of:UBERON:0000922(embryo)



Children

develops from:UBERON:0002367 (prostate gland)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology



Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0003820 (prostate bud), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
3.07e-86FFCP PHASE1:Mm9::chr6:42541927..42541932,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42541927..42541932, -
3.07e-86FFCP PHASE1:Mm9::chr11:57320631..57320636,-#_adfaf032d8cca024a7d0e6a6f359ade7p5@Fam114a2
3.07e-86FFCP PHASE1:Mm9::chr6:42536830..42536841,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42536830..42536841, -
3.07e-86FFCP PHASE2:Mm9::chr6:42535901..42535907,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42535901..42535907, -
3.07e-86FFCP PHASE2:Mm9::chr12:93026806..93026816,-#_adfaf032d8cca024a7d0e6a6f359ade7p12@Ston2
3.07e-86FFCP PHASE2:Mm9::chr12:114453231..114453265,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr12:114453231..114453265, -
3.07e-86FFCP PHASE2:Mm9::chr6:42547375..42547383,-#_adfaf032d8cca024a7d0e6a6f359ade7p10@Fam115e
3.07e-86FFCP PHASE2:Mm9::chr6:54242736..54242738,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:54242736..54242738, -
3.07e-86FFCP PHASE2:Mm9::chr4:121069181..121069190,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr4:121069181..121069190, -
3.07e-86FFCP PHASE2:Mm9::chr5:33251992..33251995,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr5:33251992..33251995, +
3.07e-86FFCP PHASE2:Mm9::chr16:20186617..20186622,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr16:20186617..20186622, +
3.07e-86FFCP PHASE1:Mm9::chr9:36300946..36300953,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr9:36300946..36300953, -
3.07e-86FFCP PHASE1:Mm9::chr6:42543996..42544003,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42543996..42544003, -
3.07e-86FFCP PHASE1:Mm9::chr12:93026806..93026816,-#_adfaf032d8cca024a7d0e6a6f359ade7p12@Ston2
3.07e-86FFCP PHASE2:Mm9::chr4:102102677..102102684,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr4:102102677..102102684, +
3.07e-86FFCP PHASE1:Mm9::chr6:42535757..42535772,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42535757..42535772, -
3.07e-86FFCP PHASE2:Mm9::chr6:42551615..42551622,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42551615..42551622, -
3.07e-86FFCP PHASE1:Mm9::chr6:42539866..42539870,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42539866..42539870, -
3.07e-86FFCP PHASE2:Mm9::chr6:42536009..42536044,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42536009..42536044, +
3.07e-86FFCP PHASE1:Mm9::chr1:73048139..73048141,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr1:73048139..73048141, +
3.07e-86FFCP PHASE1:Mm9::chr2:137020090..137020093,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr2:137020090..137020093, +
3.07e-86FFCP PHASE2:Mm9::chr6:42535739..42535752,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42535739..42535752, -
3.07e-86FFCP PHASE1:Mm9::chr6:42548966..42548969,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42548966..42548969, -
3.07e-86FFCP PHASE2:Mm9::chr2:137020090..137020093,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr2:137020090..137020093, +
3.07e-86FFCP PHASE1:Mm9::chr6:42547401..42547411,-#_adfaf032d8cca024a7d0e6a6f359ade7p9@Fam115e
3.07e-86FFCP PHASE2:Mm9::chr6:42539787..42539797,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42539787..42539797, -
3.07e-86FFCP PHASE1:Mm9::chr6:57789909..57789916,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:57789909..57789916, -
3.07e-86FFCP PHASE1:Mm9::chr16:20186645..20186650,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr16:20186645..20186650, +
3.07e-86FFCP PHASE2:Mm9::chr11:57320631..57320636,-#_adfaf032d8cca024a7d0e6a6f359ade7p5@Fam114a2
3.07e-86FFCP PHASE2:Mm9::chr9:7867982..7867988,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr9:7867982..7867988, -
3.07e-86FFCP PHASE1:Mm9::chr2:36098306..36098309,+#_adfaf032d8cca024a7d0e6a6f359ade7p5@Ptgs1
3.07e-86FFCP PHASE2:Mm9::chr6:22342065..22342073,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:22342065..22342073, -
3.07e-86FFCP PHASE2:Mm9::chr6:42547389..42547396,-#_adfaf032d8cca024a7d0e6a6f359ade7p14@Fam115e
3.07e-86FFCP PHASE1:Mm9::chr1:72981474..72981498,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr1:72981474..72981498, +
3.07e-86FFCP PHASE2:Mm9::chr6:42541927..42541932,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42541927..42541932, -
3.07e-86FFCP PHASE2:Mm9::chr4:122366201..122366206,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr4:122366201..122366206, -
3.07e-86FFCP PHASE2:Mm9::chr16:20186645..20186650,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr16:20186645..20186650, +
3.07e-86FFCP PHASE1:Mm9::chr8:126864466..126864469,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr8:126864466..126864469, +
3.07e-86FFCP PHASE2:Mm9::chr6:42536830..42536841,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42536830..42536841, -
3.07e-86FFCP PHASE1:Mm9::chr6:54242736..54242738,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:54242736..54242738, -
3.07e-86FFCP PHASE2:Mm9::chr8:126864466..126864469,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr8:126864466..126864469, +
3.07e-86FFCP PHASE2:Mm9::chr6:42551847..42551862,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42551847..42551862, -
3.07e-86FFCP PHASE1:Mm9::chr7:55002686..55002717,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr7:55002686..55002717, +
3.07e-86FFCP PHASE2:Mm9::chr6:42535757..42535772,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42535757..42535772, -
3.07e-86FFCP PHASE1:Mm9::chr6:42551615..42551622,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42551615..42551622, -
3.07e-86FFCP PHASE2:Mm9::chr6:42543996..42544003,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42543996..42544003, -
3.07e-86FFCP PHASE1:Mm9::chr16:96752893..96752921,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr16:96752893..96752921, +
3.07e-86FFCP PHASE1:Mm9::chr10:75355747..75355754,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr10:75355747..75355754, -
3.07e-86FFCP PHASE2:Mm9::chr9:122970904..122970907,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr9:122970904..122970907, -
3.07e-86FFCP PHASE2:Mm9::chr6:42539866..42539870,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42539866..42539870, -
3.07e-86FFCP PHASE1:Mm9::chr6:42535984..42535996,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42535984..42535996, -
3.07e-86FFCP PHASE1:Mm9::chr16:20188864..20188875,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr16:20188864..20188875, +
3.07e-86FFCP PHASE1:Mm9::chr5:33251992..33251995,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr5:33251992..33251995, +
3.07e-86FFCP PHASE2:Mm9::chr9:36341608..36341609,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr9:36341608..36341609, -
3.07e-86FFCP PHASE1:Mm9::chr7:55028223..55028250,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr7:55028223..55028250, +
3.07e-86FFCP PHASE1:Mm9::chr6:42535216..42535225,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42535216..42535225, +
3.07e-86FFCP PHASE2:Mm9::chr6:42547830..42547837,-#_adfaf032d8cca024a7d0e6a6f359ade7p8@Fam115e
3.07e-86FFCP PHASE2:Mm9::chr16:20188864..20188875,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr16:20188864..20188875, +
3.07e-86FFCP PHASE1:Mm9::chr19:11353179..11353189,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr19:11353179..11353189, -
3.07e-86FFCP PHASE1:Mm9::chr6:122422716..122422728,-#_adfaf032d8cca024a7d0e6a6f359ade7p15@Rimklb
3.07e-86FFCP PHASE2:Mm9::chr2:80164541..80164545,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr2:80164541..80164545, +
3.07e-86FFCP PHASE1:Mm9::chr9:122970904..122970907,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr9:122970904..122970907, -
3.07e-86FFCP PHASE2:Mm9::chr7:55002686..55002717,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr7:55002686..55002717, +
3.07e-86FFCP PHASE1:Mm9::chr6:42547300..42547314,-#_adfaf032d8cca024a7d0e6a6f359ade7p7@Fam115e
3.07e-86FFCP PHASE2:Mm9::chrX:75093379..75093383,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chrX:75093379..75093383, +
3.07e-86FFCP PHASE1:Mm9::chrX:75093379..75093383,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chrX:75093379..75093383, +
3.07e-86FFCP PHASE1:Mm9::chr7:55008002..55008008,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr7:55008002..55008008, -
3.07e-86FFCP PHASE1:Mm9::chrX:137642090..137642093,-#_adfaf032d8cca024a7d0e6a6f359ade7p8@Col4a6
3.07e-86FFCP PHASE1:Mm9::chr6:22342065..22342073,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:22342065..22342073, -
3.07e-86FFCP PHASE2:Mm9::chr1:37769602..37769611,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr1:37769602..37769611, -
3.07e-86FFCP PHASE2:Mm9::chr9:7699504..7699515,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr9:7699504..7699515, +
3.07e-86FFCP PHASE1:Mm9::chr6:42551847..42551862,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42551847..42551862, -
3.07e-86FFCP PHASE1:Mm9::chr9:7699504..7699515,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr9:7699504..7699515, +
3.07e-86FFCP PHASE1:Mm9::chr4:102102677..102102684,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr4:102102677..102102684, +
3.07e-86FFCP PHASE2:Mm9::chr10:75355747..75355754,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr10:75355747..75355754, -
3.07e-86FFCP PHASE1:Mm9::chr1:37769602..37769611,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr1:37769602..37769611, -
3.07e-86FFCP PHASE2:Mm9::chr6:134172953..134172958,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:134172953..134172958, +
3.07e-86FFCP PHASE1:Mm9::chr6:42536469..42536478,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42536469..42536478, -
3.07e-86FFCP PHASE2:Mm9::chr7:55028223..55028250,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr7:55028223..55028250, +
3.07e-86FFCP PHASE1:Mm9::chr9:36341608..36341609,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr9:36341608..36341609, -
3.07e-86FFCP PHASE2:Mm9::chr19:11353179..11353189,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr19:11353179..11353189, -
3.07e-86FFCP PHASE1:Mm9::chr6:42536000..42536005,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42536000..42536005, -
3.07e-86FFCP PHASE1:Mm9::chr16:20188882..20188884,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr16:20188882..20188884, +
3.07e-86FFCP PHASE1:Mm9::chr6:42543450..42543455,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42543450..42543455, -
3.07e-86FFCP PHASE2:Mm9::chr6:42548119..42548136,-#_adfaf032d8cca024a7d0e6a6f359ade7p12@Fam115e
3.07e-86FFCP PHASE1:Mm9::chr6:42537176..42537182,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42537176..42537182, -
3.07e-86FFCP PHASE2:Mm9::chr9:36300946..36300953,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr9:36300946..36300953, -
3.07e-86FFCP PHASE2:Mm9::chr6:42535984..42535996,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42535984..42535996, -
3.07e-86FFCP PHASE1:Mm9::chr6:134172953..134172958,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:134172953..134172958, +
3.07e-86FFCP PHASE1:Mm9::chr4:121069181..121069190,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr4:121069181..121069190, -
3.07e-86FFCP PHASE2:Mm9::chr6:42547401..42547411,-#_adfaf032d8cca024a7d0e6a6f359ade7p9@Fam115e
3.07e-86FFCP PHASE2:Mm9::chr16:20188882..20188884,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr16:20188882..20188884, +
3.07e-86FFCP PHASE2:Mm9::chr6:42535216..42535225,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr6:42535216..42535225, +
3.07e-86FFCP PHASE1:Mm9::chr6:42547830..42547837,-#_adfaf032d8cca024a7d0e6a6f359ade7p8@Fam115e
3.07e-86FFCP PHASE2:Mm9::chr7:55008002..55008008,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chr7:55008002..55008008, -
3.07e-86FFCP PHASE2:Mm9::chr9:122970758..122970759,+#_adfaf032d8cca024a7d0e6a6f359ade7p@chr9:122970758..122970759, +
3.07e-86FFCP PHASE1:Mm9::chr6:42547375..42547383,-#_adfaf032d8cca024a7d0e6a6f359ade7p10@Fam115e
3.07e-86FFCP PHASE2:Mm9::chrX:75093387..75093390,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chrX:75093387..75093390, -
3.07e-86FFCP PHASE2:Mm9::chrX:137642090..137642093,-#_adfaf032d8cca024a7d0e6a6f359ade7p8@Col4a6
3.07e-86FFCP PHASE1:Mm9::chrX:75093387..75093390,-#_adfaf032d8cca024a7d0e6a6f359ade7p@chrX:75093387..75093390, -

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