FFCP PHASE1:Hg19::chr19:18652724..18652739,-: Difference between revisions
From FANTOM5_SSTAR
No edit summary |
|||
Line 8: | Line 8: | ||
|id=chr19:18652724..18652739,- | |id=chr19:18652724..18652739,- | ||
|ontology_enrichment_celltype= | |ontology_enrichment_celltype= | ||
|ontology_enrichment_celltype_v019=CL:0002617;6.46e-09;2!CL:0000136;2.00e-07;13 | |||
|ontology_enrichment_development_v019= | |||
|ontology_enrichment_disease= | |ontology_enrichment_disease= | ||
|ontology_enrichment_disease_v019= | |||
|ontology_enrichment_uberon= | |ontology_enrichment_uberon= | ||
|ontology_enrichment_uberon_v019=UBERON:0000178;4.93e-13;15!UBERON:0000179;4.93e-13;15!UBERON:0000463;4.93e-13;15 | |||
|phase1_expression=1.09007027562334,1.2846031433459,0.422863212287913,1.0007329835313,1.78784437770915,0,0,1.89515962028049,0,0,1.39560233594486,0,0,0.247532705920093,0,1.34465029290355,0.602694528023977,0,0,0.123121058076788,0.408001382488506,0.313454721478088,0.286235987131057,0.410623275218653,0,0.152826811495903,0.0821005894499457,0.0787107813136792,0,0,0,0,0.90361775633475,0.369754010166788,0,0,0.293600439334847,0,0.200544447470142,0.217010870715852,1.11957737119962,0,0,0.436194716338694,0,0.242584061187816,0,0,0,0,0,0.236482229888585,0.344745680736619,0,0,0,0.272906150057846,0,0,0,0,0.329851300186716,0,0,0,0,0,0,0.521482918420201,0,0,0,0.316462387440884,0,0.212604299965044,0,0.22465726229299,0.150176892841506,0.32145117339416,0,0.19891667719909,0.365328307529268,0,0,0.889509253863555,0,0,0,0,0.954053754535364,0.569212969109448,0,0.382273228125229,0,0,0,0,0.393010762749165,0.205601498999509,0.167186495390678,0,0,0,0.334231370655521,0,0,0.270803863765016,0.25618263945135,0,0.164437904603676,0.552700035571697,0.289803085735052,0.296573126324121,0.535081656179426,0,0.113309342697566,0.383220493601921,0.34362744548263,0.253019692019503,0.318565414324097,0,0,0.451725357233318,0,0,0.236777252044017,0,0.201606743224732,0,0.579297615531196,2.43806866313962,0.670700859703636,0,0,0,0.434539556882471,0,0,0.0945348171640679,0,0.263504357079378,0.196468613246569,0.364295288292542,0,0,0.348259474598534,0.132957960518865,0,0.571994910780128,0.371457501329565,0.39752481473341,0,0,0,0.419499436209906,0,0,0.258416759169329,0,0.66944122552934,0,0.760272105718513,0.488124115096339,0,0,0.0892997282840798,0,0,0,0,0.183201743930407,0,0,0.436094052142534,0.496971951695318,0.12663051166458,0.132409180813219,0,0,0.560677600142307,1.06748995729705,0.49333509683432,0,0.134710672069688,0.326923806226917,0,0.576175924479999,0.234321431833797,0.312160076830321,0.570471821544449,0.149448680551801,0.23486899728753,0,0.140450806702248,0.204154171254893,0,0.206651562351531,0,0.494533858557114,0,0,0,0.375355559615893,0,0,0,0.300476117813194,0.113432183160021,0,0,0,0,0.309157587715317,0,0.558350568994769,0,0.0974370051611986,0,0.184099797284599,0.323292113637624,0,0.302256294682921,0.339121184620975,0,0,0,0.365921118388786,0.397589304964456,0.464775771478074,0.10366105501537,0.504641701751257,0.36497735907583,0,0,1.38134921352481,0,0.721879481669586,0,0.168584690078102,0,0,0,0,0,0,0.38474715694639,0,0,0,0,0,0.982827216677626,0,0,0,0.171567810298526,0.329250856225877,1.1240175325762,0.100528972411631,0,0.651616610620649,0,1.44331342025273,0.115930404975077,0,0,0,0.190254152234598,0,1.71697232418975,0.246217006087397,0,0.297262324577456,0,0,0.141775097242386,0,0,0.383382679165211,0,0,0.207328115540772,0.576479813667846,0.6312121671319,0,1.90994212779139,7.03304683260282,0,0.308482478109971,0,0.285826432630578,0,0,0,0.258543431515556,0,0,0,0,0.257207374262142,0,0,0.142977993658148,0,0,0,0,0,1.20575750823834,0,0.399891964728228,0,0,0,0,1.14861935834114,0,0.144781306667579,0.410952645100767,0,0.224170287987055,0,0.862510299438069,0.128343036279748,0,0,0,0.167516265334349,0,0,2.99161459204025,0,0.12269149171914,0,0.813795071099207,0.207970861530807,0.178428988797162,0.630809660135739,0,3.00946099727719,18.1926003244788,0,0,0.184369168541703,0.0868836144680828,0.195801157462741,0.686286847621712,0.206768026122887,0.431428401637234,0,0.303127571446259,3.32870879020994,0.604780586659361,0.496215615637554,0.153461973288062,0.561320188866147,0.896974044789907,0,0.482561763430822,2.96836132889982,0.154209693802656,0.887808626565635,0.246381468041427,0,0.116210378459959,0.241718899183244,0.802025881213139,0.276242966807689,0.34444334449382,0,1.96686622439136,0,0.0770153371044148,0,0,0.105551628892876,0,0.340187410553031,0.215915916102139,0,0,0.501689773854853,0,0,0,1.09629938322967,0.522870902049801,0,0,0,0.103041011647722,0.27470839445503,0,0,1.30012049207304,0,0.290012154876366,0.308097234229289,0,0.137836572484531,0.214840489736547,0.435050081742686,0.0852266274161009,0,0,0,0,0,0.929691098594572,0.31481234683064,0,0,2.12922412126809,0,0,0.286249773483982,0,0,0.190630193923825,0,0,0.318203247925937,1.56989728039846,0.179872457583315,0.823611089208164,0.117812402345686,0.404364963146632,0,0.421258456238981,0,0,0,0.136499911407986,1.1312434556297,1.13008116620243,0.551365343546124,0,0.876901770507525,0,0,0,0.30982349809975,0,0,0,0,1.06428319221179,0.633322905892992,0.987884678879706,0,0.349934720244983,0.577332676353072,1.34060455107157,1.08890984861323,0.188287601553558,0,0,0.886860307073351,0,2.02979043692868,1.52927441428475,3.98753031021914,0.238231775457789,1.64544909234478,0,2.16012574895246,4.75875105776562,0.320472213382419,0,0.245040215981032,0.371606350251437,0,0,0,0.199579371432817,0,0,0,0.561594356226918,0,0.156679895773023,0,0,0.1605880751037,0,0,0.687010689511529,0,0,0,0,0.278406173895242,1.23087398947712,0,0,0,0.37428108081644,0,0.121360521749513,0.222886768554957,0,0.23874448473769,0.593929361665277,0.921482106297696,0,0.140669416410513,0,0.16480387422676,0,0.19924798825107,0,0,0.102268682502155,0.123084805461069,0.311039587661807,0.179736702294654,0,0.511572370226872,0.493217028184668,2.3948309234694,0,0.969332746095218,0.278304294485554,0,0,0,0,0,0,0,0,0,0,0,0.482385754501632,0,0.110579259931225,0,0.658156191461918,0.10893846351899,0,0.230850775511391,0.113942055847001,0.23056390438806,0.628303510868405,0.108647371922008,0.31900115973192,0.641183153813036,0,0,0,0,0.225595660617181,0.19606253431774,0,0.189753732724185,0.158936578980379,0.210998064528027,0,0.141353071433941,0,0,0.176915129006678,0,0,0.123563938946503,0,0.134802265961354,0,0.234264445725339,0.364909578431332,0,0.242780379534093,0,0,0.30607276163049,0.189559738885464,0.60129367765797,0.207376382794494,0,0.330991955875499,0,0,0,0,0.173559738335131,0,0,0.52418000472609,0,0,0,0.164230914106418,0.290967049465258,0.0882561266915003,0,0,0,0.126621591911757,0,0.0801588202515337,0.213452994739353,0.39961921916426,0,0,0,0,0.124252535565433,0.235694034616795,0.135904206073614,0,0.203996435272644,0,0.600420288709789,0.136905378891993,0,0,0,0.279282401272254,0.229160424011684,0.717873024576814,0.399358000997982,0.429226048136571,0.223171457441873,0,0,0,0,0.164831716762333,0.0674035438541849,0,0.0846733320657845,0,0.136203406111576,0.321506296930038,0.275078873194468,0,0,0,0.242998226632099,0,0.157611414598396,0.104909176269996,0,0.537862017998534,0,1.42939065274673,0,0,2.17199840701485,0,0,0,0.246277562248017,0.340776043570843,0,0,1.32506888912221,0.129282956361551,0.13223260174269,0.342173675768659,0,0.106787412567695,0.157204305099666,0.414239055347196,0.496166021811951,0.197611631897944,0.121792598380896,0,0.544017803369474,0.7520696820681,0.306345576763462,0,0,0.886068179966986,0.244052529803926,0.250381861413,0.573409195690071,0.332787154610557,0.18628920882415,0,0.37494122388632,0.303298235083296,0.856396000634902,0.235265819698172,0,0.434763085832475,0.298509605773748,0.701139929541673,0.554805861502613,0.189403005275089,0.50313580350515,1.77962244319307,0.457680136793847,0.604923695052956,0.466311601748341,0.147855149989634,0.159296767163702,0.899606224327209,0,0.414706207840855,0.265841714557995,0.521745061811734,0,0.380805212168795,0,0.363697318405119,0.429642228169954,0.464033759878494,0.796191777397232,0.800055529326307,0,0.336749488765919,0,0,0,0.260994291965212,0,0,0,0.537266523244462,0,0,0,0,0,0,0,0,0.829550616910385,0.194860308839388,0.265729680626726,0.654261577023377,0.655219697692825,0,0,0.19998739585493,0.106691729694141,0.344429959321631,0,0.184105950251841,0.139879507719444,0,0.127894371303652,0,0.157265941855896,0.109209638192014,0,0.425149840203366,0.371807292777007,0,0,0,0,0,1.531227386766,0.256916900385838,0,0.159633859057151,2.2562800066483,0,0.0691572524642179,0.968853873791107,1.42769420259154,0.392590874004102,0.11796972334774,0,0,0,0,0.198916222116275,0.225630985047772,0,0,0,0.49131575253029,0,0.202612753855184,0.781078098613847,0.413373593002368,0,0,0,0.992422356778588,0,0,0,0,0,0,0.0887023701626388,0,0,0.271878931907327,0.263091094251396,0.236387681767936,0.111231401892069,0.078493092850514,0.157115589916002,0,0,0,0,0.214429632529969,0,0.116241425368125,0,0,0.414432328326074,0.17071847709395,0.691259661814092,0,0.118332000730565,0.0852134047591577,0.846774100381858,0.4582137370881,1.24082554265728,1.91107787795487,0.335566295393377,0,0.121917924982269,0.647428837187895,0.205325613712494,0,0.971421986118279,0,0,0.237840181555137,0,0.109940516745429,0,0.231522474323834,0,0,0,0,0.392616934229891,0,0.4226557275834,0,0,0.386747327841463,0,0.357107877211315,0,0,0.730336388246517,0,0.286679166302903,0.315543124386369,0.407948941145488,0.872701380680755,0,0.371995018166751,0,0.432626562123789,0,0,0,0.305966489225945,0.534434810531121,0.0918948995348449,0.250707539292375,0.606229585745915,0.267964130156178,0,0.620597975171371,0,0,0.129177819672012,0.124149428591716,0.112131862580613,0.12729431655633,0,0.435433495793923,0,0,0.0717222053926763,0,0.0814032686109745,0.213454691755431,0,0,0,0.122241444182866,0,0,0,0 | |phase1_expression=1.09007027562334,1.2846031433459,0.422863212287913,1.0007329835313,1.78784437770915,0,0,1.89515962028049,0,0,1.39560233594486,0,0,0.247532705920093,0,1.34465029290355,0.602694528023977,0,0,0.123121058076788,0.408001382488506,0.313454721478088,0.286235987131057,0.410623275218653,0,0.152826811495903,0.0821005894499457,0.0787107813136792,0,0,0,0,0.90361775633475,0.369754010166788,0,0,0.293600439334847,0,0.200544447470142,0.217010870715852,1.11957737119962,0,0,0.436194716338694,0,0.242584061187816,0,0,0,0,0,0.236482229888585,0.344745680736619,0,0,0,0.272906150057846,0,0,0,0,0.329851300186716,0,0,0,0,0,0,0.521482918420201,0,0,0,0.316462387440884,0,0.212604299965044,0,0.22465726229299,0.150176892841506,0.32145117339416,0,0.19891667719909,0.365328307529268,0,0,0.889509253863555,0,0,0,0,0.954053754535364,0.569212969109448,0,0.382273228125229,0,0,0,0,0.393010762749165,0.205601498999509,0.167186495390678,0,0,0,0.334231370655521,0,0,0.270803863765016,0.25618263945135,0,0.164437904603676,0.552700035571697,0.289803085735052,0.296573126324121,0.535081656179426,0,0.113309342697566,0.383220493601921,0.34362744548263,0.253019692019503,0.318565414324097,0,0,0.451725357233318,0,0,0.236777252044017,0,0.201606743224732,0,0.579297615531196,2.43806866313962,0.670700859703636,0,0,0,0.434539556882471,0,0,0.0945348171640679,0,0.263504357079378,0.196468613246569,0.364295288292542,0,0,0.348259474598534,0.132957960518865,0,0.571994910780128,0.371457501329565,0.39752481473341,0,0,0,0.419499436209906,0,0,0.258416759169329,0,0.66944122552934,0,0.760272105718513,0.488124115096339,0,0,0.0892997282840798,0,0,0,0,0.183201743930407,0,0,0.436094052142534,0.496971951695318,0.12663051166458,0.132409180813219,0,0,0.560677600142307,1.06748995729705,0.49333509683432,0,0.134710672069688,0.326923806226917,0,0.576175924479999,0.234321431833797,0.312160076830321,0.570471821544449,0.149448680551801,0.23486899728753,0,0.140450806702248,0.204154171254893,0,0.206651562351531,0,0.494533858557114,0,0,0,0.375355559615893,0,0,0,0.300476117813194,0.113432183160021,0,0,0,0,0.309157587715317,0,0.558350568994769,0,0.0974370051611986,0,0.184099797284599,0.323292113637624,0,0.302256294682921,0.339121184620975,0,0,0,0.365921118388786,0.397589304964456,0.464775771478074,0.10366105501537,0.504641701751257,0.36497735907583,0,0,1.38134921352481,0,0.721879481669586,0,0.168584690078102,0,0,0,0,0,0,0.38474715694639,0,0,0,0,0,0.982827216677626,0,0,0,0.171567810298526,0.329250856225877,1.1240175325762,0.100528972411631,0,0.651616610620649,0,1.44331342025273,0.115930404975077,0,0,0,0.190254152234598,0,1.71697232418975,0.246217006087397,0,0.297262324577456,0,0,0.141775097242386,0,0,0.383382679165211,0,0,0.207328115540772,0.576479813667846,0.6312121671319,0,1.90994212779139,7.03304683260282,0,0.308482478109971,0,0.285826432630578,0,0,0,0.258543431515556,0,0,0,0,0.257207374262142,0,0,0.142977993658148,0,0,0,0,0,1.20575750823834,0,0.399891964728228,0,0,0,0,1.14861935834114,0,0.144781306667579,0.410952645100767,0,0.224170287987055,0,0.862510299438069,0.128343036279748,0,0,0,0.167516265334349,0,0,2.99161459204025,0,0.12269149171914,0,0.813795071099207,0.207970861530807,0.178428988797162,0.630809660135739,0,3.00946099727719,18.1926003244788,0,0,0.184369168541703,0.0868836144680828,0.195801157462741,0.686286847621712,0.206768026122887,0.431428401637234,0,0.303127571446259,3.32870879020994,0.604780586659361,0.496215615637554,0.153461973288062,0.561320188866147,0.896974044789907,0,0.482561763430822,2.96836132889982,0.154209693802656,0.887808626565635,0.246381468041427,0,0.116210378459959,0.241718899183244,0.802025881213139,0.276242966807689,0.34444334449382,0,1.96686622439136,0,0.0770153371044148,0,0,0.105551628892876,0,0.340187410553031,0.215915916102139,0,0,0.501689773854853,0,0,0,1.09629938322967,0.522870902049801,0,0,0,0.103041011647722,0.27470839445503,0,0,1.30012049207304,0,0.290012154876366,0.308097234229289,0,0.137836572484531,0.214840489736547,0.435050081742686,0.0852266274161009,0,0,0,0,0,0.929691098594572,0.31481234683064,0,0,2.12922412126809,0,0,0.286249773483982,0,0,0.190630193923825,0,0,0.318203247925937,1.56989728039846,0.179872457583315,0.823611089208164,0.117812402345686,0.404364963146632,0,0.421258456238981,0,0,0,0.136499911407986,1.1312434556297,1.13008116620243,0.551365343546124,0,0.876901770507525,0,0,0,0.30982349809975,0,0,0,0,1.06428319221179,0.633322905892992,0.987884678879706,0,0.349934720244983,0.577332676353072,1.34060455107157,1.08890984861323,0.188287601553558,0,0,0.886860307073351,0,2.02979043692868,1.52927441428475,3.98753031021914,0.238231775457789,1.64544909234478,0,2.16012574895246,4.75875105776562,0.320472213382419,0,0.245040215981032,0.371606350251437,0,0,0,0.199579371432817,0,0,0,0.561594356226918,0,0.156679895773023,0,0,0.1605880751037,0,0,0.687010689511529,0,0,0,0,0.278406173895242,1.23087398947712,0,0,0,0.37428108081644,0,0.121360521749513,0.222886768554957,0,0.23874448473769,0.593929361665277,0.921482106297696,0,0.140669416410513,0,0.16480387422676,0,0.19924798825107,0,0,0.102268682502155,0.123084805461069,0.311039587661807,0.179736702294654,0,0.511572370226872,0.493217028184668,2.3948309234694,0,0.969332746095218,0.278304294485554,0,0,0,0,0,0,0,0,0,0,0,0.482385754501632,0,0.110579259931225,0,0.658156191461918,0.10893846351899,0,0.230850775511391,0.113942055847001,0.23056390438806,0.628303510868405,0.108647371922008,0.31900115973192,0.641183153813036,0,0,0,0,0.225595660617181,0.19606253431774,0,0.189753732724185,0.158936578980379,0.210998064528027,0,0.141353071433941,0,0,0.176915129006678,0,0,0.123563938946503,0,0.134802265961354,0,0.234264445725339,0.364909578431332,0,0.242780379534093,0,0,0.30607276163049,0.189559738885464,0.60129367765797,0.207376382794494,0,0.330991955875499,0,0,0,0,0.173559738335131,0,0,0.52418000472609,0,0,0,0.164230914106418,0.290967049465258,0.0882561266915003,0,0,0,0.126621591911757,0,0.0801588202515337,0.213452994739353,0.39961921916426,0,0,0,0,0.124252535565433,0.235694034616795,0.135904206073614,0,0.203996435272644,0,0.600420288709789,0.136905378891993,0,0,0,0.279282401272254,0.229160424011684,0.717873024576814,0.399358000997982,0.429226048136571,0.223171457441873,0,0,0,0,0.164831716762333,0.0674035438541849,0,0.0846733320657845,0,0.136203406111576,0.321506296930038,0.275078873194468,0,0,0,0.242998226632099,0,0.157611414598396,0.104909176269996,0,0.537862017998534,0,1.42939065274673,0,0,2.17199840701485,0,0,0,0.246277562248017,0.340776043570843,0,0,1.32506888912221,0.129282956361551,0.13223260174269,0.342173675768659,0,0.106787412567695,0.157204305099666,0.414239055347196,0.496166021811951,0.197611631897944,0.121792598380896,0,0.544017803369474,0.7520696820681,0.306345576763462,0,0,0.886068179966986,0.244052529803926,0.250381861413,0.573409195690071,0.332787154610557,0.18628920882415,0,0.37494122388632,0.303298235083296,0.856396000634902,0.235265819698172,0,0.434763085832475,0.298509605773748,0.701139929541673,0.554805861502613,0.189403005275089,0.50313580350515,1.77962244319307,0.457680136793847,0.604923695052956,0.466311601748341,0.147855149989634,0.159296767163702,0.899606224327209,0,0.414706207840855,0.265841714557995,0.521745061811734,0,0.380805212168795,0,0.363697318405119,0.429642228169954,0.464033759878494,0.796191777397232,0.800055529326307,0,0.336749488765919,0,0,0,0.260994291965212,0,0,0,0.537266523244462,0,0,0,0,0,0,0,0,0.829550616910385,0.194860308839388,0.265729680626726,0.654261577023377,0.655219697692825,0,0,0.19998739585493,0.106691729694141,0.344429959321631,0,0.184105950251841,0.139879507719444,0,0.127894371303652,0,0.157265941855896,0.109209638192014,0,0.425149840203366,0.371807292777007,0,0,0,0,0,1.531227386766,0.256916900385838,0,0.159633859057151,2.2562800066483,0,0.0691572524642179,0.968853873791107,1.42769420259154,0.392590874004102,0.11796972334774,0,0,0,0,0.198916222116275,0.225630985047772,0,0,0,0.49131575253029,0,0.202612753855184,0.781078098613847,0.413373593002368,0,0,0,0.992422356778588,0,0,0,0,0,0,0.0887023701626388,0,0,0.271878931907327,0.263091094251396,0.236387681767936,0.111231401892069,0.078493092850514,0.157115589916002,0,0,0,0,0.214429632529969,0,0.116241425368125,0,0,0.414432328326074,0.17071847709395,0.691259661814092,0,0.118332000730565,0.0852134047591577,0.846774100381858,0.4582137370881,1.24082554265728,1.91107787795487,0.335566295393377,0,0.121917924982269,0.647428837187895,0.205325613712494,0,0.971421986118279,0,0,0.237840181555137,0,0.109940516745429,0,0.231522474323834,0,0,0,0,0.392616934229891,0,0.4226557275834,0,0,0.386747327841463,0,0.357107877211315,0,0,0.730336388246517,0,0.286679166302903,0.315543124386369,0.407948941145488,0.872701380680755,0,0.371995018166751,0,0.432626562123789,0,0,0,0.305966489225945,0.534434810531121,0.0918948995348449,0.250707539292375,0.606229585745915,0.267964130156178,0,0.620597975171371,0,0,0.129177819672012,0.124149428591716,0.112131862580613,0.12729431655633,0,0.435433495793923,0,0,0.0717222053926763,0,0.0814032686109745,0.213454691755431,0,0,0,0.122241444182866,0,0,0,0 | ||
|short_description=p10@FKBP8 | |short_description=p10@FKBP8 | ||
}} | }} |
Revision as of 07:18, 8 August 2012
Short description: | p10@FKBP8 |
---|---|
Species: | Human (Homo sapiens) |
DPI dataset: | NA |
TSS-like-by-RIKEN-classifier(Yes/No): | NA |
DHS support(Yes/No): | NA |
Description: | CAGE_peak_10_at_FKBP8_5end |
Coexpression cluster: | C315_Osteoblast_Preadipocyte_mesenchymal_Smooth_Cardiac_leiomyoma_Adipocyte |
Association with transcript: | 65bp_to_uc002njn.2_5end |
EntrezGene: | FKBP8 |
HGNC: | 3724 |
UniProt: | NA |
Genome view: | ZENBU |
View on UCSC genome browser
CAGE Expression
- Click each plot point to find sample in table
Ontology-based sample term enrichment analysis<b>Summary:</b>This analysis has been performed by utilizing wilcoxon rank sum test.When the number of associated cells/tissues are > n , randomly sampled n cells/tissues are used for P value calculation with rank sum test. this process are repeated several times, and the P values are averaged on the log space <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source dataset<br>data
Ontology term | p-value | n |
---|
Ontology term | p-value | n |
---|
Ontology term | p-value | n |
---|
Property "Dpi dataset" (as page type) with input value "{{{DPIdataset}}}" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
Property "TSS like by RIKEN classifier" (as page type) with input value "{{{TSSclassifier}}}" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
Property "DHS support" (as page type) with input value "{{{DHSsupport}}}" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.