MCL coexpression mm9:1045

Phase1 CAGE Peaks

	Short description
Mm9::chr10:80392977..80392985,+	p4@Gadd45b
Mm9::chr15:61819234..61819308,+	p@chr15:61819234..61819308 +
Mm9::chr15:61819573..61819671,+	p@chr15:61819573..61819671 +
Mm9::chr15:61821037..61821049,+	p@chr15:61821037..61821049 +
Mm9::chr3:58218663..58218693,+	p@chr3:58218663..58218693 +
Mm9::chr3:58218700..58218716,+	p@chr3:58218700..58218716 +
Mm9::chr6:83392692..83392718,-	p@chr6:83392692..83392718 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043085	positive regulation of catalytic activity	0.00848527128717106
GO:0008633	activation of pro-apoptotic gene products	0.00848527128717106
GO:0050790	regulation of catalytic activity	0.00848527128717106
GO:0008634	negative regulation of survival gene product activity	0.00848527128717106
GO:0065009	regulation of a molecular function	0.00848527128717106
GO:0001783	B cell apoptosis	0.00848527128717106
GO:0051726	regulation of cell cycle	0.00848527128717106
GO:0042474	middle ear morphogenesis	0.00941046571901774
GO:0006309	DNA fragmentation during apoptosis	0.00941046571901774
GO:0050910	detection of mechanical stimulus during sensory perception of sound	0.00941046571901774
GO:0006921	cell structure disassembly during apoptosis	0.00941046571901774
GO:0022402	cell cycle process	0.00941046571901774
GO:0030262	apoptotic nuclear changes	0.00941046571901774
GO:0006915	apoptosis	0.00941046571901774
GO:0012501	programmed cell death	0.00941046571901774
GO:0001836	release of cytochrome c from mitochondria	0.00941046571901774
GO:0045884	regulation of survival gene product activity	0.00941046571901774
GO:0000186	activation of MAPKK activity	0.00941046571901774
GO:0050974	detection of mechanical stimulus during sensory perception	0.00941046571901774
GO:0008219	cell death	0.00941046571901774
GO:0016265	death	0.00941046571901774
GO:0050982	detection of mechanical stimulus	0.0098288130961369
GO:0006308	DNA catabolic process	0.0098288130961369
GO:0007049	cell cycle	0.0098288130961369
GO:0043279	response to alkaloid	0.0116010135295285
GO:0009612	response to mechanical stimulus	0.0116010135295285
GO:0008637	apoptotic mitochondrial changes	0.0124849380356378
GO:0006919	caspase activation	0.0126723341347702
GO:0043280	positive regulation of caspase activity	0.012846772829689
GO:0022411	cellular component disassembly	0.0130095498608156
GO:0048705	skeletal morphogenesis	0.0131617937762588
GO:0051345	positive regulation of hydrolase activity	0.0133044920556141
GO:0006997	nuclear organization and biogenesis	0.0138618984365038
GO:0007242	intracellular signaling cascade	0.0138618984365038
GO:0010033	response to organic substance	0.0143808690559699
GO:0032147	activation of protein kinase activity	0.0143808690559699
GO:0008629	induction of apoptosis by intracellular signals	0.0143808690559699
GO:0043281	regulation of caspase activity	0.0144687759505001
GO:0048468	cell development	0.0152654088873376
GO:0006469	negative regulation of protein kinase activity	0.0153144448360408
GO:0033673	negative regulation of kinase activity	0.0153144448360408
GO:0005819	spindle	0.0153144448360408
GO:0051348	negative regulation of transferase activity	0.0153144448360408
GO:0016604	nuclear body	0.0153144448360408
GO:0009582	detection of abiotic stimulus	0.0173356064459318
GO:0043086	negative regulation of catalytic activity	0.0180964821540238
GO:0009581	detection of external stimulus	0.0180964821540238
GO:0008632	apoptotic program	0.0180964821540238
GO:0050906	detection of stimulus during sensory perception	0.0198945647774472
GO:0042471	ear morphogenesis	0.0212661807720997
GO:0016485	protein processing	0.0228294942868084
GO:0007005	mitochondrion organization and biogenesis	0.0228294942868084
GO:0051606	detection of stimulus	0.0230661023719913
GO:0043583	ear development	0.0242389304980314
GO:0048869	cellular developmental process	0.0242389304980314
GO:0030154	cell differentiation	0.0242389304980314
GO:0006916	anti-apoptosis	0.0242389304980314
GO:0045860	positive regulation of protein kinase activity	0.0253445269421714
GO:0033674	positive regulation of kinase activity	0.026266444974434
GO:0051347	positive regulation of transferase activity	0.026266444974434
GO:0007605	sensory perception of sound	0.026558655997863
GO:0009314	response to radiation	0.026558655997863
GO:0050954	sensory perception of mechanical stimulus	0.0272582711886683
GO:0051336	regulation of hydrolase activity	0.0301418900256973
GO:0000165	MAPKKK cascade	0.0323920340714532
GO:0007275	multicellular organismal development	0.0330693654384248
GO:0045859	regulation of protein kinase activity	0.0330693654384248
GO:0006917	induction of apoptosis	0.0330693654384248
GO:0012502	induction of programmed cell death	0.0330693654384248
GO:0043549	regulation of kinase activity	0.0333522635888105
GO:0051338	regulation of transferase activity	0.0336270694995324
GO:0043066	negative regulation of apoptosis	0.0365659272351112
GO:0043069	negative regulation of programmed cell death	0.0365659272351112
GO:0043065	positive regulation of apoptosis	0.0388756715682953
GO:0043068	positive regulation of programmed cell death	0.0388756715682953
GO:0009628	response to abiotic stimulus	0.0390584548816205
GO:0008284	positive regulation of cell proliferation	0.0403780821077872
GO:0001501	skeletal development	0.0407618443253016
GO:0007423	sensory organ development	0.0415805314464115
GO:0048598	embryonic morphogenesis	0.0443538016122502
GO:0032502	developmental process	0.04712373003694
GO:0007243	protein kinase cascade	0.04712373003694
GO:0043285	biopolymer catabolic process	0.0490907465633064

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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