MCL coexpression mm9:2669

Phase1 CAGE Peaks

	Short description
Mm9::chr11:41312195..41312229,+	p1@ENSMUST00000119713
Mm9::chr17:56766295..56766316,-	p1@Lonp1
Mm9::chr1:55144669..55144729,-	p1@Hspd1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0006510	ATP-dependent proteolysis	0.00969650481743329
GO:0004176	ATP-dependent peptidase activity	0.00969650481743329
GO:0005739	mitochondrion	0.0379022246412854
GO:0009408	response to heat	0.0379022246412854
GO:0005524	ATP binding	0.0379022246412854
GO:0032559	adenyl ribonucleotide binding	0.0379022246412854
GO:0009266	response to temperature stimulus	0.0379022246412854
GO:0030554	adenyl nucleotide binding	0.0379022246412854
GO:0051082	unfolded protein binding	0.0385158897423126
GO:0032553	ribonucleotide binding	0.0385158897423126
GO:0032555	purine ribonucleotide binding	0.0385158897423126
GO:0017076	purine nucleotide binding	0.0385158897423126
GO:0000166	nucleotide binding	0.0455962095217634

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
abdomen element	2.14e-15	49
abdominal segment element	2.14e-15	49
abdominal segment of trunk	2.14e-15	49
abdomen	2.14e-15	49
epithelial tube	1.58e-12	47
liver	8.69e-12	22
epithelial sac	8.69e-12	22
digestive gland	8.69e-12	22
epithelium of foregut-midgut junction	8.69e-12	22
anatomical boundary	8.69e-12	22
hepatobiliary system	8.69e-12	22
foregut-midgut junction	8.69e-12	22
hepatic diverticulum	8.69e-12	22
liver primordium	8.69e-12	22
septum transversum	8.69e-12	22
liver bud	8.69e-12	22
digestive tract diverticulum	8.76e-12	23
sac	8.76e-12	23
exocrine gland	2.96e-10	25
exocrine system	2.96e-10	25
endocrine gland	2.29e-09	60
subdivision of trunk	2.33e-08	66
gland	3.32e-08	65
endocrine system	5.66e-08	72
gut epithelium	1.14e-07	55
mesenchyme	2.50e-07	61
entire embryonic mesenchyme	2.50e-07	61
trunk mesenchyme	3.63e-07	45
trunk region element	9.20e-07	79

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}