MCL coexpression mm9:2518

Phase1 CAGE Peaks

	Short description
Mm9::chr10:116423707..116423751,+	p1@Best3
Mm9::chr4:58298802..58298847,+	p1@Musk
Mm9::chr4:58298936..58298940,+	p2@Musk

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008582	regulation of synaptic growth at neuromuscular junction	0.0186985855263778
GO:0043271	negative regulation of ion transport	0.0186985855263778
GO:0051124	synaptic growth at neuromuscular junction	0.0186985855263778
GO:0043113	receptor clustering	0.0260380366664266
GO:0043269	regulation of ion transport	0.0260380366664266
GO:0031594	neuromuscular junction	0.0260380366664266
GO:0007172	signal complex assembly	0.0260380366664266
GO:0051051	negative regulation of transport	0.0280355836660596
GO:0007416	synaptogenesis	0.0280355836660596
GO:0007528	neuromuscular junction development	0.0280355836660596
GO:0043112	receptor metabolic process	0.0318542518138791
GO:0043623	cellular protein complex assembly	0.0426693690688228
GO:0050808	synapse organization and biogenesis	0.0426693690688228
GO:0048589	developmental growth	0.0426693690688228
GO:0031404	chloride ion binding	0.0426693690688228
GO:0043168	anion binding	0.0426693690688228
GO:0005254	chloride channel activity	0.0426693690688228
GO:0005253	anion channel activity	0.0426693690688228
GO:0004714	transmembrane receptor protein tyrosine kinase activity	0.0426693690688228
GO:0048741	skeletal muscle fiber development	0.0426693690688228
GO:0048747	muscle fiber development	0.0426693690688228
GO:0019199	transmembrane receptor protein kinase activity	0.0464460139539894

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
surface structure	4.53e-09	22
appendage	4.10e-07	12
paired limb/fin	4.10e-07	12
limb	4.10e-07	12
paired limb/fin bud	4.10e-07	12
limb bud	4.10e-07	12
limb/fin field	4.10e-07	12
limb field	4.10e-07	12

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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